Search Results to Ronald H. Goldstein, MD

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Research Expertise & Professional Interests Our laboratory is exploring the regulation of the alveolar matrix during the development of early emphysema and fibrosis. The loss of matrix substances results in emphysema whereas the excessive deposition of matrix substances results in pulmonary fibrosis. Employing the techniques of cellular and molecular biology, we are developing methods to modulating the levels of collagen, elastin and other key matrix substances in the alveolar wall. These approaches are studied in wild type and transgenic murine models of emphysema and fibrosis. We have extensive experience in the diagnosis and management of individuals with pulmonary fibrosis. In human studies, our clinical experimental interest involves the use of novel substances to treat idiopathic pulmonary fibrosis (IPF). We participate in several clinical studies to evaluate the efficacy of these agents in the pathogenesis of IPF. Research special interests include: Pulmonary Matrix Biology related to Pulmonary Fibrosis and Emphysema Clinical special interests include: Pulmonary Fibrosis
Self-Described Keywords Pulmonary Fibrosis

One or more keywords matched the following items that are connected to Goldstein, Ronald

Item TypeName
Academic Article Differential expression of elastin and alpha 1(I) collagen mRNA in mice with bleomycin-induced pulmonary fibrosis.
Academic Article Control of type I collagen formation in the lung.
Academic Article Colchicine does not ameliorate bleomycin-induced pulmonary injury in hamsters.
Academic Article Failure of mechanical properties to parallel changes in lung connective tissue composition in bleomycin-induced pulmonary fibrosis in hamsters.
Academic Article Effect of immunomodulators on bleomycin-induced lung injury.
Academic Article The effect of suramin on bleomycin-induced lung injury.
Academic Article Human recombinant interferon-alpha2a and interferon-alphaA/D have different effects on bleomycin-induced lung injury.
Academic Article All-trans-retinoic acid (ATRA) is of no benefit in bleomycin-induced lung injury.
Academic Article Halofuginone does not reduce fibrosis in bleomycin-induced lung injury.
Academic Article Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice.
Academic Article Cellular FLICE-like inhibitory protein deviates myofibroblast fas-induced apoptosis toward proliferation during lung fibrosis.
Academic Article Fibrotic reactions in the lung: the activation of the lung fibroblast.
Academic Article Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin. Lung volumes, volume-pressure relations, carbon monoxide uptake, and arterial blood gas studied.
Academic Article Modification of oxygen toxicity after lung injury by bleomycin in hamsters.
Grant Regulation of Collagen Formation in Pulmonary Fibrosis

Search Criteria
  • Pulmonary Fibrosis