Search Results to Suryaram Gummuluru, PhD

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Research Expertise & Professional Interests Our research is broadly focused on the role of dendritic cells (DCs) in the initiation and propagation of HIV-1 replication. Since dendritic cells are believed to be the first immune competent cells to encounter virus in the genital mucosa, a thorough understanding of the HIV-DC interactions is of paramount importance. DCs can capture virus particles independently of CD4 and co-receptor complexes, and retain them in an infectious state for an extended period of time. These virus-bearing DCs may then facilitate a more efficient spread of virus to replication-permissive CD4+ T cells. Our recent work has identified a novel glycosphingolipid dependent mechanism of virus attachment to DCs. The fate of the virus particle post-attachment in DCs remains unclear. Virion trafficking within the DC bypasses conventional endocytic organelles, i.e., endosomes and lysosomes. Virus localization within this novel vesicular compartment not only has the potential to protect the invading HIV from being degraded, but also creates a latent reservoir of virus, which could present a major challenge for eradication by antiretroviral therapy. Furthermore, the mechanism of subsequent return of infectious virus particles to the cell surface and the method of subsequent transmission to T cells remains unclear. Current studies utilizing biochemical and microscopic approaches are underway to monitor HIV-1 trafficking and localization in the DC and its subsequent transfer to T cells.
Self-Described Keywords HIV pathogenesis

One or more keywords matched the following items that are connected to Gummuluru, Suryaram

Item TypeName
Concept HIV Seropositivity
Concept HIV Antibodies
Concept HIV-1
Concept HIV-2
Concept HIV Infections
Concept HIV Envelope Protein gp120
Concept HIV Long Terminal Repeat
Concept Anti-HIV Agents
Concept Human Immunodeficiency Virus Proteins
Concept gag Gene Products, Human Immunodeficiency Virus
Concept nef Gene Products, Human Immunodeficiency Virus
Concept vif Gene Products, Human Immunodeficiency Virus
Concept vpr Gene Products, Human Immunodeficiency Virus
Academic Article Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA.
Academic Article Expression of pro- and anti-apoptosis gene products in brains from paediatric patients with HIV-1 encephalitis.
Academic Article Cell cycle- and Vpr-mediated regulation of human immunodeficiency virus type 1 expression in primary and transformed T-cell lines.
Academic Article An in vitro rapid-turnover assay for human immunodeficiency virus type 1 replication selects for cell-to-cell spread of virus.
Academic Article Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnover.
Academic Article Advances in HIV molecular biology.
Academic Article Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol-dependent pathway.
Academic Article Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection.
Academic Article Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway.
Academic Article Glycosphingolipid composition of human immunodeficiency virus type 1 (HIV-1) particles is a crucial determinant for dendritic cell-mediated HIV-1 trans-infection.
Academic Article PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection.
Academic Article Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection.
Academic Article Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infection.
Academic Article HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells.
Academic Article Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization.
Academic Article Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169.
Academic Article Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells.
Academic Article Virus particle release from glycosphingolipid-enriched microdomains is essential for dendritic cell-mediated capture and transfer of HIV-1 and henipavirus.
Academic Article A mechanistic overview of dendritic cell-mediated HIV-1 trans infection: the story so far.
Academic Article Dressing up Nanoparticles: A Membrane Wrap to Induce Formation of the Virological Synapse.
Academic Article CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination.
Academic Article CD169-mediated trafficking of HIV to plasma membrane invaginations in dendritic cells attenuates efficacy of anti-gp120 broadly neutralizing antibodies.
Academic Article Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated.
Academic Article Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells.
Academic Article Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon.
Academic Article Membrane Fluidity Sensing on the Single Virus Particle Level with Plasmonic Nanoparticle Transducers.
Academic Article HIV-1 replicates and persists in vaginal epithelial dendritic cells.
Academic Article HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction.
Academic Article TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins.
Academic Article Strength of T cell signaling regulates HIV-1 replication and establishment of latency.
Academic Article Illuminating the Role of Vpr in HIV Infection of Myeloid Cells.
Academic Article HIV-1 Persistence and Chronic Induction of Innate Immune Responses in Macrophages.
Academic Article Stiffness of HIV-1 Mimicking Polymer Nanoparticles Modulates Ganglioside-Mediated Cellular Uptake and Trafficking.
Grant Mechanism of Cell-Associated HIV-1 Transmission
Grant Identification of Signals Required for the Establishment of HIV infection and Latency
Grant Mechanism of Cell-Associated HIV-1 Transmission
Grant Engineering a 3D human neurovascular unit for investigating and countering neuroinflammatory mechanisms of HIV
Grant Persistent HIV expression induced type 1 IFN responses and inflammaging
Grant A novel microfluidic system to investigate mechanism of HIV-induced disruption of BBB function
Grant Synergistic Mechanisms of chronic Innate Immune Activation in Microglia by opiates and HIV Infection
Grant Signals that establish and maintain HIV latency
Grant Elucidating Non-Virus Encoded HIV Capture Through Artificial Virus Nanoparticles
Grant CD1a vaginal dendritic cells and HIV-1 acquisition in the female genital tract

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  • pathogenesis