Search Results to Jeffrey M. Drazen, MD

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Research Expertise & Professional Interests Jeffrey M. Drazen, M.D., joined the New England Journal of Medicine (NEJM) as editor-in-chief in July of 2000. At NEJM, Dr. Drazen’s responsibilities include oversight of all editorial content and policies. His editorial background includes service as an associate editor or editorial board member for the Journal of Clinical Investigation, the American Journal of Respiratory Cell and Molecular Biology, and the American Journal of Medicine. A specialist in pulmonology, Dr. Drazen maintains an active research program. Dr. Drazen has published hundreds of articles on topics such as lung physiology and the mechanisms involved in asthma. In 1999, he delivered the Amberson Lecture, the major research address at the annual meeting of the American Thoracic Society. In 2000, he received the Chadwick Medal from the Massachusetts Thoracic Society for his contributions to the study of lung disease. Dr. Drazen is the Distinguished Parker B. Francis Professor of Medicine at Harvard Medical School, professor of physiology at the Harvard School of Public Health, senior physician at Brigham and Women’s Hospital, and adjunct professor of medicine at the Boston University School of Medicine. In 2003, he was elected as a member of the Institute of Medicine. Dr. Drazen has served on numerous committees for the National Institutes of Health, including the Respiratory and Applied Physiology Study Section; the Lung Biology and Pathology Study Section; the Pulmonary Disease Advisory Council; the National Heart, Lung, and Blood Institute Advisory Council; the Public Access Working Group; and the National Heart, Lung, and Blood Institute’s Division of Lung Disease Executive Planning Committee. He has also served on the Veterans’ Administration National Research Advisory Committee. He currently serves on the Global Initiative for Asthma Science Committee, the World Health Organization’s Scientific Advisory Group on Clinical Trials Registration, and co-chairs the Institute of Medicine’s Forum on Drug Discovery, Development, and Translation. Dr. Drazen earned his bachelor’s degree and graduated summa cum laude from Tufts University. He received his medical degree from Harvard Medical School and completed his internship and residency at Peter Bent Brigham Hospital in Boston. Dr. Drazen has received honorary degrees from the University of Ferrara, Italy, and the National and Kapodistrian University of Athens, Greece. A native of Missouri, Dr. Drazen lives with his wife in Winchester, Massachusetts. They are the parents of two grown sons.
Self-Described Keywords asthma

One or more keywords matched the following items that are connected to Drazen, Jeffrey

Item TypeName
Concept Asthma
Concept Asthma, Exercise-Induced
Concept Biomarkers, Tumor
Academic Article The pivotal role of 5-lipoxygenase products in the reaction of aspirin-sensitive asthmatics to aspirin.
Academic Article Diurnal variation of urinary leukotriene E4 and histamine excretion rates in normal subjects and patients with mild-to-moderate asthma.
Academic Article Neuropeptide content of lungs from asthmatic and nonasthmatic patients.
Academic Article Progress at the interface of inflammation and asthma. Report of an ATS-sponsored workshop November, 1993.
Academic Article Inflammatory effector mechanisms in asthma.
Academic Article Treatment of chronic stable asthma with drugs active on the 5-lipoxygenase pathway.
Academic Article Expired nitric oxide levels during treatment of acute asthma.
Academic Article Role of cysteinyl leukotrienes in spontaneous asthmatic responses.
Academic Article Chemical regulation of pulmonary airway tone.
Academic Article Clinical studies with agents active on the 5-lipoxygenase pathway.
Academic Article Direct evidence for a role of the mast cell in the nasal response to aspirin in aspirin-sensitive asthma.
Academic Article Airway wall liquid. Sources and role as an amplifier of bronchoconstriction.
Academic Article The effect of inhibition of 5-lipoxygenase by zileuton in mild-to-moderate asthma.
Academic Article Sorting out the cytokines of asthma.
Academic Article Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network.
Academic Article Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network.
Academic Article Beta 2 adrenoceptor polymorphisms.
Academic Article Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription.
Academic Article T-lymphocytes regulate genetically determined airway hyperresponsiveness in mice.
Academic Article Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group.
Academic Article Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects.
Academic Article Pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors in the management of asthma.
Academic Article Genetics of airway responsiveness in the inbred mouse.
Academic Article Antileukotrienes in the treatment of asthma.
Academic Article On the mechanism of mucosal folding in normal and asthmatic airways.
