Search Results to Thomas Kepler, PhD

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One or more keywords matched the following properties of Kepler, Thomas

Research Expertise & Professional Interests The Kepler laboratory develops computational tools and applies them in the context of systems-level experimentation to address outstanding questions in immunology and vaccine development. Much of their work is centered on antibodies and the cells (B cells) that produce them. Antibodies are genetically extraordinary: their genes are encoded only as fragments in the genome. The B cell’s genome must be cut, rearranged and re-ligated in several places to make the genes required for antibody production. Furthermore, after a B cell has encountered a molecule that binds its antibody (whether on a pathogen, an infected cell, a cancerous tumor, or, in the case of autoimmune disease, normal tissue) the B cell directs mutations into its rearranged antibody genes, and is then subject to competitive selection for improved ability to bind the eliciting molecule. In this Darwinian process, known as affinity maturation, the antibody response is rapidly improved and prepared as the memory response that confers long-term immunity and serves as the basis for vaccination. The Kepler group works with multiple collaborating laboratories to generate and integrate data from many different assays, each of which provides one perspective on the workings of affinity maturation. By using computational means to coordinate the integration of these diverse data, a comprehensive picture of the process at a systems level emerges. Professor Kepler, in partnership with colleagues at Duke and Harvard Universities, has developed a new approach to vaccination that uses computational methods to select combinations of immunogens to use in vaccines that drive affinity maturation in specific directions. These methods are being used to develop vaccines against HIV, influenza, and anthrax.
Self-Described Keywords computational biology
Self-Described Keywords Computational Immunology

One or more keywords matched the following items that are connected to Kepler, Thomas

Item TypeName
Concept Administration, Intranasal
Concept Administration, Oral
Concept Algorithms
Concept Antibodies, Antinuclear
Concept Arthrography
Concept Biopsy
Concept Cell Separation
Concept Chromosome Mapping
Concept Clinical Trials as Topic
Concept Cloning, Molecular
Concept Computer Graphics
Concept Computer Simulation
Concept Cross-Sectional Studies
Concept Cytotoxicity Tests, Immunologic
Concept DNA Mutational Analysis
Concept Double-Blind Method
Concept Electric Stimulation
Concept Electrophoresis, Polyacrylamide Gel
Concept Enzyme-Linked Immunosorbent Assay
Concept Evaluation Studies as Topic
Concept Flow Cytometry
Concept Hemagglutination Inhibition Tests
Concept Image Processing, Computer-Assisted
Concept Immunization
Concept Immunization, Secondary
Concept Immunoassay
Concept Immunohistochemistry
Concept Injections, Intramuscular
Concept Injections, Intravenous
Concept Interferometry
Concept Leukocyte Count
Concept Lymphocyte Culture Test, Mixed
Concept Longitudinal Studies
Concept Lymphocyte Activation
Concept Microscopy, Electron
Concept Models, Theoretical
Concept Monte Carlo Method
Concept Neutralization Tests
Concept Pilot Projects
Concept Prognosis
Concept Research
Concept Spectrometry, X-Ray Emission
Concept Statistics as Topic
Concept Surgical Procedures, Operative
Concept Transplantation, Homologous
Concept User-Computer Interface
Concept Vaccination
Concept Blotting, Southern
Concept Protein Engineering
Concept Cohort Studies
Concept Logistic Models
Concept Skin Transplantation
Concept Immunophenotyping
Concept Polymerase Chain Reaction
Concept Sequence Alignment
Concept Sequence Analysis, DNA
Concept Crystallography, X-Ray
Concept Epitope Mapping
Concept CD4 Lymphocyte Count
Concept Coculture Techniques
Concept Cell Culture Techniques
Concept Fluorescent Antibody Technique, Indirect
Concept Adoptive Transfer
Concept Computational Biology
Concept Amino Acid Substitution
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Surface Plasmon Resonance
Concept Oligonucleotide Array Sequence Analysis
Concept Sequence Analysis, Protein
Concept Comet Assay
Concept Gene Expression Profiling
Concept Protein Array Analysis
Concept Gene Knock-In Techniques
Concept High-Throughput Screening Assays
Concept Molecular Docking Simulation
Academic Article Modeling and optimization of populations subject to time-dependent mutation.
Academic Article Genetic plasticity of V genes under somatic hypermutation: statistical analyses using a new resampling-based methodology.
Academic Article The targeting of somatic hypermutation closely resembles that of meiotic mutation.
Academic Article Improved inference of mutation rates: II. Generalization of the Luria-Delbrück distribution for realistic cell-cycle time distributions.
Academic Article Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood.
Academic Article Statistical inference of sequence-dependent mutation rates.
Academic Article Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations.
Academic Article Identification and utilization of arbitrary correlations in models of recombination signal sequences.
Academic Article Diversification of Ig superfamily genes in an invertebrate.
Academic Article Statistical analysis of antigen receptor spectratype data.
Academic Article Identifying differential expression in multiple SAGE libraries: an overdispersed log-linear model approach.
Academic Article SoDA: implementation of a 3D alignment algorithm for inference of antigen receptor recombinations.
Academic Article SpA: web-accessible spectratype analysis: data management, statistical analysis and visualization.
Academic Article Computational immunology--from bench to virtual reality.
Academic Article Spatiotemporal programming of a simple inflammatory process.
Academic Article An information-theoretic method for the treatment of plural ancestry in phylogenetics.
Academic Article Improving peptide-MHC class I binding prediction for unbalanced datasets.
Academic Article High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies.
Academic Article The dynamics of T-cell receptor repertoire diversity following thymus transplantation for DiGeorge anomaly.
Academic Article Patient socioeconomic status is an independent predictor of operative mortality.
Academic Article Spatial Mixture Modelling for Unobserved Point Processes: Examples in Immunofluorescence Histology.
Academic Article Chiropteran types I and II interferon genes inferred from genome sequencing traces by a statistical gene-family assembler.
Academic Article A Bayesian approach for estimating calibration curves and unknown concentrations in immunoassays.
Academic Article A model for migratory B cell oscillations from receptor down-regulation induced by external chemokine fields.
Academic Article Computational implications of a serotonin-sensitive region of axonal membrane on a dual-function motor neuron
Academic Article Mixtures of Gaussian Wells: Theory, Computation, and Application.
Academic Article Surface plasmon resonance measurements of plasma antibody avidity during primary and secondary responses to anthrax protective antigen.
Academic Article Bayesian Estimation of the Active Concentration and Affinity Constants Using Surface Plasmon Resonance Technology.
Academic Article Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.
Academic Article Genetic and structural analyses of affinity maturation in the humoral response to HIV-1.

Search Criteria
  • Bayesian
  • Methods
  • Computing
  • Algorithms