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Research Expertise & Professional Interests Dr. Lindsay Farrer is a medical geneticist at Boston University Schools of Medicine and Public Health where he is the Boston University Distinguished Professor of Genetics, Chief of Biomedical Genetics, and a Professor of Medicine, Neurology, Ophthalmology, Epidemiology, and Biostatistics. Dr. Farrer is a graduate of the University of North Carolina in Chapel Hill, received his Ph.D. from the Indiana University School of Medicine, and gained additional training in genetic epidemiology at Yale University. He holds adjunct faculty positions at Harvard Medical School, Massachusetts General Hospital, and the Veterans Administration Medical Center in Bedford, Massachusetts. He is a Founding Fellow of the American College of Medical Genetics. Dr. Farrer teaches several courses in human genetics and addiction science at Boston University, directs the BU Transformative Training Program in Addiction Science (TTPAS) that features transdisciplinary training for students enrolled in PhD programs across the Medical and Charles River campuses, directs Boston University’s Molecular Genetics Core Facility which offers DNA genotyping and sequencing services to investigators at Boston University and elsewhere, and provides genetic counseling and testing to patients with a variety of inherited conditions. Dr. Farrer’s research has lead to more than 450 publications on genetic risk factors for several familial neurodegenerative and other chronic diseases. In collaboration with other laboratories worldwide, his group has localized genes causing a variety of rare and common disorders, most notably Alzheimer disease (AD), substance use disorders (SUDs), age-related macular degeneration (AMD), Wilson disease, Machado-Joseph disease, Waardenburg syndrome, hypertension, sensorineural deafness, and osteoarthritis. His group identified a functional genetic variant in the complement factor H gene which accounts for more than 30% of the attributable risk for AMD, the leading cause of progressive vision loss and blindness in the elderly. In collaboration with other researchers, Dr. Farrer is conducting genome wide association studies (GWAS) and whole genome/exome sequencing studies for several disorders including AD, SUDs (cocaine, opiates, nicotine, alcohol and cannabis), and AMD. Dr. Farrer’s team is also developing methods for locating genes that influence the natural history of complex diseases and pharmacogenetic response. Under Dr. Farrer’s leadership, the MIRAGE Project, a multi-center study of AD funded since 1991 by the National Institute on Aging, has made several important contributions to our understanding of the interactions between genetic and environmental factors for the disorder. This study has a particular emphasis on the genetics of AD in African Americans. MIRAGE was the first study to demonstrate that genetic factors have a major role in the development of AD and that APOE e4 is more weakly associated with disease in men and persons older than 75 years. Dr. Farrer co-directed the international effort which demonstrated that SORL1 is genetically and functionally associated with AD, thus implicating intracellular protein trafficking as integral pathway in AD. His laboratory conducted genome wide association studies (GWAS) for AD in several populations including African Americans and an inbred Israeli-Arab community, and identified rare AD causal mutations in the AKAP9 gene which are specific to African Americans. Dr. Farrer serves on the Executive Committee of the national Alzheimer Disease Genetics Consortium and co-directs the data analysis effort for this large NIH-funded project. He is also a Principal Investigator of the national Alzheimer Disease Sequencing Project and a study to identify AD risk and protective variants in Koreans.
Self-Described Keywords Alzheimer disease

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Concept Alleles
Concept Alzheimer Disease
Concept Amino Acid Sequence
Concept Amyotrophic Lateral Sclerosis
Concept Anemia, Sickle Cell
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Base Sequence
Concept Behavioral Symptoms
Concept Binding Sites
Concept Brain Diseases
Concept Cardiovascular Diseases
Concept Charcot-Marie-Tooth Disease
Concept Computer Simulation
Concept Coronary Artery Disease
Concept Cross-Sectional Studies
Concept Data Interpretation, Statistical
Concept Disease
Concept Disease Models, Animal
Concept Disease Susceptibility
Concept Diseases in Twins
Concept DNA, Satellite
Concept Drug Synergism
Concept Educational Status
Concept Endocrine System Diseases
Concept Epistasis, Genetic
Concept Evaluation Studies as Topic
Concept Factor Analysis, Statistical
Concept Feasibility Studies
Concept Follow-Up Studies
Concept Fragile X Syndrome
Concept Genes
Concept Genes, Dominant
Concept Genes, Homeobox
Concept Genes, Recessive
Concept Multigene Family
Concept Health Status
Concept Health Surveys
Concept Heat-Shock Proteins
Concept Hemoglobin, Sickle
Concept Hirschsprung Disease
Concept Huntington Disease
Concept Information Systems
Concept Length of Stay
Concept Lod Score
Concept Longitudinal Studies
Concept Major Histocompatibility Complex
Concept Marijuana Smoking
Concept Mass Screening
Concept Mental Status Schedule
Concept Mice, Inbred Strains
Concept Mice, Mutant Strains
Concept Molecular Sequence Data
Concept Neonatal Abstinence Syndrome
Concept S100 Proteins
Concept Synaptic Transmission
Concept Organ Specificity
Concept Organ Size
Concept Parkinson Disease
Concept Population Surveillance
Concept Prospective Studies
Concept Psychiatric Status Rating Scales
Concept Psychoses, Substance-Induced
Concept Receptors, Cell Surface
