Search Results to Hans Dooms, PhD

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One or more keywords matched the following properties of Dooms, Hans

Person ID 2122
phone 617.414.2506
Research Expertise & Professional Interests The broad goal of my research is to understand the role of T cells in the pathogenesis of autoimmune diseases and to apply this knowledge for the development of new therapeutic interventions. My laboratory uses in vivo models of autoimmune diseases to follow T cell responses against tissues (e.g. pancreatic islets) and to identify molecules (e.g. cytokines) that orchestrate the autoimmune attack. In addition, we are developing novel gene-deficient and transgenic models to obtain mechanistic insights into the cytokine signaling pathways and transcription factors that drive autoreactive T cells. To combine the capacity for potent protective responses against pathogens with the prevention of autoimmunity and tissue damage, the immune system works with “checks and balances” to generate the appropriate cellular response to foreign antigens while maintaining tolerance to self. Autoimmune diseases result from breakdowns of these control mechanisms, either due to defects in tolerance-inducing pathways or because autoreactive lymphocytes acquire resistance to proper regulation. I am particularly interested in the contribution of one type of lymphocytes, memory T cells, to the autoimmune process. Memory T cells possess superior effector capacity and long-term viability to fulfill their physiologic function of protecting the host against recurring infections and tumors. However, memory T cells that develop against self-antigens are, precisely due to these characteristics, a significant clinical problem and a major obstacle to restoring tolerance for the therapy of autoimmune diseases and the protection of transplants. We are currently studying type 1 diabetes as a model of autoimmunity. Islet-specific memory T cells are present in animal models as well as patients with type 1 diabetes and perpetuate anti-islet immune responses, ultimately leading to the onset of hyperglycemia. We recently found that blocking the cytokine Interleukin-7 (IL-7) inhibits these pathogenic memory cells and stops further destruction of the insulin-producing cells in the pancreas. Cytokines such as IL-7 and IL-2 are important regulators for the differentiation, programming and maintenance of memory T cells and modulating their function is a promising approach for controlling memory responses. Ongoing projects in the lab focus on (1) elucidating the molecular and cellular mechanisms underlying IL-7’s role in type 1 diabetes, (2) understanding the dual function of IL-2 in immunity and tolerance and (3) identifying transcriptional programs in CD4+ memory T cells.
Self-Described Keywords type 1 diabetes

One or more keywords matched the following items that are connected to Dooms, Hans

Item TypeName
Concept Adenosine Triphosphate
Concept Algorithms
Concept Antibodies, Monoclonal
Concept Antigens, Differentiation
Concept Antigens, Differentiation, T-Lymphocyte
Concept Cell Differentiation
Concept Cell Division
Concept Cell Line
Concept Cell Line, Transformed
Concept Cell Separation
Concept Cell Survival
Concept Cells, Cultured
Concept Clone Cells
Concept Cytochrome c Group
Concept Diabetes Mellitus, Type 1
Concept Diabetes Mellitus, Type 2
Concept Disease Models, Animal
Concept DNA Replication
Concept Etoposide
Concept Extracellular Space
Concept Flow Cytometry
Concept Immunization
Concept Injections, Intraperitoneal
Concept Interferon-gamma
Concept Interleukin-2
Concept Interphase
Concept Leukocytes, Mononuclear
Concept Lymphocyte Activation
Concept Lymphocytes
Concept Membrane Potentials
Concept Mitochondria
Concept Ovalbumin
Concept Pneumonia, Pneumococcal
Concept Chondroitin Sulfate Proteoglycans
Concept T-Lymphocytes
Concept Tumor Cells, Cultured
Concept Tumor Necrosis Factor-alpha
Concept Vaccination
Concept Vaccinia virus
Concept Antigens, Tumor-Associated, Carbohydrate
Concept Signal Transduction
Concept CD4-Positive T-Lymphocytes
Concept Antigens, CD
Concept Interleukin-7
Concept Immunophenotyping
Concept T-Lymphocyte Subsets
Concept G0 Phase
Concept Cytokines
Concept Cyclosporine
Concept Mitomycin
Concept Cell Death
Concept Apoptosis
Concept Antigens, CD3
Concept Receptor-CD3 Complex, Antigen, T-Cell
Concept Antigens, CD28
Concept CD8-Positive T-Lymphocytes
Concept Th1 Cells
Concept Th2 Cells
Concept Lymphocyte Count
Concept Antigens, CD95
Concept Cell Lineage
Concept Oleic Acid
Concept Interleukin-15
Concept Genetic Predisposition to Disease
Concept Interleukin-17
Concept Receptors, Interleukin-7
Concept CD40 Ligand
Concept Cell Proliferation
Concept T-Lymphocytes, Regulatory
Concept STAT5 Transcription Factor
Concept Forkhead Transcription Factors
Concept 4-1BB Ligand
Concept Interleukin-2 Receptor alpha Subunit
Concept Interleukin-2 Receptor beta Subunit
Concept Versicans
Concept Interleukin-7 Receptor alpha Subunit
Concept Metabolomics
Concept Bacterial Load
Concept Programmed Cell Death 1 Receptor
Academic Article Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4+ T cell responsiveness to antigen.
Academic Article Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.
Academic Article Interleukin-15 redirects the outcome of a tolerizing T-cell stimulus from apoptosis to anergy.
Academic Article Life and death in effector T cells.
Academic Article Induction of IL-15 by TCR/CD3 aggregation depends on IFN-gamma and protects against apoptosis of immature thymocytes in vivo.
Academic Article Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo.
Academic Article IL-2 induces a competitive survival advantage in T lymphocytes.
Academic Article Control of CD4+ T-cell memory by cytokines and costimulators.
Academic Article Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells.
Academic Article Targeting T cell-specific costimulators and growth factors in a model of autoimmune hemolytic anemia.
Academic Article Interleukin-2 in the development and control of inflammatory disease.
Academic Article The initial phase of an immune response functions to activate regulatory T cells.
Academic Article Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells.
Academic Article Revisiting the role of IL-2 in autoimmunity.
Academic Article Opposing functions of IL-2 and IL-7 in the regulation of immune responses.
Academic Article IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.
Academic Article IL-15 augments TCR-induced CD4+ T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4+ T cells.
Academic Article A converse 4-1BB and CD40 ligand expression pattern delineates activated regulatory T cells (Treg) and conventional T cells enabling direct isolation of alloantigen-reactive natural Foxp3+ Treg.
Academic Article Interleukin-7: Fuel for the autoimmune attack.
Academic Article Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis.
Academic Article Broad induction of immunoregulatory mechanisms after a short course of anti-IL-7Ra antibodies in NOD mice.
Academic Article Regionally compartmentalized resident memory T cells mediate naturally acquired protection against pneumococcal pneumonia.
Academic Article Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells.
Academic Article Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD-1, TIGIT, and TIM-3 in Lymphocytes From Patients With Systemic Sclerosis.
Academic Article Combining anti-IL-7Ra antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes.
Academic Article Pneumonia recovery reprograms the alveolar macrophage pool.
Grant Inhibiting Autoreactive Memory T Cells in Type 1 Diabetes
Grant BADERC: Dysregulated cellular metabolism predisposes to Type 1 Diabetes
Grant Mechanisms underlying the role of Interleukin-7 in Type 1 Diabetes

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  • Diabetes