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Search Results to David J. Waxman, PhD

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Self-Described Keywords genomic and epigenetic mechanisms controlling liver gene expression

One or more keywords matched the following items that are connected to Waxman, David

Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Base Sequence
Concept Gene Conversion
Concept Gene Expression Regulation
Concept Genes
Concept Genes, Dominant
Concept Genes, Regulator
Concept Multigene Family
Concept Lac Operon
Concept Molecular Sequence Data
Concept Nucleic Acid Conformation
Concept Oncogenes
Concept Pseudogenes
Concept Sequence Homology, Nucleic Acid
Concept Molecular Structure
Concept Down-Regulation
Concept Gene Expression
Concept Genome, Human
Concept Gene Expression Regulation, Enzymologic
Concept Gene Expression Regulation, Neoplastic
Concept Genome
Concept Gene Deletion
Concept Genes, Reporter
Concept Gene Transfer Techniques
Concept Gene Expression Regulation, Developmental
Concept src Homology Domains
Concept Transgenes
Concept Catalytic Domain
Concept Gene Silencing
Concept Gene Expression Profiling
Concept Gene Order
Concept Regulatory Elements, Transcriptional
Concept Gene Regulatory Networks
Concept Gene Knockdown Techniques
Concept Gene Knockout Techniques
Concept Transcriptome
Concept Genes, Modifier
Academic Article Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.
Academic Article Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5.
Academic Article Intrinsic sex differences in the early growth hormone responsiveness of sex-specific genes in mouse liver.
Academic Article Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
Academic Article Changes in mouse uterine transcriptome in estrus and proestrus.
Academic Article Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis.
Academic Article STAT5 signaling in sexually dimorphic gene expression and growth patterns.
Academic Article The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.
Academic Article Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression.
Academic Article Thyroid regulation of NADPH:cytochrome P450 oxidoreductase: identification of a thyroid-responsive element in the 5'-flank of the oxidoreductase gene.
Academic Article Sexual dimorphism of hepatic gene expression: novel biological role of KRAB zinc finger repressors revealed.
Academic Article Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone.
Academic Article A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition.
Academic Article Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver.
Academic Article Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.
Academic Article Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).
Academic Article Role of hepatocyte nuclear factors in growth hormone-regulated, sexually dimorphic expression of liver cytochromes P450.
Academic Article STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression.
Academic Article Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis.
Academic Article Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver.
Academic Article Harnessing apoptosis for improved anticancer gene therapy.
Academic Article Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy.
Academic Article Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus.
Academic Article Sex-Biased lncRNAs Inversely Correlate With Sex-Opposite Gene Coexpression Networks in Diversity Outbred Mouse Liver.
Academic Article Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female specific expression of CYP2C12 in adult rat liver.
Academic Article Plasma growth hormone pulse activation of hepatic JAK-STAT5 signaling: developmental regulation and role in male-specific liver gene expression.
Academic Article Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model.
Academic Article Post-transcriptional regulation of hepatic NADPH-cytochrome P450 reductase by thyroid hormone: independent effects on poly(A) tail length and mRNA stability.
Academic Article Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.
Academic Article Progress and prospects: gene therapy clinical trials (part 2).
Academic Article Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment.
Academic Article CpG-1826 immunotherapy potentiates chemotherapeutic and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model.
Academic Article Regulation and ligand-binding specificities of two sex-specific bile acid-binding proteins of rat liver cytosol.
Academic Article Growth hormone pulse-activated STAT5 signalling: a unique regulatory mechanism governing sexual dimorphism of liver gene expression.
Academic Article Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression.
Academic Article Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model.
Academic Article Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.
Academic Article Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib.
Academic Article Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells.
Academic Article Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators.
Academic Article Hormonal regulation of levels of the messenger RNA encoding hepatic P450 2c (IIC11), a constitutive male-specific form of cytochrome P450.
Academic Article Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy.
Academic Article Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors.
Academic Article STAT5b is required for GH-induced liver IGF-I gene expression.
Academic Article Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease.
Academic Article Sex-specific early growth hormone response genes in rat liver.
Academic Article Interactions of methoxyacetic acid with androgen receptor.
Academic Article Impact of CUX2 on the female mouse liver transcriptome: activation of female-biased genes and repression of male-biased genes.
Academic Article Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation.
Academic Article Rat liver cytochrome P450 2B3: structure of the CYP2B3 gene and immunological identification of a constitutive P450 2B3-like protein in rat liver.
Academic Article Cytochrome P450 2B1 mediates complement-dependent sublytic injury in a model of membranous nephropathy.
Academic Article Cytochrome P450-based cancer gene therapy: recent advances and future prospects.
Academic Article Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma.
Academic Article STAT5b down-regulates peroxisome proliferator-activated receptor alpha transcription by inhibition of ligand-independent activation function region-1 trans-activation domain.
Academic Article The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation.
Academic Article Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy.
Academic Article Dual E1A oncolytic adenovirus: targeting tumor heterogeneity with two independent cancer-specific promoter elements, DF3/MUC1 and hTERT.
Academic Article Widespread Dysregulation of Long Noncoding Genes Associated With Fatty Acid Metabolism, Cell Division, and Immune Response Gene Networks in Xenobiotic-exposed Rat Liver.
Academic Article Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
Academic Article Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer.
Academic Article Regulation of liver-specific steroid metabolizing cytochromes P450: cholesterol 7a-hydroxylase, bile acid 6ß-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases.
Academic Article Selection of cytochrome p450 genes for use in prodrug activation-based cancer gene therapy.
Academic Article Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.
Academic Article 7 in vitro methods for evaluation of p450-based anticancer gene therapy.
Academic Article 8 tumor models for evaluation of p450 gene therapy in vivo.
Academic Article Human telomerase reverse transcriptase promoter-driven oncolytic adenovirus with E1B-19 kDa and E1B-55 kDa gene deletions.
Academic Article Pregnane X receptor-mediated transcription.
Academic Article Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib.
