Search Results to Suryaram Gummuluru, PhD

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Research Expertise & Professional Interests Our research is broadly focused on the role of dendritic cells (DCs) in the initiation and propagation of HIV-1 replication. Since dendritic cells are believed to be the first immune competent cells to encounter virus in the genital mucosa, a thorough understanding of the HIV-DC interactions is of paramount importance. DCs can capture virus particles independently of CD4 and co-receptor complexes, and retain them in an infectious state for an extended period of time. These virus-bearing DCs may then facilitate a more efficient spread of virus to replication-permissive CD4+ T cells. Our recent work has identified a novel glycosphingolipid dependent mechanism of virus attachment to DCs. The fate of the virus particle post-attachment in DCs remains unclear. Virion trafficking within the DC bypasses conventional endocytic organelles, i.e., endosomes and lysosomes. Virus localization within this novel vesicular compartment not only has the potential to protect the invading HIV from being degraded, but also creates a latent reservoir of virus, which could present a major challenge for eradication by antiretroviral therapy. Furthermore, the mechanism of subsequent return of infectious virus particles to the cell surface and the method of subsequent transmission to T cells remains unclear. Current studies utilizing biochemical and microscopic approaches are underway to monitor HIV-1 trafficking and localization in the DC and its subsequent transfer to T cells.
Self-Described Keywords virus attachment, trafficking, and cell-mediated virus transfer

One or more keywords matched the following items that are connected to Gummuluru, Suryaram

Item TypeName
Concept Infectious Anemia Virus, Equine
Concept Hepatitis B virus
Concept Leukemia Virus, Murine
Concept Virus Activation
Concept Virus Cultivation
Concept Virus Replication
Concept Simian Immunodeficiency Virus
Concept Herpesvirus 6, Human
Concept Virus Integration
Concept Virus Latency
Concept Virus Assembly
Concept Virus Inactivation
Concept Virus Attachment
Concept Virus Internalization
Concept Human Immunodeficiency Virus Proteins
Concept gag Gene Products, Human Immunodeficiency Virus
Concept nef Gene Products, Human Immunodeficiency Virus
Concept vif Gene Products, Human Immunodeficiency Virus
Concept vpr Gene Products, Human Immunodeficiency Virus
Concept Virus Release
Academic Article SIVsmmPBj14 induces expression of a mucosal integrin on macaque lymphocytes.
Academic Article Direct sequence analysis of human herpesvirus 6 (HHV-6) sequences from infants and comparison of HHV-6 sequences from mother/infant pairs.
Academic Article Apoptosis correlates with immune activation in intestinal lymphoid tissue from macaques acutely infected by a highly enteropathic simian immunodeficiency virus, SIVsmmPBj14.
Academic Article Costimulatory pathways in lymphocyte proliferation induced by the simian immunodeficiency virus SIVsmmPBj14.
Academic Article Cell cycle- and Vpr-mediated regulation of human immunodeficiency virus type 1 expression in primary and transformed T-cell lines.
Academic Article An in vitro rapid-turnover assay for human immunodeficiency virus type 1 replication selects for cell-to-cell spread of virus.
Academic Article Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnover.
Academic Article Advances in HIV molecular biology.
Academic Article Binding of human immunodeficiency virus type 1 to immature dendritic cells can occur independently of DC-SIGN and mannose binding C-type lectin receptors via a cholesterol-dependent pathway.
Academic Article Deamination-independent inhibition of hepatitis B virus reverse transcription by APOBEC3G.
Academic Article Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway.
Academic Article Glycosphingolipid composition of human immunodeficiency virus type 1 (HIV-1) particles is a crucial determinant for dendritic cell-mediated HIV-1 trans-infection.
Academic Article Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization.
Academic Article Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.
Academic Article Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells.
Academic Article Virus particle release from glycosphingolipid-enriched microdomains is essential for dendritic cell-mediated capture and transfer of HIV-1 and henipavirus.
Academic Article CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination.
Academic Article CD169-mediated trafficking of HIV to plasma membrane invaginations in dendritic cells attenuates efficacy of anti-gp120 broadly neutralizing antibodies.
Academic Article Quantifying lipid contents in enveloped virus particles with plasmonic nanoparticles.
Academic Article Functional Interplay Between Murine Leukemia Virus Glycogag, Serinc5, and Surface Glycoprotein Governs Virus Entry, with Opposite Effects on Gammaretroviral and Ebolavirus Glycoproteins.
Academic Article Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated.
Academic Article Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells.
Academic Article Spontaneous Mutation at Amino Acid 544 of the Ebola Virus Glycoprotein Potentiates Virus Entry and Selection in Tissue Culture.
Academic Article Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon.
Academic Article Plasmonic Enhancement of Selective Photonic Virus Inactivation.
Academic Article Membrane Fluidity Sensing on the Single Virus Particle Level with Plasmonic Nanoparticle Transducers.
Academic Article HIV-1 replicates and persists in vaginal epithelial dendritic cells.
Academic Article Membrane-wrapped nanoparticles probe divergent roles of GM3 and phosphatidylserine in lipid-mediated viral entry pathways.
Academic Article TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins.
Academic Article Strength of T cell signaling regulates HIV-1 replication and establishment of latency.
Grant Elucidating Non-Virus Encoded HIV Capture Through Artificial Virus Nanoparticles

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