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Search Results to Jeffrey L. Browning, PhD

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Research Expertise & Professional Interests My interests focus on understanding how the immune system interacts with stromal elements to form the specialized structures that orchestrate immunological encounters in lymphoid organs. On a different plane, the barriers to effective quantitation of disease are formidable in some autoimmune diseases especially those with considerable unmet need such as lupus and scleroderma. I am interested in bringing new views onto the human immune system to improve clinical studies. Mesenchymal cell differentiation pathways are intimately interwoven with pathological processes e.g. compromised vascular integrity, aberrant tissue remodeling and fibrosis and tumor-stromal interactions. In lymphoid organs, the lymphotoxin pathway, a TNF family member, is one mechanism by which both innate and adaptive lymphoid cells communicate with their stromal microenvironments. The maintenance of a differentiated follicular dendritic cell network to scaffold the B cell follicle is a well-studied example of this communication. More recently, it is clear that another network, the fibroblastoid reticular cell network, is a differentiated form of mural cells, e.g. pericytes or vascular smooth muscle cells. The precise role of the lymphotoxin pathway in controlling this structure is an area of investigation. As lymph nodes can undergo massive expansion in response to danger following by involution, they form an intriguing model of physiological tissue remodeling. Using this foundation, we have been studying the stromal underpinnings of the perivascular adventitial compartment. this compartment is considered crucial to harbor stem cells, tissue resident leucocytes and sense and initiate repair/remodelling efforts after injury. Human skin has provided an excellent tool to observe these stromal perivascular networks.

One or more keywords matched the following items that are connected to Browning, Jeffrey

Item TypeName
Concept Drug Interactions
Concept Interferon Type I
Concept Interferon-gamma
Concept Interferons
Concept Interleukin-1
Concept Interleukin-2
Concept Interleukins
Concept Lymphoid Tissue
Concept Nerve Tissue Proteins
Concept Tissue Distribution
Concept Interleukin-4
Concept Interleukin-6
Concept Interleukin-8
Concept Interferon-alpha
Concept Receptors, Interleukin-1
Concept Intercellular Adhesion Molecule-1
Concept Interleukin-17
Concept RNA, Small Interfering
Concept Transmembrane Activator and CAML Interactor Protein
Concept Interleukin-1beta
Concept Interleukin 1 Receptor Antagonist Protein
Academic Article Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines.
Academic Article Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs.
Academic Article Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice.
Academic Article The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues.
Academic Article Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development.
Academic Article Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues.
Academic Article Functional effects of TNF and lymphotoxin alpha1beta2 on FDC-like cells.
Academic Article A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth.
Academic Article Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis.
Academic Article BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.
Academic Article Lymphotoxin/light, lymphoid microenvironments and autoimmune disease.
Academic Article TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration.
Academic Article Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actions.
Academic Article Human extracellular recombinant phospholipase A2 induces an inflammatory response in rabbit joints.
Academic Article Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease.
Academic Article TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor.
Academic Article LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR.
Academic Article Lymphotoxin and the amazing technicolor circus of intestinal homeostasis.
Academic Article Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells.
Academic Article Purification and partial sequence analysis of a 37-kDa protein that inhibits phospholipase A2 activity from rat peritoneal exudates.
Academic Article Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes.
Academic Article Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells.
Academic Article Disulfide scrambling of interleukin-2: HPLC resolution of the three possible isomers.
Academic Article Human nonpancreatic secreted phospholipase A2: interfacial parameters, substrate specificities, and competitive inhibitors.
Academic Article Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia.
Academic Article Interferons and rheumatoid arthritis: insight into interferon biology?
Academic Article Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
Academic Article Role of the Lymphotoxin/LIGHT System in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues.
Academic Article Lymphotoxin-LIGHT pathway regulates the interferon signature in rheumatoid arthritis.
Academic Article The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity.
Academic Article Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Academic Article Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90.
Grant Biomarker based prediction models for response to treatment in systemic sclerosis related interstitial lung disease

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