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Search Results to Vassilis I. Zannis, PhD

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One or more keywords matched the following items that are connected to Zannis, Vassilis

Item TypeName
Concept Lipoprotein Lipase
Concept Lipoproteins
Concept Lipoproteins, HDL
Concept Lipoproteins, LDL
Concept Lipoproteins, VLDL
Concept Receptors, Lipoprotein
Concept Low Density Lipoprotein Receptor-Related Protein-1
Concept Lipoproteins, IDL
Concept High-Density Lipoproteins, Pre-beta
Academic Article Human apolipoprotein E isoprotein subclasses are genetically determined.
Academic Article The carboxyl-terminal hydrophobic residues of apolipoprotein A-I affect its rate of phospholipid binding and its association with high density lipoprotein.
Academic Article Genetic mutations affecting human lipoproteins, their receptors, and their enzymes.
Academic Article Transcriptional regulation of the genes involved in lipoprotein transport. The role of proximal promoters and long-range regulatory elements and factors in apolipoprotein gene regulation.
Academic Article Secretion of lipid-poor nascent human apolipoprotein apoAI, apoCIII, and apoE by cell clones expressing the corresponding genes.
Academic Article Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake.
Academic Article Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and APOA-I mutations on receptor binding.
Academic Article Specificity of lipid incorporation is determined by sequences in the N-terminal 37 of apoB.
Academic Article Analysis of the structure and function relationship of the human apolipoprotein E in vivo, using adenovirus-mediated gene transfer.
Academic Article Old and new players in the lipoprotein system.
Academic Article Structure and function of apolipoprotein A-I and high-density lipoprotein.
Academic Article The N-terminal 17% of apoB binds tightly and irreversibly to emulsions modeling nascent very low density lipoproteins.
Academic Article Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion.
Academic Article Detailed molecular model of apolipoprotein A-I on the surface of high-density lipoproteins and its functional implications.
Academic Article The amino-terminal 1-185 domain of apoE promotes the clearance of lipoprotein remnants in vivo. The carboxy-terminal domain is required for induction of hyperlipidemia in normal and apoE-deficient mice.
Academic Article Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding.
Academic Article The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficient lipid transport.
Academic Article The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo.
Academic Article In vivo studies of HDL assembly and metabolism using adenovirus-mediated transfer of ApoA-I mutants in ApoA-I-deficient mice.
Academic Article Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain.
Academic Article Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice.
Academic Article Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype.
Academic Article Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding.
Academic Article Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain.
Academic Article Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer.
Academic Article Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide.
Academic Article Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-deficient mice.
Academic Article ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression.
Academic Article Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency.
Academic Article Generation of a recombinant apolipoprotein E variant with improved biological functions: hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia.
Academic Article Structure and stability of apolipoprotein a-I in solution and in discoidal high-density lipoprotein probed by double charge ablation and deletion mutation.
Academic Article Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL.
Academic Article Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.
Academic Article The carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of alpha-HDL but not prebeta-HDL particles in vivo.
Academic Article Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.
Academic Article LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.
Academic Article Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.
Academic Article Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.
Academic Article Discrete roles of apoA-I and apoE in the biogenesis of HDL species: lessons learned from gene transfer studies in different mouse models.
Academic Article Biophysical properties of apolipoprotein E4 variants: implications in molecular mechanisms of correction of hypertriglyceridemia.
Academic Article Molecular biology of human apolipoproteins B and E and associated diseases of lipoprotein metabolism.
Academic Article Genetic mutations affecting human lipoprotein metabolism.
Academic Article Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL.
Academic Article Domains of apoE4 required for the biogenesis of apoE-containing HDL.
Academic Article Characterization of the apolipoprotein A-I-C-III gene complex.
Academic Article Apolipoprotein A-I exerts bactericidal activity against Yersinia enterocolitica serotype O:3.
Academic Article Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels.
Academic Article Molecular biology of human apolipoprotein B and related diseases.
Academic Article ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT.
Academic Article Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.
Academic Article Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDL.
Academic Article Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.
Academic Article Synthesis, modification, and flotation properties of rat hepatocyte apolipoproteins.
Academic Article Genetic polymorphism in human apolipoprotein E.
Academic Article Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages.
Academic Article Plasma and hepatic apoE isoproteins of nonhuman primates. Differences in apoE among humans, apes, and New and Old World monkeys.
Academic Article Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification.
Academic Article Isolation and characterization of cDNA clones for human apolipoprotein A-I.
Academic Article Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.
Academic Article Hepatic apo-A-I and apo-E and intestinal apo-A-I are synthesized in precursor isoprotein forms by organ cultures of human fetal tissues.
Academic Article Effect of egg cholesterol and dietary fats on plasma lipids, lipoproteins, and apoproteins of normal women consuming natural diets.
Academic Article ApoE distribution among lipoproteins of rhesus monkeys is modulated by dietary fat and cholesterol.
Academic Article An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis.
Academic Article Independent effects of dietary saturated fat and cholesterol on plasma lipids, lipoproteins, and apolipoprotein E.
Academic Article Identification and DNA sequence of a human apolipoprotein E cDNA clone.
Academic Article Apolipoprotein E.
Academic Article Abnormal apoprotein A-I isoprotein composition in patients with Tangier disease.
Academic Article Characterization of a unique human apolipoprotein E variant associated with type III hyperlipoproteinemia.
Academic Article Isoproteins of human apolipoprotein A-I demonstrated in plasma and intestinal organ culture.
Academic Article Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core.
Academic Article The Effect of Natural LCAT Mutations on the Biogenesis of HDL.
Academic Article Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational.
Academic Article High-density lipoprotein attenuates Th1 and th17 autoimmune responses by modulating dendritic cell maturation and function.
Academic Article Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice.
Academic Article Tissue Uptake Mechanisms Involved in the Clearance of Non-Protein Nanoparticles that Mimic LDL Composition: A Study with Knockout and Transgenic Mice.
Academic Article Role of apolipoproteins, ABCA1 and LCAT in the biogenesis of normal and aberrant high density lipoproteins.
Academic Article HDL-apoA-I induces the expression of angiopoietin like 4 (ANGPTL4) in endothelial cells via a PI3K/AKT/FOXO1 signaling pathway.
Academic Article Lipoprotein metabolism and transendothelial apolipoprotein a-i transport in mice with an endothelium specific knock-out of ATP binding cassette transporter a1
Academic Article Apolipoprotein and lipoprotein synthesis and modifications
Academic Article A3.15 Reconstituted High Density Lipoprotein (rHDL) Modulates T Effector Cell Function in a Murine Model of Rheumatoid Arthritis
Academic Article Abstract: P925 INCREASED BINDING TO TRIGLYCERIDE-RICH LIPOPROTEINS AND DESTABILIZED STRUCTURE OF APOLIPOPROTEIN E4 AND AI FORMS THAT INDUCE HYPERTRIGLYCERIDEMIA
Academic Article A8.28 Reconstituted high density lipoprotein (RHDL) modulates TH1 and TH17 immune responses and pro-inflammatory cytokine production in a murine model of rheumatoid arthritis
Academic Article 1.P.12 Hydrophobic residues between aminoacids 211–229 of apoA-I play an important role in binding to lipids and lipoproteins

Highlights
Search Criteria
  • lipoproteins