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Search Results to Neil J. Ganem, PhD

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Research Expertise & Professional Interests Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

One or more keywords matched the following items that are connected to Ganem, Neil

Item TypeName
Concept Cell Adhesion
Concept Cell Cycle
Concept Cell Differentiation
Concept Cell Division
Concept Cell Line
Concept Cell Nucleus
Concept Cell Separation
Concept Cell Transformation, Neoplastic
Concept Cells
Concept Cells, Cultured
Concept Epithelial Cells
Concept Eukaryotic Cells
Concept Germ Cells
Concept HeLa Cells
Concept Liver
Concept CHO Cells
Concept Cell Polarity
Concept Cell Cycle Proteins
Concept Myeloid Cells
Concept HCT116 Cells
Concept Cell Line, Tumor
Concept Cell Size
Concept Cell Shape
Concept Cell Proliferation
Concept HEK293 Cells
Concept MCF-7 Cells
Academic Article The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.
Academic Article Efficient mitosis in human cells lacking poleward microtubule flux.
Academic Article Functional roles of poleward microtubule flux during mitosis.
Academic Article Tetraploidy, aneuploidy and cancer.
Academic Article The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.
Academic Article Limiting the proliferation of polyploid cells.
Academic Article Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.
Academic Article A mechanism linking extra centrosomes to chromosomal instability.
Academic Article Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression.
Academic Article DNA breaks and chromosome pulverization from errors in mitosis.
Academic Article Linking abnormal mitosis to the acquisition of DNA damage.
Academic Article Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.
Academic Article Cytokinesis failure triggers hippo tumor suppressor pathway activation.
Academic Article Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes.
Academic Article Nuclear envelope rupture drives genome instability in cancer.
Academic Article The interplay between centrosomes and the Hippo tumor suppressor pathway.
Academic Article Generation and Purification of Tetraploid Cells.
Award or Honor Receipt First Place
Academic Article Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors.
Academic Article STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines.
Academic Article A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation.
Academic Article Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel.
Academic Article Identification of the kinase STK25 as an upstream activator of LATS signaling.
Academic Article LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.
Grant Defining Novel Pathways that Arrest Genetically Unstable Tetraploid Cells

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