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Research Expertise & Professional Interests Dr. Lindsay Farrer is a medical geneticist at Boston University Schools of Medicine and Public Health where he is the Boston University Distinguished Professor of Genetics, Chief of Biomedical Genetics, and a Professor of Medicine, Neurology, Ophthalmology, Epidemiology, and Biostatistics. Dr. Farrer is a graduate of the University of North Carolina in Chapel Hill, received his Ph.D. from the Indiana University School of Medicine, and gained additional training in genetic epidemiology at Yale University. He holds adjunct faculty positions at Harvard Medical School, Massachusetts General Hospital, and the Veterans Administration Medical Center in Bedford, Massachusetts. He is a Founding Fellow of the American College of Medical Genetics. Dr. Farrer teaches several courses in human genetics and addiction science at Boston University, directs the BU Transformative Training Program in Addiction Science (TTPAS) that features transdisciplinary training for students enrolled in PhD programs across the Medical and Charles River campuses, directs Boston University’s Molecular Genetics Core Facility which offers DNA genotyping and sequencing services to investigators at Boston University and elsewhere, and provides genetic counseling and testing to patients with a variety of inherited conditions. Dr. Farrer’s research has lead to more than 450 publications on genetic risk factors for several familial neurodegenerative and other chronic diseases. In collaboration with other laboratories worldwide, his group has localized genes causing a variety of rare and common disorders, most notably Alzheimer disease (AD), substance use disorders (SUDs), age-related macular degeneration (AMD), Wilson disease, Machado-Joseph disease, Waardenburg syndrome, hypertension, sensorineural deafness, and osteoarthritis. His group identified a functional genetic variant in the complement factor H gene which accounts for more than 30% of the attributable risk for AMD, the leading cause of progressive vision loss and blindness in the elderly. In collaboration with other researchers, Dr. Farrer is conducting genome wide association studies (GWAS) and whole genome/exome sequencing studies for several disorders including AD, SUDs (cocaine, opiates, nicotine, alcohol and cannabis), and AMD. Dr. Farrer’s team is also developing methods for locating genes that influence the natural history of complex diseases and pharmacogenetic response. Under Dr. Farrer’s leadership, the MIRAGE Project, a multi-center study of AD funded since 1991 by the National Institute on Aging, has made several important contributions to our understanding of the interactions between genetic and environmental factors for the disorder. This study has a particular emphasis on the genetics of AD in African Americans. MIRAGE was the first study to demonstrate that genetic factors have a major role in the development of AD and that APOE e4 is more weakly associated with disease in men and persons older than 75 years. Dr. Farrer co-directed the international effort which demonstrated that SORL1 is genetically and functionally associated with AD, thus implicating intracellular protein trafficking as integral pathway in AD. His laboratory conducted genome wide association studies (GWAS) for AD in several populations including African Americans and an inbred Israeli-Arab community, and identified rare AD causal mutations in the AKAP9 gene which are specific to African Americans. Dr. Farrer serves on the Executive Committee of the national Alzheimer Disease Genetics Consortium and co-directs the data analysis effort for this large NIH-funded project. He is also a Principal Investigator of the national Alzheimer Disease Sequencing Project and a study to identify AD risk and protective variants in Koreans.

One or more keywords matched the following items that are connected to Farrer, Lindsay

