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Research Expertise & Professional Interests Vasan S. Ramachandran, M.D., Principal Investigator and Director of the FHS, and Director of the FHS fellowship program in cardiovascular epidemiology for the last 25 years. Dr. Ramachandran is a Professor of Medicine and Epidemiology at BUSM/BUSPH, and Chief, Section of Preventive Medicine and Epidemiology, Department of Medicine, BUSM. He is the Jay & Louis Coffman Professor of Vascular Medicine at BUSM. Dr. Ramachandran is a trained cardiologist with subspecialty training in echocardiography. He is a fellow of the AHA Councils on Epidemiology and Prevention and Functional Genomics and Translational Biology, and a fellow of the American College of Cardiology (ACC). He has extensive experience in supervising trainees at many levels and has taught the foundational core course on Cardiovascular Epidemiology at BUSPH (EP751). He has several active R01 grants from the NHLBI/NIDDK and received two K24 Mid-Career Investigator mentoring grants from the NHLBI. He has mentored several K23 awardees, and is currently the Principal Investigator of a post-doctoral training program (T32) in cardiovascular epidemiology. Overall, he has supervised over 70 trainees during the past 20 years; most are in key positions in academia. He received the Outstanding Mentor awards from the Department of Medicine, BUSM, and the AHA Council on Epidemiology and Prevention, and the prestigious AHA Population Science Award in 2014. Importantly, Dr. Ramachandran’s own peer-reviewed funding spans thematic areas of genetics and genomics, cardiac and vascular remodeling, novel biomarkers, systems biology including proteomics and metabolomics, and stem cell biology. He has a 25-year history in research in cardiovascular epidemiology, including the two years he trained as a FHS fellow (1993-1995). He established the first School of Public Health in India between 1996-1998, serving as its inaugural director and the coordinator of its MPH program. He is the founding member and leader of the international EchoGen consortium, and chairs the Steering Committee of the Chronic Kidney Disease Biomarker Consortium funded by the NIDDK (U01DK085689). He is recognized internationally for translational research in cardiovascular epidemiology and lectures regularly at the AHA early career session on “how to develop a career in translational research and epidemiology/genetics.” He is well equipped to mentor trainees about grant writing having been a member of the Cardiovascular and Sleep (CASE) SRG, and an active reviewer of grants for national and international funding agencies. He served for many years on the NHLBI panel for reviewing K23-K24-K25 career development grants. He is well qualified to mentor trainees in best publication practices and has served until recently as an Associate Editor for Circulation, and the Editor-in-Chief of Circulation: Cardiovascular Genetics. He works directs the Center for Integrative Transdisciplinary Epidemiology within BUSM, that hosts multiple epidemiological datasets, including from multiple cohort studies, national surveys (NHANES), administrative databases and electronic health records; this center will be a valuable data source for trainees. For the last 20 years, Dr. Ramachandran has focused his research on A) the genetic and non-genetic epidemiology of congestive heart failure, including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic and diastolic dysfunction, and evaluating the role of LV remodeling; B) population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function; normative standards; detailed assessment of biomarkers of the process of LV remodeling, including but not limited to role of natriuretic peptides, insulin resistance, cardiac extracellular matrix markers, oxidative stress, inflammation, growth factors; genetics of LV remodeling, LA and aortic structure and gene-environment interactions; brachial artery endothelial function, its correlates and tonometric assessment of large artery function; C) genetic and non-genetic epidemiology of high blood pressure, including characterizing the lifetime risk, rates of progression and risks associated with various degrees of elevation; large artery stiffness and function and role in systolic hypertension in the elderly; genetics of high blood pressure and large artery function; and D) CVD risk estimation in the short, medium- and long-term, with novel biomarkers including genomic biomarkers.