Concept Receptors, Serotonin
Concept Reference Standards
Concept Regulatory Sequences, Nucleic Acid
Concept Repetitive Sequences, Nucleic Acid
Concept Retrospective Studies
Concept Saliva
Concept Schizophrenia
Concept Schizophrenic Psychology
Concept Sclerosis
Concept Scotland
Concept Self-Help Groups
Concept Sensitivity and Specificity
Concept Serine
Concept Severity of Illness Index
Concept Sexual Behavior
Concept Sex Characteristics
Concept Sex Chromosome Aberrations
Concept Sex Factors
Concept Skin Neoplasms
Concept Skinfold Thickness
Concept Sleep
Concept Smoking
Concept Social Environment
Concept Socioeconomic Factors
Concept Software
Concept Solubility
Concept Spain
Concept Species Specificity
Concept Spinal Puncture
Concept Spinocerebellar Degenerations
Concept Statistics as Topic
Concept Stem Cells
Concept Street Drugs
Concept Stress Disorders, Post-Traumatic
Concept Stress, Psychological
Concept Structure-Activity Relationship
Concept Substance Withdrawal Syndrome
Concept Suicide
Concept Suicide, Attempted
Concept Sulfonylurea Compounds
Concept Sweden
Concept Switzerland
Concept Sympathetic Nervous System
Concept United States
Concept Waardenburg Syndrome
Concept Blotting, Southern
Concept Models, Statistical
Concept Sulfotransferases
Concept Deoxyribonucleases, Type II Site-Specific
Concept Cohort Studies
Concept Molecular Structure
Concept Signal Transduction
Concept Trauma Severity Indices
Concept Gene Library
Concept Substance Abuse, Intravenous
Concept Genome, Human
Concept Tomography, Emission-Computed, Single-Photon
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Concept Chi-Square Distribution
Concept Least-Squares Analysis
Concept Survival Analysis
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Concept Sequence Homology, Amino Acid
Concept Sequence Analysis, DNA
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Concept Protein Structure, Secondary
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Concept Sex Distribution
Concept Machado-Joseph Disease
Concept Genes, Reporter
Concept Oxidative Stress
Concept Sample Size
Concept Disease Progression
Concept Patient Selection
Concept Statistics, Nonparametric
Concept Sepsis
Concept HSP70 Heat-Shock Proteins
Concept Staurosporine
Concept Neurodegenerative Diseases
Concept Amino Acid Substitution
Concept Substance-Related Disorders
Concept Calcium Signaling
Concept Genetic Predisposition to Disease
Concept Catalytic Domain
Concept Alcohol-Induced Disorders, Nervous System
Concept Alcohol Withdrawal Seizures
Concept Oligonucleotide Array Sequence Analysis
Concept Stroke
Concept Genes, myb
Concept Polymorphism, Single Nucleotide
Concept RNA Splice Sites
Concept Electrophoretic Mobility Shift Assay
Concept Metabolic Syndrome X
Concept Tumor Suppressor Proteins
Concept Amino Acid Transport Systems, Basic
Concept Symporters
Concept Organic Anion Transporters, Sodium-Dependent
Concept Genetic Diseases, Inborn
Concept RNA, Small Interfering
Concept Siblings
Concept Diagnostic and Statistical Manual of Mental Disorders
Concept Pluripotent Stem Cells
Concept Semaphorins
Concept Semaphorin-3A
Concept Quantitative Trait Loci
Concept DNA Repeat Expansion
Concept Receptor, Serotonin, 5-HT2B
Concept Unsafe Sex
Concept Intracellular Signaling Peptides and Proteins
Concept Adaptor Proteins, Signal Transducing
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Concept Systems Biology
Concept Serotonin Plasma Membrane Transport Proteins
Concept STAT6 Transcription Factor
Concept Smad3 Protein
Concept Smad6 Protein
Concept Nitric Oxide Synthase Type I
Concept Nitric Oxide Synthase Type III
Concept CARD Signaling Adaptor Proteins
Concept Amyloid Precursor Protein Secretases
Concept Adult Survivors of Child Abuse
Concept Genome-Wide Association Study
Concept Protein Stability
Concept Genetic Loci
Concept Sirtuin 1
Concept Genetic Association Studies
Concept Endosomal Sorting Complexes Required for Transport
Concept Nuclear Receptor Subfamily 1, Group F, Member 1
Concept Mice, 129 Strain
Concept Sorting Nexins
Concept Genetic Pleiotropy
Concept Molecular Sequence Annotation
Concept High-Throughput Nucleotide Sequencing
Concept Suicidal Ideation
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Concept Support Vector Machine
Concept Wnt Signaling Pathway
Concept Molecular Docking Simulation
Concept Sialic Acid Binding Ig-like Lectin 3
Concept Sulfonylurea Receptors
Academic Article Statement on use of apolipoprotein E testing for Alzheimer disease. American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer disease.
Academic Article Apolipoprotein E genotype in patients with Alzheimer's disease: implications for the risk of dementia among relatives.
Academic Article Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease.
Academic Article Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes.
Academic Article [Mapping the gene for palmoplantar hyperkeratosis (thylosis) to chromosome 17 in the 17q12-q24 region].
Academic Article Correlation between CAG repeat length and clinical features in Machado-Joseph disease.
Academic Article A contiguous linkage map of chromosome 13q with 39 distinct loci separated on average by 5.1 centimorgans.
Academic Article Rate of progression of Alzheimer's disease is associated with genetic risk.
Academic Article Machado Joseph disease maps to the same region of chromosome 14 as the spinocerebellar ataxia type 3 locus.
Academic Article A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21.
Academic Article Locus heterogeneity for Waardenburg syndrome is predictive of clinical subtypes.
Academic Article 46,XY/47,XYY male with the fragile X syndrome: cytogenetic and molecular studies.
Academic Article Polymorphic microsatellites and Wilson disease (WD).
