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Search Results to Suryaram Gummuluru, PhD

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Research Expertise & Professional Interests Our research is broadly focused on the role of dendritic cells (DCs) in the initiation and propagation of HIV-1 replication. Since dendritic cells are believed to be the first immune competent cells to encounter virus in the genital mucosa, a thorough understanding of the HIV-DC interactions is of paramount importance. DCs can capture virus particles independently of CD4 and co-receptor complexes, and retain them in an infectious state for an extended period of time. These virus-bearing DCs may then facilitate a more efficient spread of virus to replication-permissive CD4+ T cells. Our recent work has identified a novel glycosphingolipid dependent mechanism of virus attachment to DCs. The fate of the virus particle post-attachment in DCs remains unclear. Virion trafficking within the DC bypasses conventional endocytic organelles, i.e., endosomes and lysosomes. Virus localization within this novel vesicular compartment not only has the potential to protect the invading HIV from being degraded, but also creates a latent reservoir of virus, which could present a major challenge for eradication by antiretroviral therapy. Furthermore, the mechanism of subsequent return of infectious virus particles to the cell surface and the method of subsequent transmission to T cells remains unclear. Current studies utilizing biochemical and microscopic approaches are underway to monitor HIV-1 trafficking and localization in the DC and its subsequent transfer to T cells.
Self-Described Keywords dendritic cells

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Concept Dendritic Cells
Academic Article Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnover.
Academic Article Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol-dependent pathway.
Academic Article Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection.
Academic Article Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway.
Academic Article Glycosphingolipid composition of human immunodeficiency virus type 1 (HIV-1) particles is a crucial determinant for dendritic cell-mediated HIV-1 trans-infection.
Academic Article PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection.
Academic Article Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection.
Academic Article Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infection.
Academic Article HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells.
Academic Article Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169.
Academic Article Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells.
Academic Article Virus particle release from glycosphingolipid-enriched microdomains is essential for dendritic cell-mediated capture and transfer of HIV-1 and henipavirus.
Academic Article A mechanistic overview of dendritic cell-mediated HIV-1 trans infection: the story so far.
Academic Article Dressing up Nanoparticles: A Membrane Wrap to Induce Formation of the Virological Synapse.
Academic Article CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination.
Academic Article CD169-mediated trafficking of HIV to plasma membrane invaginations in dendritic cells attenuates efficacy of anti-gp120 broadly neutralizing antibodies.
Academic Article Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated.
Academic Article Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation.
Academic Article Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells.
Academic Article Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon.
Academic Article HIV-1 replicates and persists in vaginal epithelial dendritic cells.
Grant CD1a vaginal dendritic cells and HIV-1 acquisition in the female genital tract

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