One or more keywords matched the following items that are connected to Ramachandran, Vasan

Item TypeName
Concept Acute-Phase Proteins
Concept Blood Proteins
Concept C-Reactive Protein
Concept Carrier Proteins
Concept DNA-Binding Proteins
Concept Lipid Metabolism, Inborn Errors
Concept Lipids
Concept Membrane Proteins
Concept Muscle Proteins
Concept Neoplasm Proteins
Concept Nerve Tissue Proteins
Concept Nuclear Proteins
Concept Protein Precursors
Concept Proteins
Concept Proteinuria
Concept Proto-Oncogene Proteins
Concept Repressor Proteins
Concept Vitamin D-Binding Protein
Concept Extracellular Matrix Proteins
Concept Protein Tyrosine Phosphatases
Concept Protein Structure, Tertiary
Concept Homeodomain Proteins
Concept HSP70 Heat-Shock Proteins
Concept Insulin-Like Growth Factor Binding Proteins
Concept Insulin-Like Growth Factor Binding Protein 3
Concept Son of Sevenless Proteins
Concept Tumor Suppressor Proteins
Concept MADS Domain Proteins
Concept Vesicular Transport Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept Telomere-Binding Proteins
Concept Parathyroid Hormone-Related Protein
Concept Intracellular Signaling Peptides and Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Phospholipid Transfer Proteins
Concept Lipid Metabolism
Concept Fatty Acid-Binding Proteins
Concept Apoptosis Regulatory Proteins
Concept Actin-Related Protein 2-3 Complex
Concept Cholesterol Ester Transfer Proteins
Concept Interleukin 1 Receptor Antagonist Protein
Concept Protein Interaction Domains and Motifs
Concept Retinol-Binding Proteins, Plasma
Concept Protein Multimerization
Concept MARVEL Domain-Containing Proteins
Concept Myelin and Lymphocyte-Associated Proteolipid Proteins
Academic Article Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study.
Academic Article Heritability and genetic linkage of plasma natriuretic peptide levels.
Academic Article Impact of obesity on plasma natriuretic peptide levels.
Academic Article Plasma natriuretic peptide levels and the risk of cardiovascular events and death.
Academic Article Impact of obesity on the risk of heart failure and survival after the onset of heart failure.
Academic Article Novel markers for heart failure diagnosis and prognosis.
Academic Article CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study.
Academic Article Cross-sectional correlates of serum heat shock protein 70 in the community.
Academic Article Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study.
Academic Article Circulating biomarkers of extracellular matrix remodeling and risk of atherosclerotic events.
Academic Article Association of educational level with inflammatory markers in the Framingham Offspring Study.
Academic Article Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
Academic Article Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study.
Academic Article Multiple biomarkers for the prediction of first major cardiovascular events and death.
Academic Article Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level.
Academic Article Relations of inflammation and novel risk factors to valvular calcification.
Academic Article Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals.
Academic Article Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study.
Academic Article Clinical utility of different lipid measures for prediction of coronary heart disease in men and women.
Academic Article Genetic and non-genetic correlates of vitamins K and D.
Academic Article Burden and rates of treatment and control of cardiovascular disease risk factors in obesity: the Framingham Heart Study.
Academic Article Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study).
Academic Article Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart Study.
Academic Article Inflammatory markers and the risk of Alzheimer disease: the Framingham Study.
Academic Article The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases.
Academic Article Thyroid function and lipid subparticle sizes in patients with short-term hypothyroidism and a population-based cohort.
Academic Article Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study.
Academic Article Commentary: C-reactive protein and risk prediction--moving beyond associations to assessing predictive utility and clinical usefulness.
Academic Article Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study.
Academic Article Resistin, adiponectin, and risk of heart failure the Framingham offspring study.
Academic Article Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring.
Academic Article Relations of biomarkers representing distinct biological pathways to left ventricular geometry.
Academic Article Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study.
Academic Article Long-term C-reactive protein variability and prediction of metabolic risk.
Academic Article Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly.
Academic Article Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community.
Academic Article NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.
Academic Article Relation of multiple inflammatory biomarkers to incident atrial fibrillation.
Academic Article Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
Academic Article Major lipids, apolipoproteins, and risk of vascular disease.
Academic Article Interpreting metabolomic profiles using unbiased pathway models.
Academic Article LDL Particle Number and Risk of Future Cardiovascular Disease in the Framingham Offspring Study - Implications for LDL Management.
Academic Article Relations of lipid concentrations to heart failure incidence: the Framingham Heart Study.
Academic Article Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community.
Academic Article Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms.
Academic Article C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.
Academic Article Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators.
Academic Article Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
Academic Article Cross-sectional relations of lipid concentrations to left ventricular structural attributes.
Academic Article A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.
Academic Article Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community.
Academic Article Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.
Academic Article Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies.
Academic Article Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.
Academic Article Hemodynamic correlates of blood pressure across the adult age spectrum: noninvasive evaluation in the Framingham Heart Study.
Academic Article Multimarker approach for the prediction of heart failure incidence in the community.
Academic Article A multi-marker approach to predict incident CKD and microalbuminuria.
Academic Article Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.
Academic Article Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
Academic Article Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans.