Item TypeName
Concept Asthma
Concept Cross-Sectional Studies
Concept Evaluation Studies as Topic
Concept Feasibility Studies
Concept Follow-Up Studies
Concept Longitudinal Studies
Concept Prospective Studies
Concept Protein Processing, Post-Translational
Concept Retrospective Studies
Concept Cohort Studies
Concept Epidemiologic Studies
Concept Case-Control Studies
Concept Genetic Association Studies
Academic Article Apolipoprotein E genotype in patients with Alzheimer's disease: implications for the risk of dementia among relatives.
Academic Article 46,XY/47,XYY male with the fragile X syndrome: cytogenetic and molecular studies.
Academic Article Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.
Academic Article Evidence for linkage between essential hypertension and a putative locus on human chromosome 17.
Academic Article Reliability of information collected by proxy in family studies of Alzheimer's disease.
Academic Article Association between apolipoprotein E genotype and Alzheimer disease in African American subjects.
Academic Article Depression as a risk factor for Alzheimer disease: the MIRAGE Study.
Academic Article Search for genetic factors predisposing to atherogenic dyslipidemia.
Academic Article Genome-wide screen for heavy alcohol consumption.
Academic Article Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Academic Article Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study.
Academic Article Postmenopausal hormone therapy and Alzheimer's disease risk: interaction with age.
Academic Article Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia.
Academic Article Polymorphisms in the promoter region of catalase gene and essential hypertension.
Academic Article Multifactor-dimensionality reduction versus family-based association tests in detecting susceptibility loci in discordant sib-pair studies.
Academic Article Complement factor H polymorphism and age-related macular degeneration.
Academic Article Association of asthma with a functional promoter polymorphism in the IL16 gene.
Academic Article Association studies between the plasmin genes and late-onset Alzheimer's disease.
Academic Article Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus.
Academic Article Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study.
Academic Article Association of polymorphisms in the Angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community.
Academic Article Genetic association between endothelial nitric oxide synthase and Alzheimer disease.
Academic Article Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B.
Academic Article The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort.
Academic Article Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.
Academic Article Collection of clinical and epidemiological data for linkage studies.
Academic Article Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity.
Academic Article Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals.
Academic Article Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
Academic Article Sources of unreliability in the diagnosis of substance dependence.
Academic Article Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.
Academic Article Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.
Academic Article Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.
Academic Article Disclosure of APOE genotype for risk of Alzheimer's disease.
Academic Article Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach.
Academic Article Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.
Academic Article Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.
Academic Article Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study.
Academic Article Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
Academic Article Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease.
Academic Article Healthy aging and preclinical dementia: the United States-Israel Longitudinal Database project.
Academic Article Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Academic Article Genome-wide analysis of genetic loci associated with Alzheimer disease.
Academic Article Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
Academic Article Mild cognitive impairment is associated with mild parkinsonian signs in a door-to-door study.
Academic Article Predictive testing for Huntington's disease with use of a linked DNA marker.
Academic Article Empirically derived subtypes of opioid use and related behaviors.
Academic Article A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression.
Academic Article Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.
Academic Article No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samples.
Academic Article Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Academic Article Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.
Academic Article Magnetic resonance imaging-measured atrophy and its relationship to cognitive functioning in vascular dementia and Alzheimer's disease patients.
Academic Article A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
Academic Article Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration.
Academic Article A comprehensive genetic association study of Alzheimer disease in African Americans.
Academic Article Collection of clinical and epidemiological data for genetic linkage and association studies.
Academic Article Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors.
Academic Article Genome-wide association study of Alzheimer's disease.
Academic Article Association of COL25A1 with comorbid antisocial personality disorder and substance dependence.
Academic Article Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.
Academic Article Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample.
Academic Article d-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.
Academic Article Seven new loci associated with age-related macular degeneration.
Academic Article Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype.
Academic Article GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
Academic Article Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans.
Academic Article Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
Academic Article Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.
Academic Article Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).
Academic Article Determining the genetic component of a disease
Academic Article Reliability of self-reported age at onset of major depression.
Academic Article Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
Academic Article Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence.
Academic Article Genome-wide association study of the rate of cognitive decline in Alzheimer''s disease.
Academic Article Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.
Academic Article Gene-wide analysis detects two new susceptibility genes for Alzheimer''s disease.
Academic Article Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer''s disease.
Academic Article Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
Academic Article Follow-up of loci from the International Genomics of Alzheimer''s Disease Project identifies TRIP4 as a novel susceptibility gene.
Academic Article Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.
Academic Article Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Academic Article Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes.
Academic Article Genome-wide association meta-analysis of neuropathologic features of Alzheimer''s disease and related dementias.
Academic Article Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
Academic Article Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.
Academic Article ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
Academic Article PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.
Academic Article Global and local ancestry in African-Americans: Implications for Alzheimer''s disease risk.
Academic Article Critical evaluation of transcription factor Atf2 as a candidate modulator of alcohol preference in mouse and human populations.
Academic Article Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.
Academic Article Further analyses support the association between light eye color and alcohol dependence.
Academic Article Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions.
Academic Article Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.
Academic Article Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.
Academic Article Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.
Academic Article A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer''s Disease Brains.
Academic Article Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
Academic Article Largest GWAS of PTSD (N=20?070) yields genetic overlap with schizophrenia and sex differences in heritability.
Grant Genetic Epidemiological Studies of Alzheimer Disease
Grant Family Based Studies of Gene-Environment Interactions in Alzheimer’s Disease
Academic Article Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer''s disease.
Academic Article Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport.
Academic Article Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior.
Academic Article Caspase-8, association with Alzheimer''s Disease and functional analysis of rare variants.
Academic Article Genome-wide association study identifies a novel locus for cannabis dependence.
Academic Article Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer''s Disease Sequencing Project.
Academic Article Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Academic Article FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-p Interactions.
Academic Article One for all and all for One: Improving replication of genetic studies through network diffusion.
Academic Article Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response.
Academic Article HIGH-RESOLUTION IMPUTATION IN GENOME-WIDE ASSOCIATION STUDIES OF LATE-ONSET ALZHEIMER'S DISEASE IDENTIFIES NOVEL RARE VARIANT ASSOCIATIONS
Academic Article LINKAGE AND ASSOCIATION STUDIES OF CANNABIS DEPENDENCE SUGGEST NRG1 AS A RISK LOCUS
Academic Article A review of published genetic studies using ADNI multimodality quantitative phenotypes: MRI, PET, fluid biomarkers, cognition and clinical status
Academic Article Structural, functional and molecular imaging as intermediate phenotypes for studies of candidate genes, pathways and GWAS in Alzheimer's disease
Academic Article GENOMEWIDE STUDIES OF ALCOHOL DEPENDENCE
Academic Article Using CSF biomarkers to replicate genetic associations in Alzheimer's disease.
Academic Article Genetic linkage studies of Alzheimer's disease in Israeli arabs
Academic Article Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer''s disease.
Academic Article Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer''s disease.
Academic Article Ancestral origin of ApoE e4 Alzheimer disease risk in Puerto Rican and African American populations.
Academic Article A rare missense variant of CASP7 is associated with familial late-onset Alzheimer''s disease.
Academic Article Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article The Utah Protocol for Postmortem Eye Phenotyping and Molecular Biochemical Analysis.
Academic Article Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence.
Academic Article CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.
Academic Article Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes.
Academic Article International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
Academic Article Exceptionally low likelihood of Alzheimer''s dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Academic Article Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Grant Genetic Studies of Alzheimer Disease in Koreans
Grant Genomic and Biological Studies of APOE e2 in Alzheimer's Disease

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