Academic Article Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer.
Academic Article Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy.
Academic Article Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation.
Academic Article Growth hormone regulation of sex-dependent liver gene expression.
Academic Article Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy.
Academic Article Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.
Academic Article Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood.
Academic Article Complex modulation of androgen responsive gene expression by methoxyacetic acid.
Academic Article Dynamic in vivo binding of STAT5 to growth hormone-regulated genes in intact rat liver. Sex-specific binding at low- but not high-affinity STAT5 sites.
Academic Article Hormonal regulation of rat liver microsomal enzymes. Role of gonadal steroids in programming, maintenance, and suppression of delta 4-steroid 5 alpha-reductase, flavin-containing monooxygenase, and sex-specific cytochromes P-450.
Academic Article Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.
Academic Article Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts.
Academic Article Environmental phthalate monoesters activate pregnane X receptor-mediated transcription.
Academic Article Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b.
Academic Article Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression.
Academic Article Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes.
Academic Article Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver.
Academic Article Cytochrome p450-based gene therapies for cancer.
Academic Article Growth hormone, but not prolactin, maintains, low-level activation of STAT5a and STAT5b in female rat liver.
Academic Article Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver.
Academic Article Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma.
Academic Article Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver.
Academic Article Activation of Male Liver Chromatin Accessibility and STAT5-Dependent Gene Transcription by Plasma Growth Hormone Pulses.
Academic Article Pituitary regulation of the male-specific steroid 6 beta-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational leve;.
Academic Article Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer.
Academic Article Impact of methoxyacetic acid on mouse Leydig cell gene expression.
Academic Article Adenoviral vectors for prodrug activation-based gene therapy for cancer.
Academic Article Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice.
Academic Article P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.
Academic Article Hepatic Long Intergenic Noncoding RNAs: High Promoter Conservation and Dynamic, Sex-Dependent Transcriptional Regulation by Growth Hormone.
Academic Article Gene-specific oligonucleotide probes for alpha, mu, pi, and microsomal rat glutathione S-transferases: analysis of liver transferase expression and its modulation by hepatic enzyme inducers and platinum anticancer drugs.
Academic Article Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization.
Academic Article Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression.
Academic Article Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2.
Academic Article Feminization of rat hepatic P-450 expression by cisplatin. Evidence for perturbations in the hormonal regulation of steroid-metabolizing enzymes.
Academic Article Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription.
Academic Article Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice.
Academic Article Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer.
Academic Article Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.
Academic Article Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells.
Academic Article Pulsatility of growth hormone (GH) signalling in liver cells: role of the JAK-STAT5b pathway in GH action.
Academic Article MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets.
Academic Article Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth hormone.
Academic Article Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profile.
Academic Article Growth hormone-dependent and -independent sexually dimorphic regulation of phenobarbital-induced hepatic cytochromes P450 2B1 and 2B2.
Academic Article Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450.
Academic Article Sex differences in the expression of hepatic drug metabolizing enzymes.
Academic Article Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver.
Academic Article Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+.
Academic Article Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver.
Academic Article Hepatic P-450 cholesterol 7 alpha-hydroxylase. Regulation in vivo at the protein and mRNA level in response to mevalonate, diurnal rhythm, and bile acid feedback.
Academic Article Phenobarbital induction of cytochrome P-450 gene expression.
Academic Article Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression.
Academic Article Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.
Academic Article Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha.
Academic Article Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene.
Academic Article Functional Roles of Sex-Biased, Growth Hormone-Regulated MicroRNAs miR-1948 and miR-802 in Young Adult Mouse Liver.
Academic Article Thyroid hormone stimulation of NADPH P450 reductase expression in liver and extrahepatic tissues. Regulation by multiple mechanisms.
Academic Article Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event.
Academic Article Use of reverse transcription-polymerase chain reaction to evaluate in vivo cytokine gene expression in rats fed ethanol for long periods.
Academic Article Sex-specific, growth hormone-regulated transcription of the cytochrome P450 2C11 and 2C12 genes.
Academic Article Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid omega-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone.
Academic Article Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression.
Academic Article P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.
Academic Article Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35.
Academic Article Evaluation of thyroid hormone effects on liver P450 reductase translation.
Academic Article Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer.
Academic Article Hepatic P450 expression in hypothyroid rats: differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11), and RLM2 (IIA2) to thyroid hormone.
Academic Article trans-activation of PPARalpha and induction of PPARalpha target genes by perfluorooctane-based chemicals.
Academic Article Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase.
Academic Article Impact of CAR Agonist Ligand TCPOBOP on Mouse Liver Chromatin Accessibility.
Academic Article Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver.
Academic Article Signalling elements in the ultradian rhythm of circulating growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450.
Academic Article Phenotypic differences in expression of cytochrome P-450g but not its mRNA in outbred male Sprague-Dawley rats.
Academic Article Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate.
Academic Article Phosphorylation of carcinogen metabolizing enzymes: regulation of the phosphorylation status of the major phenobarbital inducible cytochromes P-450 in hepatocytes.
Academic Article Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways.
Grant Growth Hormone Regulation of Sex Differences in Liver Metabolism
Grant Regulation of Sex Differences in Liver Metabolism
Grant Regulation of Sex Differences in Liver Metabolism
Grant Regulation of Sex Differences in Liver Metabolism
Academic Article Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2.
Academic Article Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver.

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