Search Results to Jeffrey L. Browning, PhD

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Research Expertise & Professional Interests My interests focus on understanding how the immune system interacts with stromal elements to form the specialized structures that orchestrate immunological encounters in lymphoid organs. On a different plane, the barriers to effective quantitation of disease are formidable in some autoimmune diseases especially those with considerable unmet need such as lupus and scleroderma. I am interested in bringing new views onto the human immune system to improve clinical studies. Mesenchymal cell differentiation pathways are intimately interwoven with pathological processes e.g. compromised vascular integrity, aberrant tissue remodeling and fibrosis and tumor-stromal interactions. In lymphoid organs, the lymphotoxin pathway, a TNF family member, is one mechanism by which both innate and adaptive lymphoid cells communicate with their stromal microenvironments. The maintenance of a differentiated follicular dendritic cell network to scaffold the B cell follicle is a well-studied example of this communication. More recently, it is clear that another network, the fibroblastoid reticular cell network, is a differentiated form of mural cells, e.g. pericytes or vascular smooth muscle cells. The precise role of the lymphotoxin pathway in controlling this structure is an area of investigation. As lymph nodes can undergo massive expansion in response to danger following by involution, they form an intriguing model of physiological tissue remodeling. Using this foundation, we have been studying the stromal underpinnings of the perivascular adventitial compartment. this compartment is considered crucial to harbor stem cells, tissue resident leucocytes and sense and initiate repair/remodelling efforts after injury. Human skin has provided an excellent tool to observe these stromal perivascular networks.

One or more keywords matched the following items that are connected to Browning, Jeffrey

Item TypeName
Concept Dendritic Cells
Concept Dendritic Cells, Follicular
Academic Article Turning off follicular dendritic cells.
Academic Article BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Academic Article The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues.
Academic Article The sequential role of lymphotoxin and B cells in the development of splenic follicles.
Academic Article Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development.
Academic Article Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues.
Academic Article A chemokine-driven positive feedback loop organizes lymphoid follicles.
Academic Article Functional effects of TNF and lymphotoxin alpha1beta2 on FDC-like cells.
Academic Article Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice.
Academic Article Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway.
Academic Article Lymphotoxin/light, lymphoid microenvironments and autoimmune disease.
Academic Article Workshop summary: control of lymphocyte function and repertoire by the TNF superfamily.
Academic Article Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells.
Academic Article Follicular dendritic cells emerge from ubiquitous perivascular precursors.
Academic Article The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity.
Academic Article Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis.
Grant Modulation of DCLK1 and Related Pathways as Targets in Lupus Nephritis

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