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Search Results to Gary Gilbert, MD

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Research Expertise & Professional Interests Dr. Gary Gilbert, M.D. is the Deputy Associate Chief of Staff for Research and Development at the VA Boston Healthcare System. In his capacity, he oversees the basic science activities at all three campuses and has charge of major initiatives to import new technical capabilities and build a major expansion of the animal facilities He also serves as a member of BVARI’s Board of Directors. Dr. Gilbert is Associate Physician in Medicine, Brigham and Women’s Hospital and the Associate Professor of Medicine, Harvard medical School. His research interests target understanding the mechanisms through which activity of blood coagulation proteins is regulated on cell membranes. He has four categories of research in his laboratory: 1. To study the characterization of the mechanism through which lactadherin binds to membranes and functions as an anticoagulant in vitro. This includes structure-function studies to identify essential features of the interaction. 2. To utilize lactadherin and probes derived from lactadherin to identify procoagulant membranes in vivo and to probe the importance. 3. To identify the functional amino acids on the membrane-interactive C1 and C2 domains of factor VIII. This project may lead to engineering factor VIII so that the product molecule has higher specific activity and a slower rate of clearance. 4. To seek to determine through what mechanisms phospholipid molecules activate the factor VIIIa-factor IXa enzyme complex. This information will provide improved basic insight and, possibly, a novel approach to treatment of hemophilia patients that have developed inhibitory antibodies to factor VIII.

One or more keywords matched the following items that are connected to Gilbert, Gary

Item TypeName
Concept Carrier Proteins
Concept Lipid Bilayers
Concept Membrane Lipids
Concept Membrane Proteins
Concept Milk Proteins
Concept Neoplasm Proteins
Concept Protein Binding
Concept Protein Conformation
Concept Recombinant Fusion Proteins
Concept Recombinant Proteins
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Protein Folding
Concept Reptilian Proteins
Concept Mutant Proteins
Concept Wiskott-Aldrich Syndrome Protein
Concept Protein Interaction Domains and Motifs
Concept Protein Stability
Concept Hydrophobic and Hydrophilic Interactions
Academic Article Crystal structure of lactadherin C2 domain at 1.7A resolution with mutational and computational analyses of its membrane-binding motif.
Academic Article The evolving understanding of factor VIII binding sites and implications for the treatment of hemophilia A.
Academic Article Inhibitory antibodies against factor VIII C1 domain.
Academic Article Thrombotic Role of Blood and Endothelial Cells in Uremia through Phosphatidylserine Exposure and Microparticle Release.
Academic Article Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine.
Academic Article Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.
Academic Article Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells.
Academic Article Endothelial cell phagocytosis of senescent neutrophils decreases procoagulant activity.
Academic Article Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity.
Academic Article Phagocytosis by macrophages and endothelial cells inhibits procoagulant and fibrinolytic activity of acute promyelocytic leukemia cells.
Academic Article Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition.
Academic Article Membrane-binding properties of the Factor VIII C2 domain.
Academic Article A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function.
Academic Article Daunorubicin induces procoagulant activity of cultured endothelial cells through phosphatidylserine exposure and microparticles release.
Academic Article WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling.
Academic Article Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity.
Academic Article Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site.
Academic Article Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs.
Academic Article Lactadherin functions as a probe for phosphatidylserine exposure and as an anticoagulant in the study of stored platelets.
Academic Article Specificity of phosphatidylserine-containing membrane binding sites for factor VIII. Studies with model membranes supported by glass microspheres (lipospheres).
Academic Article Amphipathic helices support function of blood coagulation factor IXa.
Academic Article Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine.
Academic Article Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites.
Academic Article Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature.
Academic Article Lactadherin blocks thrombosis and hemostasis in vivo: correlation with platelet phosphatidylserine exposure.
Academic Article Use of microsphere-supported phospholipid membranes for analysis of protein-lipid interactions.
Academic Article Binding of factor VIII to von willebrand factor is enabled by cleavage of the von Willebrand factor propeptide and enhanced by formation of disulfide-linked multimers.
Academic Article Membrane-binding peptide from the C2 domain of factor VIII forms an amphipathic structure as determined by NMR spectroscopy.
Academic Article Collagen-bound von Willebrand factor has reduced affinity for factor VIII.
Academic Article Lysine 5 and phenylalanine 9 of the factor IX omega-loop interact with phosphatidylserine in a membrane-mimetic environment.
Academic Article Procoagulant activity of erythrocytes and platelets through phosphatidylserine exposure and microparticles release in patients with nephrotic syndrome.
Academic Article Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine.
Academic Article Bovine lactadherin as a calcium-independent imaging agent of phosphatidylserine expressed on the surface of apoptotic HeLa cells.
Academic Article Phosphatidylserine exposure and procoagulant activity in acute promyelocytic leukemia.
Academic Article Structure and topography of the membrane-binding C2 domain of factor VIII in the presence of dodecylphosphocholine micelles.
Academic Article Phosphatidylethanolamine induces high affinity binding sites for factor VIII on membranes containing phosphatidyl-L-serine.
Academic Article Unsaturated phospholipid acyl chains are required to constitute membrane binding sites for factor VIII.
Academic Article Partial activation of the factor VIIIa-factor IXa enzyme complex by dihexanoic phosphatidylserine at submicellar concentrations.
Academic Article Membrane phosphatidylserine regulates surface charge and protein localization.
Academic Article Lactadherin detects early phosphatidylserine exposure on immortalized leukemia cells undergoing programmed cell death.

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