Academic Article Genetics of asthma: conference summary.
Academic Article An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network.
Academic Article Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast.
Academic Article New directions in asthma drug therapy.
Academic Article Inflammatory cell distribution within and along asthmatic airways.
Academic Article Leukotrienes as mediators of airway obstruction.
Academic Article Should antileukotriene therapies be used instead of inhaled corticosteroids in asthma? Yes.
Academic Article Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma.
Academic Article Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment.
Academic Article Churg-Strauss syndrome.
Academic Article Mutations in the human 5-lipoxygenase gene.
Academic Article Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma.
Academic Article Inflammation and airway function in asthma: what you see is not necessarily what you get.
Academic Article Expired nitric oxide after bronchoprovocation and repeated spirometry in patients with asthma.
Academic Article Agonist-induced lipoxin A4 generation in vitro and in aspirin-sensitive asthmatics: detection by a novel lipoxin A4-ELISA.
Academic Article Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors.
Academic Article Treatment of asthma with drugs modifying the leukotriene pathway.
Academic Article Pharmacogenetics of the 5-lipoxygenase pathway in asthma.
Academic Article Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice.
Academic Article Animal models of asthma and chronic bronchitis.
Academic Article Zafirlukast and Churg-Strauss syndrome.
Academic Article Leukotriene modifiers and Churg-Strauss syndrome: adverse effect or response to corticosteroid withdrawal?
Academic Article Elevated plasma eotaxin levels in patients with acute asthma.
Academic Article Neuronal NO synthase (NOS1) is a major candidate gene for asthma.
Academic Article Eotaxin and impaired lung function in asthma.
Academic Article Asthma therapy with agents preventing leukotriene synthesis or action.
Academic Article Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice.
Academic Article Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma.
Academic Article A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma.
Academic Article Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents.
Academic Article Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism.
Academic Article The utility of peak flow, symptom scores, and beta-agonist use as outcome measures in asthma clinical research.
Academic Article Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma.
Academic Article Automated detection of single nucleotide polymorphism in beta-2 adrenergic receptor gene using LCx(R).
Academic Article Exhaled nitric oxide following repeated spirometry or repeated plethysmography in healthy individuals.
Academic Article 5' flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States.
Academic Article The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma.
Academic Article Exhaled nitric oxide in patients with asthma: association with NOS1 genotype.
Academic Article Clinical predictors of health-related quality of life depend on asthma severity.
Academic Article Heterogeneity of therapeutic responses in asthma.
Academic Article Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial.
Academic Article Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial.
Academic Article Association of asthma with beta(2)-adrenergic receptor gene polymorphism and cigarette smoking.
Academic Article Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study.
Academic Article DNA sequence variants of the platelet-derived growth factor A-chain gene.
Academic Article Beta(2)-adrenoceptor polymorphism and body mass index are associated with adult-onset asthma in sedentary but not active women.
Academic Article The clinical trials in the initial five-year award period of the Asthma Clinical Research Network.
Academic Article Genetic analysis in the Asthma Clinical Research Network.
Academic Article Recovery of leukotriene E4 from the urine of patients with airway obstruction.
Academic Article Mechanical stimuli to airway remodeling.
Academic Article Variant eotaxin: its effects on the asthma phenotype.
Academic Article Systemic effect comparisons of six inhaled corticosteroid preparations.
Academic Article Genetics: inherit the wheeze.
Academic Article Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4).
Academic Article Exhaled nitric oxide: a marker of pulmonary hemodynamics in heart failure.
Academic Article DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma.
Academic Article Asthma and the human genome project: summary of the 45th Annual Thomas L. Petty Aspen Lung Conference.
Academic Article Anti-leukotrienes as novel anti-inflammatory treatments in asthma.
Academic Article Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels.
Academic Article Leukotrienes in asthma.
Academic Article LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter.
Academic Article Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.
Academic Article Significant variability in response to inhaled corticosteroids for persistent asthma.
Academic Article The pharmacogenetics of asthma: a candidate gene approach.
Academic Article Pharmacogenetics of asthma.
Academic Article Acetazolamide and furosemide attenuate asthma induced by hyperventilation of cold, dry air.
Academic Article Exhaled nitric oxide as a diagnostic test for asthma: online versus offline techniques and effect of flow rate.
Academic Article Sequence variants in the FcepsilonRI alpha chain gene.
Academic Article Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program.
Academic Article Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium.
