Connection

Search Results to Vassilis I. Zannis, PhD

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following properties of Zannis, Vassilis

PropertyValue
Research Expertise & Professional Interests Dr. Zannis is Emeritus Professor of Cardiovascular Medicine at Boston University School of Medicine. The major focus of his research is on the structure and functions of apoA-I and apoE in relation to the biogenesis of HDL, atherosclerosis and Alzheimer's disease. Using adenovirus-mediated gene transfer in apoA-I-deficient mice, we have established that apoA-I mutations inhibit discrete steps in a pathway that leads to the biogenesis and remodeling of HDL. To this point, five discrete categories of apoA-I mutants have been characterized that may affect the interactions of apoA-I with ABCA1 or LCAT or may influence the plasma PLTP activity or may cause various forms of dyslipidemia. Biogenesis of HDL is not a unique property of apoA-I. Using adenovirus-mediated gene transfer of apoE in apoA-I- or ABCA1-deficient mice, we have established that apoE also participates in a novel pathway of biogenesis of apoE-containing HDL particles. This process requires the functions of the ABCA1 lipid transporter and LCAT and it is promoted by substitution of hydrophobic residues in the 261 to 269 region of apoE by Ala. The apoE-containing HDL particles formed in the circulation may have atheroprotective properties. ApoE-containing HDL may also have important biological functions in the brain that confer protection from Alzheimer’s disease.

One or more keywords matched the following items that are connected to Zannis, Vassilis

Item TypeName
Concept Lipoproteins, HDL
Concept Cholesterol, HDL
Academic Article The carboxyl-terminal hydrophobic residues of apolipoprotein A-I affect its rate of phospholipid binding and its association with high density lipoprotein.
Academic Article Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake.
Academic Article Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and APOA-I mutations on receptor binding.
Academic Article Old and new players in the lipoprotein system.
Academic Article Structure and function of apolipoprotein A-I and high-density lipoprotein.
Academic Article Detailed molecular model of apolipoprotein A-I on the surface of high-density lipoproteins and its functional implications.
Academic Article The effects of mutations in helices 4 and 6 of ApoA-I on scavenger receptor class B type I (SR-BI)-mediated cholesterol efflux suggest that formation of a productive complex between reconstituted high density lipoprotein and SR-BI is required for efficient lipid transport.
Academic Article Lipid-free structure and stability of apolipoprotein A-I: probing the central region by mutation.
Academic Article In vivo studies of HDL assembly and metabolism using adenovirus-mediated transfer of ApoA-I mutants in ApoA-I-deficient mice.
Academic Article Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1.
Academic Article Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice.
Academic Article Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding.
Academic Article Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer.
Academic Article Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide.
Academic Article Deletions of helices 2 and 3 of human apoA-I are associated with severe dyslipidemia following adenovirus-mediated gene transfer in apoA-I-deficient mice.
Academic Article Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency.
Academic Article Generation of a recombinant apolipoprotein E variant with improved biological functions: hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia.
Academic Article Structure and stability of apolipoprotein a-I in solution and in discoidal high-density lipoprotein probed by double charge ablation and deletion mutation.
Academic Article Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL.
Academic Article Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.
Academic Article The carboxy-terminal region of apoA-I is required for the ABCA1-dependent formation of alpha-HDL but not prebeta-HDL particles in vivo.
Academic Article Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.
Academic Article LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.
Academic Article Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.
Academic Article Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.
Academic Article Discrete roles of apoA-I and apoE in the biogenesis of HDL species: lessons learned from gene transfer studies in different mouse models.
Academic Article Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice.
Academic Article Genetic mutations affecting human lipoprotein metabolism.
Academic Article Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL.
Academic Article Domains of apoE4 required for the biogenesis of apoE-containing HDL.
Academic Article Characterization of the apolipoprotein A-I-C-III gene complex.
Academic Article Apolipoprotein A-I exerts bactericidal activity against Yersinia enterocolitica serotype O:3.
Academic Article Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels.
Academic Article ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT.
Academic Article Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.
Academic Article Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDL.
Academic Article Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.
Academic Article Synthesis, modification, and flotation properties of rat hepatocyte apolipoproteins.
Academic Article Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages.
Academic Article Isolation and characterization of cDNA clones for human apolipoprotein A-I.
Academic Article Synthesis, intracellular processing, and signal peptide of human apolipoprotein E.
Academic Article Hepatic apo-A-I and apo-E and intestinal apo-A-I are synthesized in precursor isoprotein forms by organ cultures of human fetal tissues.
Academic Article Effect of egg cholesterol and dietary fats on plasma lipids, lipoproteins, and apoproteins of normal women consuming natural diets.
Academic Article An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis.
Academic Article Abnormal apoprotein A-I isoprotein composition in patients with Tangier disease.
Academic Article Isoproteins of human apolipoprotein A-I demonstrated in plasma and intestinal organ culture.
Academic Article Murine mammary-derived cells secrete the N-terminal 41% of human apolipoprotein B on high density lipoprotein-sized lipoproteins containing a triacylglycerol-rich core.
Academic Article The Effect of Natural LCAT Mutations on the Biogenesis of HDL.
Academic Article Effect of apoA-I Mutations in the Capacity of Reconstituted HDL to Promote ABCG1-Mediated Cholesterol Efflux.
Academic Article HDL biogenesis, remodeling, and catabolism.
Academic Article Regulation of HDL genes: transcriptional, posttranscriptional, and posttranslational.
Academic Article High-density lipoprotein attenuates Th1 and th17 autoimmune responses by modulating dendritic cell maturation and function.
Academic Article apoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL.
Academic Article Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice.
Academic Article Tissue Uptake Mechanisms Involved in the Clearance of Non-Protein Nanoparticles that Mimic LDL Composition: A Study with Knockout and Transgenic Mice.
Academic Article HDL-apoA-I induces the expression of angiopoietin like 4 (ANGPTL4) in endothelial cells via a PI3K/AKT/FOXO1 signaling pathway.
Academic Article The role of the C-terminus of human apoA-I on HDL assembly and metabolism
Academic Article Abstract: S3-1 FUNCTIONS OF APOE-CONTAINING HDL IN THE BRAIN
Academic Article MoW15:8 Novel pathway of biogenesis of apoe-containing HDL with the participation of ABCA1 and LCAT: Implications for dyslipidemias and atherogenesis
Academic Article Abstract: 1498 THE ROLE OF APOLIPOPROTEIN E IN TRIGLYCERIDE HOMEOSTASIS AND THE BIOGENESIS OF HDL
Academic Article Synthesis of HDL apolipoproteins by rat hepatocytes
Academic Article 31st Congress of the Federation-of-European-Biochemical-Societies (FEBS)
Academic Article ApoA-I Functions and Synthesis of HDL: Insights from Mouse Models of Human HDL Metabolism
Academic Article Regulation of Genes Involved in the Biogenesis and the Remodeling of HDL
Academic Article Abstract: S3-6 APOA-I HDL BIOGENESIS AND SITES OF REGULATION
Academic Article Abstract: P442 EFFECT OF C-TERMINAL APOE TRUNCATIONS ON BIOGENESIS OF HDL
Academic Article Characterization of APOA-I and HDL metabolism in an endothelial specific ABCA1 deficient mouse model

Highlights
Search Criteria
  • HDL