Academic Article A 4.5-megabase yeast artificial chromosome contig from human chromosome 13q14.3 ordering 9 polymorphic microsatellites (22 sequence-tagged sites) tightly linked to the Wilson disease locus.
Academic Article Refining the position of Wilson disease by linkage disequilibrium with polymorphic microsatellites.
Academic Article Estimating the probability for major gene Alzheimer disease.
Academic Article Susceptibility genes for familial Alzheimer's disease on chromosomes 19 and 21: a reality check.
Academic Article The normal Huntington disease (HD) allele, or a closely linked gene, influences age at onset of HD.
Academic Article Genetic transmission of Alzheimer's disease among families in a Dutch population based study.
Academic Article Linkage of congenital, recessive deafness (DFNB4) to chromosome 7q31 and evidence for genetic heterogeneity in the Middle Eastern Druze population.
Academic Article Linkage of congenital recessive deafness (gene DFNB10) to chromosome 21q22.3.
Academic Article A familial factor independent of CAG repeat length influences age at onset of Machado-Joseph disease.
Academic Article Presenilin polymorphisms in Alzheimer's disease.
Academic Article No genetic effect of alpha1-antichymotrypsin in Alzheimer disease.
Academic Article Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old?
Academic Article Linkage of polymorphic congenital cataract to the gamma-crystallin gene locus on human chromosome 2q33-35.
Academic Article Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4.
Academic Article A novel mutation in the MITF gene causes Waardenburg syndrome type 2.
Academic Article Linkage disequilibrium analysis in Machado-Joseph disease patients of different ethnic origins.
Academic Article No association between alpha 1-antichymotrypsin and familial Alzheimer's disease.
Academic Article The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective.
Academic Article No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease.
Academic Article Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease.
Academic Article Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
Academic Article Novel ATP7B mutations causing Wilson disease in several Israeli ethnic groups.
Academic Article Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease.
Academic Article Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE.
Academic Article Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.
Academic Article Smoking and risk of Alzheimer's disease. MIRAGE Study Group.
Academic Article Association between bleomycin hydrolase and Alzheimer's disease in caucasians.
Academic Article An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease.
Academic Article Alpha-2 macroglobulin gene in early- and late-onset Alzheimer disease.
Academic Article Detecting linkage for a complex disease using simulated extended pedigrees.
Academic Article Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.
Academic Article Correlation between Waardenburg syndrome phenotype and genotype in a population of individuals with identified PAX3 mutations.
Academic Article Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q.
Academic Article A family history study of male sexual orientation using three independent samples.
Academic Article Evidence for linkage between essential hypertension and a putative locus on human chromosome 17.
Academic Article Identification of a polymorphic glutamic acid stretch in the alpha2B-adrenergic receptor and lack of linkage with essential hypertension.
Academic Article No association between the HLA-A2 allele and Alzheimer disease.
Academic Article Familial risk for Alzheimer disease in ethnic minorities: nondiscriminating genes.
Academic Article Power of concordant versus discordant sib pairs at different penetrance levels.
Academic Article Stratification techniques to explore genotype environment interactions.
Academic Article Association between angiotensin-converting enzyme and Alzheimer disease.
Academic Article Intercontinental epidemiology of Alzheimer disease: a global approach to bad gene hunting.
Academic Article Highly polymorphic short tandem repeat analyses clarify complex molecular test results.
Academic Article Genetic predisposition to stroke in relatives of hypertensives.
Academic Article No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease.
Academic Article Head injury and the risk of AD in the MIRAGE study.
Academic Article Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Academic Article Reliability of information collected by proxy in family studies of Alzheimer's disease.
Academic Article Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition.
Academic Article The angiotensin-converting enzyme gene as a possible risk or protective factor in Alzheimer's disease.
Academic Article Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.
Academic Article Maternal component in the familial aggregation of hypertension.
Academic Article Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.
Academic Article The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14.
Academic Article Waardenburg syndrome (WS) type I is caused by defects at multiple loci, one of which is near ALPP on chromosome 2: first report of the WS consortium.
Academic Article Risk of dementia among white and African American relatives of patients with Alzheimer disease.
Academic Article Association between apolipoprotein E genotype and Alzheimer disease in African American subjects.
Academic Article Genetic and environmental risk factors for Alzheimer's disease in Israeli Arabs.
Academic Article Regulatory region variability in the human presenilin-2 (PSEN2) gene: potential contribution to the gene activity and risk for AD.
Academic Article Monozygotic twins concordant for late-onset probable Alzheimer disease with suspected Alzheimer disease in four sibs.
Academic Article Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community.
Academic Article Comparison of Alzheimer's disease risk factors in white and African American families.
Academic Article Genetic variants of WNK4 in whites and African Americans with hypertension.
Academic Article Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer disease.
Academic Article Differences between African Americans and Whites in their attitudes toward genetic testing for Alzheimer's disease.
Academic Article Depression as a risk factor for Alzheimer disease: the MIRAGE Study.
Academic Article Genetic and environmental epidemiology of Alzheimer's disease in arabs residing in Israel.
Academic Article The genetics of adult-onset neuropsychiatric disease: complexities and conundra?
Academic Article Polymorphisms near a chromosome 6q QTL area are associated with modulation of fetal hemoglobin levels in sickle cell anemia.
Academic Article The Machado-Joseph disease locus is different from the spinocerebellar ataxia locus (SCA1).
Academic Article Empirically derived phenotypic subgroups - qualitative and quantitative trait analyses.
Academic Article Search for genetic factors predisposing to atherogenic dyslipidemia.