Academic Article Immunostimulatory DNA for asthma: better than eating dirt.
Academic Article Changes in cross-sectional airway areas induced by methacholine, histamine, and LTC4 in asthmatic subjects.
Academic Article Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program.
Academic Article Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma.
Academic Article Airway hyperresponsiveness and airway wall thickening in asthma. A quantitative approach.
Academic Article Beta-agonists and asthma: too much of a good thing?
Academic Article A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha.
Academic Article Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness.
Academic Article Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids.
Academic Article Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma.
Academic Article Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial.
Academic Article TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.
Academic Article CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma.
Academic Article Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses.
Academic Article Asthma: a solution to half the puzzle?
Academic Article Interacting genetic loci cause airway hyperresponsiveness.
Academic Article Asthma: one hundred years of treatment and onward.
Academic Article Breathing pattern affects respiratory heat loss but not bronchoconstrictor response in asthma.
Academic Article Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells.
Academic Article Acorns and inhalers: the Asthma Clinical Research Network.
Academic Article Clinical Decisions. Mild persistent asthma--polling results.
Academic Article Global strategy for asthma management and prevention: GINA executive summary.
Academic Article Risks of long-acting beta-agonists in achieving asthma control.
Academic Article Choosing asthma step-up care.
Academic Article Genetics and pharmacogenetics of the leukotriene pathway.
Academic Article The safety of long-acting beta-agonists: more evidence is needed.
Academic Article Comparative contractile responses to sulfidopeptide leukotrienes in normal and asthmatic human subjects.
Academic Article The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress.
Academic Article Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma.
Academic Article Products at risk.
Academic Article Distribution of pulmonary responsiveness to aerosol histamine in dogs.
Academic Article A step toward personalized asthma treatment.
Academic Article Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects.
Academic Article Asthma treatment guidelines meet the real world.
Academic Article The functional conversion hypothesis: a contributor to exercise-induced asthma?
Academic Article Dissociation of temperature-gradient and evaporative heat loss during cold gas hyperventilation in cold-induced asthma.
Academic Article Asthma: the paradox of heterogeneity.
Academic Article Tissue factor-bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo.
Academic Article A patient with asthma seeks medical advice in 1828, 1928, and 2012.
Academic Article The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air.
Academic Article NHLBI Workshop Summary. Models of airway hyperresponsiveness.
Academic Article Localization of the site of the bronchoconstrictor effects of leukotriene C4 compared with that of histamine in asthmatic subjects.
Academic Article Effect of a leukotriene antagonist, LY171883, on cold air-induced bronchoconstriction in asthmatics.
Academic Article Heterogeneity of leukotriene C4 production by eosinophils from asthmatic and from normal subjects.
Academic Article Inhalation challenge with sulfidopeptide leukotrienes in human subjects.
Academic Article Airway effects of monosodium glutamate in subjects with chronic stable asthma.
Academic Article The pathogenesis of severe asthma: a consensus report from the Workshop on Pathogenesis.
Academic Article Pulmonary response to antigen infusion in the sensitized guinea pig: modification by atropine.
Academic Article Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors.
Academic Article Indomethacin potentiates the pulmonary response to aerosol leukotriene C4 in the guinea pig.
Academic Article Finite difference analysis of respiratory heat transfer.
Academic Article Effects of leukotriene D on the airways in asthma.
Academic Article Calcium blockers and bronchoconstriction.
Academic Article Histamine and nocturnal wheezing.
Academic Article Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice.
Academic Article Effect of chronic 5-lipoxygenase inhibition on airway hyperresponsiveness in asthmatic subjects.
Academic Article Treating mild asthma--when are inhaled steroids indicated?
Academic Article The influence of age, diagnosis, and gender on proper use of metered-dose inhalers.
Academic Article Agonist-induced lipoxin A4 generation: detection by a novel lipoxin A4-ELISA.
Academic Article Unjamming and cell shape in the asthmatic airway epithelium.
Academic Article Putting the Squeeze on Airway Epithelia.
Academic Article Compressive Stress Causes an Unjamming Transition and an Epithelial-Mesenchymal Transition in the Airway Epithelium in Asthma.
Academic Article A summary of the new GINA strategy: a roadmap to asthma control.
Academic Article More on Data Sharing.
Academic Article Data Sharing.
Academic Article New Biologics for Asthma.
Academic Article Mechanical forces induce an asthma gene signature in healthy airway epithelial cells.

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