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Search Results to Flora Sam, MD

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Research Expertise & Professional Interests Dr. Sam is the present Director, ad interim, of the Whitaker Cardiovascular Institute. She is an advanced heart failure clinical cardiologist and a physician-scientist. She is a translational researcher and the PI of her NIH funded lab. She is an expert in cardiac myocyte biology and in mechanisms of myocardial remodeling in cardiomyopathy, both in humans and animal models. She is a recognized expert in "heart failure with preserved ejection fraction" (HFpEF) /diastolic heart failure and "heart failure with reduced ejection fraction" (HFrEF)/systolic heart failure and cardiomyopathies. The Sam lab is focused on three major areas of investigation: 1) Pro-inflammatory and pro-fibrotic mechanisms that mediate cardiac remodeling in heart failure, cardiac hypertrophy and hypertension. 2) Investigating the relationship between matrix markers and heart failure in humans with cardiac amyloid and scleroderma. 3) Investigating cross talk between adipocyte-derived factors, myokines and cardiokines in heart failure.

One or more keywords matched the following items that are connected to Sam, Flora

Item TypeName
Concept Adipose Tissue, Brown
Concept Cell Communication
Concept Drug Interactions
Concept Interferon-gamma
Concept Interleukin-10
Concept Intercellular Adhesion Molecule-1
Concept Tissue Inhibitor of Metalloproteinases
Concept Tissue Inhibitor of Metalloproteinase-1
Concept Tissue Inhibitor of Metalloproteinase-2
Concept Adipose Tissue, White
Academic Article ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat.
Academic Article Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload.
Academic Article The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure.
Academic Article Peroxisome proliferator-activated receptor alpha-independent actions of fenofibrate exacerbates left ventricular dilation and fibrosis in chronic pressure overload.
Academic Article Effects of fenofibrate on cardiac remodeling in aldosterone-induced hypertension.
Academic Article Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms.
Academic Article Adiponectin deficiency, diastolic dysfunction, and diastolic heart failure.
Academic Article Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition.
Academic Article Interferon-? ablation exacerbates myocardial hypertrophy in diastolic heart failure.
Academic Article Circulating matrix metalloproteinases and tissue inhibitors of metalloproteinases in cardiac amyloidosis.
Academic Article Monocyte and macrophage contributions to cardiac remodeling.
Academic Article Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue.
Academic Article Cardiac macrophages promote diastolic dysfunction.
Academic Article Heart Failure With Preserved Ejection Fraction and Adipose Tissue: A Story of Two Tales.
Grant Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic Heart Failure
Grant Role of Aldosterone and Adiponectin in Inter-Tissue Communication in Diastolic Heart Failure
Grant Mechanistic underpinnings of increased adipose tissue in HFpEF

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