Academic Article Genome-wide screen for heavy alcohol consumption.
Academic Article Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Academic Article Segregation analysis of total nevus density and estimation of lifetime risk and average onset age of melanoma.
Academic Article Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study.
Academic Article Who seeks genetic susceptibility testing for Alzheimer's disease? Findings from a multisite, randomized clinical trial.
Academic Article Analysis of the glucocerebrosidase gene in Parkinson's disease.
Academic Article Postmenopausal hormone therapy and Alzheimer's disease risk: interaction with age.
Academic Article Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia.
Academic Article Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project).
Academic Article Polymorphisms in the promoter region of catalase gene and essential hypertension.
Academic Article Hemolysis-associated priapism in sickle cell disease.
Academic Article Estimation of morbid risk and age at onset with missing information.
Academic Article Patterns of inheritance of the symptoms of Huntington's disease suggestive of an effect of genomic imprinting.
Academic Article Multifactor-dimensionality reduction versus family-based association tests in detecting susceptibility loci in discordant sib-pair studies.
Academic Article Whole-genome variance components linkage analysis using single-nucleotide polymorphisms versus microsatellites on quantitative traits of derived phenotypes from factor analysis of electroencephalogram waves.
Academic Article Genome-wide linkage analysis for alcohol dependence: a comparison between single-nucleotide polymorphism and microsatellite marker assays.
Academic Article Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study.
Academic Article Complement factor H polymorphism and age-related macular degeneration.
Academic Article Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis.
Academic Article Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP).
Academic Article Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA).
Academic Article Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia.
Academic Article APOE, vascular pathology, and the AD brain.
Academic Article Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia.
Academic Article An alpha satellite DNA polymorphism specific for the centromeric region of chromosome 13.
Academic Article Polymorphisms in the PON gene cluster are associated with Alzheimer disease.
Academic Article Association of asthma with a functional promoter polymorphism in the IL16 gene.
Academic Article The serotonin receptor subtype 2 locus HTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14.
Academic Article Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs.
Academic Article Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans.
Academic Article Association studies between the plasmin genes and late-onset Alzheimer's disease.
Academic Article Predictive testing for Wilson's disease using tightly linked and flanking DNA markers.
Academic Article Predictors of subjective memory complaint in cognitively normal relatives of patients with Alzheimer's disease.
Academic Article Education effects on cognitive function in a healthy aged Arab population.
Academic Article Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus.
Academic Article Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.
Academic Article Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study.
Academic Article Fetal hemoglobin in sickle cell anemia: genetic determinants of response to hydroxyurea.
Academic Article Genomewide linkage scan for opioid dependence and related traits.
Academic Article Association of polymorphisms in the Angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community.
Academic Article Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF-beta/BMP pathway.
Academic Article Genetic association between endothelial nitric oxide synthase and Alzheimer disease.
Academic Article Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia.
Academic Article Serum heat shock protein 70 level as a biomarker of exceptional longevity.
Academic Article Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein receptor 1B.
Academic Article The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
Academic Article Segregation analysis reveals evidence of a major gene for Alzheimer disease.
Academic Article The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort.
Academic Article Association of decreased paternal age and late-onset Alzheimer's disease. An example of genetic imprinting?
Academic Article Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future.
Academic Article The validity of cocaine dependence subtypes.
Academic Article Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA).
Academic Article A network model to predict the risk of death in sickle cell disease.
Academic Article Variation and heritability of Hb F and F-cells among beta-thalassemia heterozygotes in Hong Kong.
Academic Article Heritability of magnetic resonance imaging (MRI) traits in Alzheimer disease cases and their siblings in the MIRAGE study.
Academic Article Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects.
Academic Article Beta-globin gene cluster polymorphisms are strongly associated with severity of HbE/beta(0)-thalassemia.
Academic Article Association between SORL1 and Alzheimer's disease in a genome-wide study.
Academic Article Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.
Academic Article Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience.
Academic Article Collection of clinical and epidemiological data for linkage studies.
Academic Article Substance dependence low-density whole genome association study in two distinct American populations.
Academic Article Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity.
Academic Article Estimation of familial risk in Alzheimer's disease.
Academic Article Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals.
Academic Article Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10.
Academic Article Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.
Academic Article Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.
Academic Article Association of variants in MANEA with cocaine-related behaviors.
Academic Article Performance of random forest when SNPs are in linkage disequilibrium.
Academic Article Sources of unreliability in the diagnosis of substance dependence.
Academic Article Correlates of co-occurring ADHD in drug-dependent subjects: prevalence and features of substance dependence and psychiatric disorders.
Academic Article Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer's type in an elderly Arab population in Wadi Ara, Israel.
Academic Article BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies.
Academic Article Wilson's disease in Israel: a genetic and epidemiological study.
Academic Article Magnetic resonance imaging traits in siblings discordant for Alzheimer disease.
Academic Article Essential tremor might be less frequent than Parkinson's disease in North Israel Arab villages.
Academic Article Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.
Academic Article Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.
Academic Article Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.
Academic Article Statin use and the risk of Alzheimer's disease: the MIRAGE study.
Academic Article The Nevada Vital Aging Initiative: a private-public partnership to study early predictors of dementia.
Academic Article Disclosure of APOE genotype for risk of Alzheimer's disease.
Academic Article Subtypes of major depression in substance dependence.
Academic Article Convergence of linkage, gene expression and association data demonstrates the influence of the RAR-related orphan receptor alpha (RORA) gene on neovascular AMD: a systems biology based approach.
Academic Article Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP).
Academic Article Homozygote for Huntington disease.
Academic Article Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.