Academic Article Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-aged adults: the Framingham Offspring Study.
Academic Article Genetic determinants of serum testosterone concentrations in men.
Academic Article Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium.
Academic Article Circulating plasma cholesteryl ester transfer protein activity and blood pressure tracking in the community.
Academic Article Heart failure: pentraxin 3—a marker of diastolic dysfunction and HF?
Academic Article Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community.
Academic Article Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
Academic Article Next-generation genome-wide association studies: time to focus on phenotype?
Academic Article Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.
Academic Article Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study.
Academic Article Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study.
Academic Article Circulating vascular growth factors and central hemodynamic load in the community.
Academic Article Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study.
Academic Article Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study.
Academic Article C-reactive protein, fibrinogen, and cardiovascular disease prediction.
Academic Article Relation between soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I and incident atrial fibrillation.
Academic Article Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors.
Academic Article Plasma lipid transfer proteins and cardiovascular disease. The Framingham Heart Study.
Academic Article Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study.
Academic Article Vascular inflammation and sleep disordered breathing in a community-based cohort.
Academic Article Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community.
Academic Article Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
Academic Article Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis.
Academic Article Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans.
Academic Article Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
Academic Article Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus.
Academic Article Urinary monocyte chemoattractant protein-1 and hepcidin and early diabetic nephropathy lesions in type 1 diabetes mellitus.
Academic Article Mining the human phenome using allelic scores that index biological intermediates.
Academic Article Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.
Academic Article Genome-wide association study of L-arginine and dimethylarginines reveals novel metabolic pathway for symmetric dimethylarginine.
Academic Article Biomarkers of cardiovascular stress and subclinical atherosclerosis in the community.
Academic Article A multi-step, dynamic allosteric model of testosterone''s binding to sex hormone binding globulin.
Academic Article Genome-wide association study for endothelial growth factors.
Academic Article Integrative network analysis reveals molecular mechanisms of blood pressure regulation.
Academic Article Aldosterone, C-reactive protein, and plasma B-type natriuretic peptide are associated with the development of metabolic syndrome and longitudinal changes in metabolic syndrome components: findings from the Jackson Heart Study.
Academic Article A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study.
Academic Article Long-term risk of cardiovascular events across a spectrum of adverse major plasma lipid combinations in the Framingham Heart Study.
Academic Article Biomarkers of Vitamin D Status and Risk of ESRD.
Academic Article Assessing the incremental predictive performance of novel biomarkers over standard predictors.
Academic Article B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk: the CHARGE-AF Consortium of community-based cohort studies.
Academic Article Integrative network analysis reveals molecular mechanisms of blood pressure regulation.
Academic Article Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease.
Academic Article Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study.
Academic Article Prevalence, Neurohormonal Correlates, and Prognosis of Heart Failure Stages in the Community.
Academic Article Serum ß-Trace Protein and ß2-Microglobulin as Predictors of ESRD, Mortality, and Cardiovascular Disease in Adults With CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study.
Academic Article Relations of circulating GDF-15, soluble ST2, and troponin-I concentrations with vascular function in the community: The Framingham Heart Study.
Academic Article Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community: The Framingham Heart Study.
Academic Article Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.
Academic Article Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium.
Academic Article Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.
Academic Article Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation.
Academic Article Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study.
Academic Article Clinical and Environmental Correlates of Serum BDNF: A Descriptive Study with Plausible Implications for AD Research.
Academic Article Associations of objective physical activity with insulin sensitivity and circulating adipokine profile: the Framingham Heart Study.
Academic Article Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study.
Academic Article Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression.
Academic Article Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.
Academic Article SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.
Academic Article Association of Parental Obesity and Diabetes Mellitus With Circulating Adipokines in Nonobese Nondiabetic Offspring.
Academic Article Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study.
Academic Article Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic Inflammation: The Framingham Heart Study.
Academic Article Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study.
Academic Article Metabolic Predictors of Change in Vascular Function: Prospective Associations From a Community-Based Cohort.
Academic Article Genetic Architecture of the Cardiovascular Risk Proteome.
Academic Article Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries.
Grant Prospective Meta-Analyses of Drug-Gene Interactions: CHARGE GWAS Consortium
Grant Integrating Lipid Genotypes and Phenotypes in iPS Delivered Hepatocytes/Adipocytes
Grant Prospective Meta-Analyses of Drug-Gene Interactions: CHARGE GWAS Consortium
Grant Lipid Biomarkers for Diabetic Heart Disease

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