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Research Expertise & Professional Interests Dr. Manish Sagar is an Associate Professor of Medicine at the Boston University School of Medicine. My laboratory is primarily interested in human immunodeficiency virus type 1 (HIV-1) mucosal HIV-1 transmission and antibodies. One of our focus is to understand the biological mechanisms for the selection observed during HIV-1 transmission. Even though chronically infected subjects harbor extensive variants during transmission, only a limited number of viruses are acquired by newly infected partners. Genotypic examination of viruses present in the newly infected subject compared to those circulating in the transmitting partner suggests that the observed genetic bottleneck during transmission is not due to random chance. Laboratory studies explore the hypothesis that during transmission there is selection of specific variants with properties that confer fitness for transmission. Another focus in the lab is to decipher correlate of immune protection. Even though infants are exposed to infected breast milk, only a small proportion (around 30%) acquire HIV-1 from their infected mother in the absence of antiretroviral protection. We hypothesize that maternally acquired antibodies present in the infant prevent HIV-1 acquisition either through neutralization or antibody dependent cellular cytotoxicity against the variants circulating in the maternal breast milk. Defining the immune correlate of protection will have important implications for HIV-1 vaccine design. Our work focuses on understanding HIV-1 envelope and host antibody evolution and impact on disease pathogenesis. Dr. Sagar has served on numerous committees including NIH study sections and Doris Duke Charitable Foundation Early Career Development Award Review Committee. He is an active member of the Infectious Diseases Society of America (IDSA).

One or more keywords matched the following items that are connected to Sagar, Manish

Item TypeName
Concept HIV
Concept HIV Seropositivity
Concept HIV Antibodies
Concept HIV Antigens
Concept HIV-1
Concept HIV Infections
Concept HIV Envelope Protein gp120
Concept Receptors, HIV
Concept HIV Core Protein p24
Concept HIV Protease Inhibitors
Concept Anti-HIV Agents
Concept HIV Fusion Inhibitors
Concept env Gene Products, Human Immunodeficiency Virus
Concept gag Gene Products, Human Immunodeficiency Virus
Concept HIV Reverse Transcriptase
Academic Article Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression.
Academic Article Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population.
Academic Article Human immunodeficiency virus type 1 (HIV-1) diversity at time of infection is not restricted to certain risk groups or specific HIV-1 subtypes.
Academic Article Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels.
Academic Article Effect of contraceptive methods on natural history of HIV: studies from the Mombasa cohort.
Academic Article No evidence for rapid subtype C spread within an epidemic in which multiple subtypes and intersubtype recombinants circulate.
Academic Article Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection.
Academic Article Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity.
Academic Article In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject.
Academic Article Selection of HIV variants with signature genotypic characteristics during heterosexual transmission.
Academic Article In vivo fitness cost of the M184V mutation in multidrug-resistant human immunodeficiency virus type 1 in the absence of lamivudine.
Academic Article Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection.
Academic Article HIV-1 transmission biology: selection and characteristics of infecting viruses.
Academic Article Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate.
Academic Article Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C.
Academic Article Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infection.
Academic Article Sensitivity changes over the course of infection increases the likelihood of resistance against fusion but not CCR5 receptor blockers.
Academic Article Previously transmitted HIV-1 strains are preferentially selected during subsequent sexual transmissions.
Academic Article Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation.
Academic Article Clinical implications of new findings in HIV basic research.
Academic Article Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence trial.
Academic Article Early infection HIV-1 envelope V1-V2 genotypes do not enhance binding or replication in cells expressing high levels of a4ß7 integrin.
Academic Article HIV-1 envelope replication and a4ß7 utilization among newly infected subjects and their corresponding heterosexual partners.
Academic Article Origin of the transmitted virus in HIV infection: infected cells versus cell-free virus.
Academic Article Characterization of HIV-1 envelopes in acutely and chronically infected injection drug users.
Academic Article Comparison of the metabolic effects of ritonavir-boosted darunavir or atazanavir versus raltegravir, and the impact of ritonavir plasma exposure: ACTG 5257.
Academic Article Single genome amplification and standard bulk PCR yield HIV-1 envelope products with similar genotypic and phenotypic characteristics.
Academic Article Humoral Immune Pressure Selects for HIV-1 CXC-chemokine Receptor 4-using Variants.
Academic Article Antibodies and Acidic Environment Do Not Enhance HIV-1 Transcytosis.
Award or Honor Receipt Chair Host and Viral Factors in HIV-1 Transmission
Academic Article Maternal but Not Infant Anti-HIV-1 Neutralizing Antibody Response Associates with Enhanced Transmission and Infant Morbidity.
Academic Article HIV-1 replicates and persists in vaginal epithelial dendritic cells.
Academic Article Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans.
Academic Article Condylomata Acuminata (Anogenital Warts) Contain Accumulations of HIV-1 Target Cells That May Provide Portals for HIV Transmission.
Academic Article HIV-1 Coreceptor Usage and Variable Loop Contact Impact V3 Loop Broadly Neutralizing Antibody Susceptibility.
Academic Article Neutralization and beyond: Antibodies and HIV-1 acquisition.
Grant HIV-1 mucosal transmission and persistence
Grant Identification and characterization of individuals with elite anti-HIV-1 ADCC
Grant CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
Grant Neutralizing and Non-neutralizing Antibodies Protection from Breast Milk HIV-1
Grant CD1a Vaginal Dendritic Cells and HIV-1 Acquisition in the Female Genital Tract
Academic Article A new cell line for assessing HIV-1 antibody dependent cellular cytotoxicity against a broad range of variants.
Academic Article HIV-1 transcription but not intact provirus levels are associated with systemic inflammation.

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