Academic Article Hypertension increases the probability of Alzheimer's disease and of mild cognitive impairment in an Arab community in northern Israel.
Academic Article Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.
Academic Article Education attenuates the effect of medial temporal lobe atrophy on cognitive function in Alzheimer's disease: the MIRAGE study.
Academic Article Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders.
Academic Article Molecular genetics of familial Alzheimer's disease.
Academic Article Familial Alzheimer's disease: progress and problems.
Academic Article Adolescent cannabis use increases risk for cocaine-induced paranoia.
Academic Article Molecular genetics of familial Alzheimer's disease.
Academic Article Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study.
Academic Article Confirmation and generalization of an alcohol-dependence locus on chromosome 10q.
Academic Article Genetic modifiers of Hb E/beta0 thalassemia identified by a two-stage genome-wide association study.
Academic Article Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
Academic Article Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder.
Academic Article Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.
Academic Article Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease.
Academic Article Healthy aging and preclinical dementia: the United States-Israel Longitudinal Database project.
Academic Article Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Academic Article Agitated depression in substance dependence.
Academic Article SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.
Academic Article Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.
Academic Article Genome-wide analysis of genetic loci associated with Alzheimer disease.
Academic Article Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
Academic Article Mild cognitive impairment is associated with mild parkinsonian signs in a door-to-door study.
Academic Article Localization and linkage of three polymorphic DNA sequences on human chromosome 20.
Academic Article Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.
Academic Article Identification of novel candidate genes for Alzheimer's disease by autozygosity mapping using genome wide SNP data.
Academic Article An efficient strategy for gene mapping using multipoint linkage analysis: exclusion of the multiple endocrine neoplasia 2A (MEN2A) locus from chromosome 13.
Academic Article A new human RFLP identified by 7D2 places D13S10 proximal to esterase D.
Academic Article Linkage analysis of multiple endocrine neoplasia type 2A (MEN-2A) and three DNA markers on chromosome 20: evidence against synteny.
Academic Article Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage.
Academic Article One large kindred excludes a locus for multiple endocrine neoplasia type 2A from about 25% of the human autosomal genetic map.
Academic Article Predictive testing for Huntington's disease with use of a linked DNA marker.
Academic Article Empirically derived subtypes of opioid use and related behaviors.
Academic Article Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.
Academic Article Considerations in using linkage analysis as a presymptomatic test for Huntington's disease.
Academic Article A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression.
Academic Article 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder.
Academic Article Ancestry of African Americans with sickle cell disease.
Academic Article Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.
Academic Article No association between ADCYAP1R1 and post-traumatic stress disorder in two independent samples.
Academic Article GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.
Academic Article A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women.
Academic Article Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology.
Academic Article Childhood adversity increases risk for nicotine dependence and interacts with a5 nicotinic acetylcholine receptor genotype specifically in males.
Academic Article Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Academic Article Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.
Academic Article Genetics and genomics of late-onset Alzheimer's disease and its endophenotypes.
Academic Article Magnetic resonance imaging-measured atrophy and its relationship to cognitive functioning in vascular dementia and Alzheimer's disease patients.
Academic Article Hamilton et al. Respond to "Consolidating Data Harmonization"
Academic Article The PhenX Toolkit: get the most from your measures.
Academic Article A genomewide linkage scan of cocaine dependence and major depressive episode in two populations.
Academic Article A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
Academic Article Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration.
Academic Article A comprehensive genetic association study of Alzheimer disease in African Americans.
Academic Article ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.
Academic Article Variation in OPRM1 and risk of suicidal behavior in drug-dependent individuals.
Academic Article High prevalence of mild cognitive impairment and Alzheimer's disease in arabic villages in northern Israel: impact of gender and education.
Academic Article Collection of clinical and epidemiological data for genetic linkage and association studies.
Academic Article Eight closely linked loci place the Wilson disease locus within 13q14-q21.
Academic Article Autosomal linkage scan for loci predisposing to comorbid dependence on multiple substances.
Academic Article Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.
Academic Article Identification of Alzheimer disease-associated variants in genes that regulate retromer function.
Academic Article Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.
Academic Article Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: a replication study.
Academic Article Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors.
Academic Article Genome-wide association study of Alzheimer's disease.
Academic Article Association of COL25A1 with comorbid antisocial personality disorder and substance dependence.
Academic Article Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.
Academic Article ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.
Academic Article A functional promoter polymorphism of the d-globin gene is a specific marker of the Arab-Indian haplotype.
Academic Article Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
Academic Article Multiple loci influencing hippocampal degeneration identified by genome scan.
Academic Article Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.
Academic Article Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample.
Academic Article d-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.
Academic Article Behavioral variant frontotemporal lobar degeneration with amyotrophic lateral sclerosis with a chromosome 9p21 hexanucleotide repeat.
Academic Article Prayer at midlife is associated with reduced risk of cognitive decline in Arabic women.
Academic Article Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
Academic Article Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
Academic Article Seven new loci associated with age-related macular degeneration.
Academic Article Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype.
Academic Article GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
Academic Article SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
Academic Article Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans.
Academic Article Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
Academic Article A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.
Academic Article Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts.
Academic Article Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.
Academic Article Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).
Academic Article Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics.
Academic Article APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis.
