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Search Results to David J. Waxman, PhD

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Research Expertise & Professional Interests David J. Waxman, PhD is a Biologist with extensive experience in the fields of biochemistry, molecular biology, and enzymology. Over the past 35 years, his lab has made seminal contributions to the research of cancer pharmacology and therapeutics, and steroid-metabolizing enzymes. Dr. Waxman has spoken at over 130 conferences and has held appointments at a variety of universities including Harvard Medical School, MIT, and the Weizmann Institute.
Self-Described Keywords genomic and epigenetic mechanisms controlling liver gene expression
Self-Described Keywords role of angiogenesis and innate immune system in cancer therapy and pharmacology

One or more keywords matched the following items that are connected to Waxman, David

Item TypeName
Concept Brain Neoplasms
Concept Breast Neoplasms
Concept Colonic Neoplasms
Concept Combined Modality Therapy
Concept Drug Therapy, Combination
Concept Liver Neoplasms
Concept Liver Neoplasms, Experimental
Concept Lung Neoplasms
Concept Mammary Neoplasms, Experimental
Concept Meningeal Neoplasms
Concept Neoplasms
Concept Neoplasms, Experimental
Concept Neoplasms, Hormone-Dependent
Concept Prostatic Neoplasms
Concept Skin Neoplasms
Concept Testicular Neoplasms
Concept Genetic Therapy
Concept Endometrial Neoplasms
Concept Treatment Outcome
Academic Article Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
Academic Article Conditionally replicating adenoviruses for cancer treatment.
Academic Article Next generation metronomic chemotherapy-report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6-8 May 2016, Mumbai.
Academic Article Modulation of P450-dependent ifosfamide pharmacokinetics: a better understanding of drug activation in vivo.
Academic Article Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.
Academic Article P450 enzyme expression patterns in the NCI human tumor cell line panel.
Academic Article Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).
Academic Article Harnessing apoptosis for improved anticancer gene therapy.
Academic Article Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy.
Academic Article Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy.
Academic Article Hormonal perturbations in patients with testicular cancer treated with cisplatin.
Academic Article Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b.
Academic Article Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.
Academic Article Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model.
Academic Article Depletion of serum growth hormone in adult female rats by neonatal monosodium glutamate treatment without loss of female-specific hepatic enzymes P450 2d (IIC12) and steroid 5 alpha-reductase.
Academic Article Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.
Academic Article Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells.
Academic Article Progress and prospects: gene therapy clinical trials (part 2).
Academic Article Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment.
Academic Article H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity.
Academic Article CpG-1826 immunotherapy potentiates chemotherapeutic and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model.
Academic Article Modulation of thiotepa antitumor activity in vivo by alteration of liver cytochrome P450-catalyzed drug metabolism.
Academic Article Cancer chemotherapy and drug metabolism.
Academic Article Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model.
Academic Article Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.
Academic Article Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib.
Academic Article Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis.
Academic Article N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents.
Academic Article Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators.
Academic Article Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy.
Academic Article Combination of antiangiogenesis with chemotherapy for more effective cancer treatment.
Academic Article Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors.
Academic Article Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model.
Academic Article Cytochrome P450-based cancer gene therapy: recent advances and future prospects.
Academic Article Medium dose intermittent cyclophosphamide induces immunogenic cell death and cancer cell autonomous type I interferon production in glioma models.
Academic Article Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases.
Academic Article Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.
Academic Article Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.
Academic Article Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy.
Academic Article Dual E1A oncolytic adenovirus: targeting tumor heterogeneity with two independent cancer-specific promoter elements, DF3/MUC1 and hTERT.
Academic Article Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard.
Academic Article Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone.
Academic Article Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer.
Academic Article Selection of cytochrome p450 genes for use in prodrug activation-based cancer gene therapy.
Academic Article 7 in vitro methods for evaluation of p450-based anticancer gene therapy.
Academic Article 8 tumor models for evaluation of p450 gene therapy in vivo.
Academic Article PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis.
Academic Article Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib.
Academic Article Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer.
Academic Article Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy.
Academic Article Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation.
Academic Article Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy.
Academic Article Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.
Academic Article In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.
Academic Article Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model.
Academic Article Widespread epigenetic changes to the enhancer landscape of mouse liver induced by a specific xenobiotic agonist ligand of the nuclear receptor CAR.
Academic Article Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts.
Academic Article Cytochrome p450-based gene therapies for cancer.
Academic Article Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy.
Academic Article Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization.
Academic Article Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase.
Academic Article Adenoviral vectors for prodrug activation-based gene therapy for cancer.
Academic Article VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression.
Academic Article Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
Academic Article Gene-specific oligonucleotide probes for alpha, mu, pi, and microsomal rat glutathione S-transferases: analysis of liver transferase expression and its modulation by hepatic enzyme inducers and platinum anticancer drugs.
Academic Article Complete reversal by thaliblastine of 490-fold adriamycin resistance in multidrug-resistant (MDR) human breast cancer cells. Evidence that multiple biochemical changes in MDR cells need not correspond to multiple functional determinants for drug resistance.
Academic Article Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2.
Academic Article Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer.
Academic Article Intermittent metronomic drug schedule is essential for activating antitumor innate immunity and tumor xenograft regression.
Academic Article Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells.
Academic Article Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.
Academic Article Mechanisms of cyclophosphamide action on hepatic P-450 expression.
Academic Article Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models.
Academic Article Antitumor alkylating agents: in vitro cross-resistance and collateral sensitivity studies.
Academic Article Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver.
Academic Article Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+.
Academic Article Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance.
Academic Article Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats.
Academic Article Multiple, functional DBP sites on the promoter of the cholesterol 7 alpha-hydroxylase P450 gene, CYP7. Proposed role in diurnal regulation of liver gene expression.
Academic Article Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.
Academic Article Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene.
Academic Article Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats.
Academic Article Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.
Academic Article Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35.
Academic Article Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer.
Academic Article Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2.
Academic Article Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N',N''-triethylenethiophosphoramide.
Academic Article Antiangiogenesis enhances intratumoral drug retention.
Award or Honor Receipt The Bernard B. Brodie Award in Drug Metabolism for Research
Award or Honor Receipt Damon Runyon-Walter Winchell Cancer Fund Fellowship
Academic Article Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver.
Academic Article Delicate Balances in Cancer Chemotherapy: Modeling Immune Recruitment and Emergence of Systemic Drug Resistance.
Grant Combination Therapies for Cancer Treatment
Grant Epigenetic Actions of Environmental Chemicals

Highlights
Search Criteria
  • Epigenetic
  • therapies
  • cancer