Academic Article Locating genetic modifiers for inherited neurodegenerative diseases
Academic Article Apolipoprotein E genotyping in Alzheimer’s disease
Academic Article Molecular genetics of autosomal dominant familial Alzheimer's disease
Academic Article Determining the genetic component of a disease
Academic Article Alzheimer’s disease and diet
Academic Article Genetic and environmental risk factors for Alzheimer’s disease in Arabs residing in Israel
Academic Article The genetic component in Parkinson disease is half that of Alzheimer disease
Academic Article DNA markers at 13q14-q22 linked to Wilson's disease
Academic Article Application of database techniques in medical genetics
Academic Article Alzheimer disease and the fronto-temporal dementias: diseases with cerebral deposition of fibrillar proteins
Academic Article Letter to the Editor: Suicide and presymptomatic testing in Huntington disease
Academic Article Book review: Hannah's Heirs: The Quest for the Genetic Origins of Alzheimer's Disease
Academic Article Age at onset of Alzheimer Disease is influenced by multiple genetic and non-genetic factors: The MIRAGE Study
Academic Article Effects of smoking, alcohol and APOE genotype on Alzheimer disease: The MIRAGE Study
Academic Article Genetic neurodegenerative disease models for human aging
Academic Article Book review: Alzheimer's Disease and the Environment (Royal Society of Medicine Services, Round Table Series, No. 26)
Academic Article Risk of dementia in first degree relatives of patients with Alzheimer's disease
Academic Article Linkage map of anonymous loci near the CF gene.
Academic Article Molecular genetics of familial Alzheimer's disease and its implications
Academic Article Risk of Alzheimer disease is associated with parental age among apolipoprotein E e4 heterozygotes
Academic Article Reliability of self-reported age at onset of major depression.
Academic Article Assessment of genetic risk for Alzheimer's disease among first-degree relatives.
Academic Article A linkage group of five DNA markers on human chromosome 10.
Academic Article An anthropometric assessment of Huntington's disease patients and families.
Academic Article Suicide and attempted suicide in Huntington disease: implications for preclinical testing of persons at risk.
Academic Article Predictability of phenotype in Huntington's disease.
Academic Article Diabetes mellitus in Huntington disease.
Academic Article A genetic model for age at onset in Huntington disease.
Academic Article Anthropometric discrimination among affected, at-risk, and not-at-risk individuals in families with Huntington disease.
Academic Article Predicting genotypes at loci for autosomal recessive disorders using linked genetic markers: application to Wilson's disease.
Academic Article Clinical anthropometry and medical genetics: a compilation of body measurements in genetic and congenital disorders.
Academic Article Evidence for linkage between Wilson disease and esterase D in three kindreds: detection of linkage for an autosomal recessive disorder by the family study method.
Academic Article Development of a map of chromosome 11p.
Academic Article Mapping the Wilson disease locus to a cluster of linked polymorphic markers on chromosome 13.
Academic Article Managing data for genetic linkage analysis.
Academic Article Automating data manipulation for genetic analysis using a data base management system.
Academic Article Assignment of the gene for Wilson disease to chromosome 13: linkage to the esterase D locus.
Academic Article The natural history of Huntington disease: possible role of "aging genes".
Academic Article Inverse relationship between age at onset of Huntington disease and paternal age suggests involvement of genetic imprinting.
Academic Article A test of the hypothesis that age at onset in Huntington disease is controlled by an X-linked recessive modifier.
Academic Article Does the omission of missing information bias the estimates of age-at-onset distributions?
Academic Article Segregation analysis in Alzheimer disease: no evidence for a major gene.
Academic Article Gender equality in Machado-Joseph disease.
Academic Article Chromosome 13q deletion with Waardenburg syndrome: further evidence for a gene involved in neural crest function on 13q.
Academic Article [A systematic genetic-epidemiologic family study of patients with Alzheimer disease--experience with the MIRAGE study in Germany].
Academic Article Multiple etiologies for Alzheimer disease are revealed by segregation analysis.
Academic Article Linkage of late-onset Alzheimer''s disease with apolipoprotein E type 4 on chromosome 19.
Academic Article Machado Joseph disease is not an allele of the spinocerebellar ataxia 2 locus.
Academic Article Interrater agreement for diagnosis of Alzheimer's disease: the MIRAGE study.
Academic Article Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
Academic Article Integrating GWASs and human protein interaction networks identifies a gene subnetwork underlying alcohol dependence.
Academic Article A case of inappropriate apolipoprotein e testing in Alzheimer''s disease due to lack of an informed consent discussion.
Academic Article Data compatibility in the addiction sciences: an examination of measure commonality.
Academic Article Association of MAPT haplotypes with Alzheimer''s disease risk and MAPT brain gene expression levels.
Academic Article F-box/LRR-repeat protein 7 is genetically associated with Alzheimer''s disease.
Academic Article A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
Academic Article Genome-wide association study of the rate of cognitive decline in Alzheimer''s disease.
Academic Article Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.
Academic Article Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.
Academic Article Gene-wide analysis detects two new susceptibility genes for Alzheimer''s disease.
Academic Article Genetic risk prediction and neurobiological understanding of alcoholism.
Academic Article Estimating the risk for conversion from mild cognitive impairment to Alzheimer''s disease in an elderly Arab community.
Academic Article Eye color: A potential indicator of alcohol dependence risk in European Americans.
Academic Article The ticking clock of Cayo Santiago macaques and its implications for understanding human circadian rhythm disorders.
Academic Article Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.
Academic Article Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer''s disease.
Academic Article Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
Academic Article Follow-up of loci from the International Genomics of Alzheimer''s Disease Project identifies TRIP4 as a novel susceptibility gene.
Academic Article Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.
Academic Article Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Academic Article Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes.
Academic Article Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.
Academic Article Protective variant for hippocampal atrophy identified by whole exome sequencing.
Academic Article Ancestry of the Timorese: age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world.
Academic Article Variations in opioid receptor genes in neonatal abstinence syndrome.
Academic Article Evidence of CNIH3 involvement in opioid dependence.
Academic Article Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.
Academic Article Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways.
Academic Article Missense variant in TREML2 protects against Alzheimer''s disease.
Academic Article Reply: To PMID 23740775.
Academic Article The a-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder.
Academic Article FLT1 genetic variation predisposes to neovascular AMD in ethnically diverse populations and alters systemic FLT1 expression.
Academic Article Genetic risk prediction and neurobiological understanding of alcoholism.
Academic Article Genome-wide association meta-analysis of neuropathologic features of Alzheimer''s disease and related dementias.
Academic Article Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
Academic Article Convergent genetic and expression data implicate immunity in Alzheimer''s disease.
Academic Article Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence?
Academic Article Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
Academic Article Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort.
Academic Article Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.
Academic Article ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.
Academic Article Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans.
Academic Article A novel Alzheimer disease locus located near the gene encoding tau protein.
Academic Article Expanding the genomic roadmap of Alzheimer''s disease.
Academic Article Genome-wide association study of body mass index in subjects with alcohol dependence.
Academic Article PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.
Academic Article A rare mutation in UNC5C predisposes to late-onset Alzheimer''s disease and increases neuronal cell death.
Academic Article Global and local ancestry in African-Americans: Implications for Alzheimer''s disease risk.
Academic Article Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
Academic Article Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants.
Academic Article Critical evaluation of transcription factor Atf2 as a candidate modulator of alcohol preference in mouse and human populations.
Academic Article Genome-wide association study of copy number variations (CNVs) with opioid dependence.
Academic Article Genetic overlap between Alzheimer''s disease and Parkinson''s disease at the MAPT locus.
Academic Article BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia.
Academic Article Genomewide Association Study for Maximum Number of Alcoholic Drinks in European Americans and African Americans.
Academic Article Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
Academic Article Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks.
Academic Article Assessment of the genetic variance of late-onset Alzheimer''s disease.
Academic Article Reply: To PMID 25559091.
Academic Article Further analyses support the association between light eye color and alcohol dependence.
Academic Article Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions.
Academic Article Two novel loci, COBL and SLC10A2, for Alzheimer''s disease in African Americans.
Academic Article ABCA7 frameshift deletion associated with Alzheimer disease in African Americans.
Academic Article Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.
Academic Article Homozygosity for a haplotype in the HBG2-OR51B4 region is exclusive to Arab-Indian haplotype sickle cell anemia.
Academic Article Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer''s brain.
Academic Article Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer''s disease.
Academic Article Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.
Academic Article Genetic Relationship between Schizophrenia and Nicotine Dependence.
Academic Article The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene.
Academic Article Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity.
Academic Article Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer''s disease.
Academic Article Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.
Academic Article Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease.
Academic Article A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke.
Academic Article Network-driven plasma proteomics expose molecular changes in the Alzheimer''s brain.
Academic Article A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.
Academic Article Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms.
Academic Article S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours.
Academic Article Genome-wide association study identifies four novel loci associated with Alzheimer''s endophenotypes and disease modifiers.
Academic Article Transethnic genome-wide scan identifies novel Alzheimer''s disease loci.
Academic Article A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer''s Disease Brains.
Academic Article Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1.
Academic Article Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
Academic Article Largest GWAS of PTSD (N=20?070) yields genetic overlap with schizophrenia and sex differences in heritability.
Grant Genetic Basis of Cerebrovascular Mechanisms in Alzheimer’s Disease
Grant Genetic Epidemiological Studies of Alzheimer Disease
Grant Centenarian Offspring and Control for Longitudinal Study
Grant Genetic Factor Underlying Alzheimer Disease
Grant Family Based Studies of Gene-Environment Interactions in Alzheimer’s Disease
Grant Mapping of the Alzheimer’s Disease Susceptibility Gene on Chromosome 12
Grant Biomedical Research Support Program in Genetics
Grant Multi-Ethnic Genome Wide Alzheimer’s Association
Academic Article A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer''s disease.
Academic Article Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer''s disease.
Academic Article Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study.
Academic Article Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport.
Academic Article A phased SNP-based classification of sickle cell anemia HBB haplotypes.
Academic Article Genetics of age-related macular degeneration (AMD).
Academic Article Genetics of age-related macular degeneration (AMD).
Academic Article Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior.
Academic Article Caspase-8, association with Alzheimer''s Disease and functional analysis of rare variants.
Academic Article Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.
Academic Article Ancestry-specific and sex-specific risk alleles identified in a genome-wide gene-by-alcohol dependence interaction study of risky sexual behaviors.
Academic Article Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.
Academic Article Genome-wide association study identifies a novel locus for cannabis dependence.
Academic Article Exome Sequencing of Extended Families with Alzheimer''s Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function.
Academic Article A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.
Academic Article The Alzheimer''s Disease Sequencing Project: Study design and sample selection.
Academic Article Genome-wide association study of Alzheimer''s disease endophenotypes at prediagnosis stages.
Academic Article Human induced pluripotent stem cells illuminate pathways and novel treatment targets for age-related macular degeneration.
Academic Article Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer''s disease.
Academic Article Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.
Academic Article Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer''s Disease Sequencing Project.
Academic Article Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Academic Article FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-p Interactions.
Academic Article One for all and all for One: Improving replication of genetic studies through network diffusion.
Academic Article Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer''s disease.
Academic Article Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response.
Academic Article Analysis of shared heritability in common disorders of the brain.
Academic Article Genome-wide association meta-analysis of age at first cannabis use.
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Award or Honor Receipt Distinguished Alumnus Award
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Award or Honor Receipt Jack Spivack Excellence in Neuroscience Research Award
Academic Article F131. Genome-Wide Association Study Identifies Glutamate Ionotropic Receptor GRIA4 as a Risk Gene for Comorbid Nicotine Dependence and Major Depression
Academic Article NOVEL GENETIC VARIANTS ASSOCIATED WITH FAMILIAL LATE-ONSET ALZHEIMER DISEASE IN THE ALZHEIMER’S DISEASE SEQUENCING PROJECT
Academic Article SEX-SPECIFIC ANALYSIS OF THE ADSP CASE-CONTROL WHOLE-EXOME SEQUENCING DATASET
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: CASE-CONTROL ANALYSES
Academic Article CEREBROSPINAL FLUID ENDOPHENOTYPES PROVIDE INSIGHT INTO BIOLOGY UNDERLYING ALZHEIMER'S DISEASE
Academic Article BIVARIATE GENOME-WIDE ASSOCIATION STUDY OF NEUROPATHOLOGIC FEATURES OF ALZHEIMER’S DISEASE
Academic Article GENOME-WIDE RARE VARIANT IMPUTATION AND TISSUE-SPECIFIC TRANSCRIPTOMIC ANALYSIS IDENTIFY NOVEL RARE VARIANT CANDIDATE LOCI IN LATE-ONSET ALZHEIMER’S DISEASE: THE ALZHEIMER’S DISEASE GENETICS CONSORTIUM
Academic Article GENOME-WIDE ASSOCIATION STUDY OF ALZHEIMER DISEASE ENDOPHENOTYPES AT PRECLINICAL AND MCI STAGES
Academic Article Genome-Wide Association Study Identifies HTR2B as a Risk Variant of Cannabis-Related Aggression in African Americans
Academic Article FURTHER STRATIFICATION OF APOE E4-NEGATIVE SUBJECTS IDENTIFIES NOVEL GENES FOR ALZHEIMER'S DISEASE
Academic Article HIGH-RESOLUTION IMPUTATION IN GENOME-WIDE ASSOCIATION STUDIES OF LATE-ONSET ALZHEIMER'S DISEASE IDENTIFIES NOVEL RARE VARIANT ASSOCIATIONS
Academic Article A COMMON ALLELE IN SPI1 LOWERS RISK AND DELAYS AGE AT ONSET FOR ALZHEIMER'S DISEASE
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: SEARCH FOR ALZHEIMER'S DISEASE RESILIENCE GENES THAT MAY MODIFY DISEASE SUSCEPTIBILITY IN SPECIFIC APOE GENOTYPE BACKGROUNDS
Academic Article RARE DELETERIOUS AND LOSS-OF-FUNCTION VARIANTS IN OPRL1 AND GAS2L2 CONTRIBUTE TO THE RISK OF LATE-ONSET ALZHEIMER’S DISEASE: ALZHEIMER’S DISEASE SEQUENCING PROJECT CASE-CONTROL STUDY
Academic Article IDENTIFICATION OF NOVEL CANDIDATE GENES FOR EARLY-ONSET ALZHEIMER'S DISEASE THROUGH INTEGRATED WHOLE-EXOME SEQUENCING AND EXOME CHIP ARRAY ASSOCIATION ANALYSIS
Academic Article Exome array analysis identifies novel risk variants for Alzheimer's disease with onset before 65 years
Academic Article LOW-FREQUENCY VARIANT IMPUTATION IDENTIFIES NOVEL DISEASE-ASSOCIATED LOCI IN A GENOME-WIDE ASSOCIATION STUDY OF LATE-ONSET ALZHEIMER'S DISEASE
Academic Article WHOLE-EXOME SEQUENCING OF HISPANIC EARLY-ONSET ALZHEIMER DISEASE FAMILIES IDENTIFIES RARE VARIANTS IN MULTIPLE ALZHEIMER'S-RELATED GENES
Academic Article A VARIANT IN STK24 ACHIEVES GENOME-WIDE SIGNIFICANCE IN AFRICAN AMERICANS USING A LIABILITY MODEL
Academic Article Ttn as a likely causal gene for QTL of alcohol preference on mouse chromosome 2
Academic Article Genome-wide association study in different clinical stages of Alzheimer’s disease
Academic Article Analyzing pathway specificity of variants associated with Alzheimer’s disease from the scientific literature corpus
Academic Article Speaker 4: Joel Gelernter, USA
Academic Article PM296. SORCS2 regulates alcohol withdrawal severity and excitatory synaptic transmission
Academic Article STRUCTURAL VARIATION (SV) IN HETEROGENOUS WHOLE-GENOME SEQUENCING DATA FROM 111 FAMILIES AT RISK FOR ALZHEIMER'S DISEASE: ALZHEIMER'S DISEASE SEQUENCING PROJECT SV STUDY
Academic Article Transethnic genome-wide meta-analysis for Alzheimer disease
Academic Article MULTIVARIATE PHENOTYPES ASSOCIATION STUDY OF NEUROPATHOLOGICAL FEATURES OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS
Academic Article Low-frequency variant imputation identifies rare variant candidate loci in a gwas of late-onset Alzheimer’s disease in the igap consortium
Academic Article ABCA7 deletion associated with Alzheimer's disease in African Americans
Academic Article The role of common and rare variants in risk for Alzheimer's disease across populations
Academic Article Genome-wide association study identifies susceptibility loci associated with the rate of cognitive decline
Academic Article Protective variant for rate of hippocampal volume loss identified by whole exome sequencing in APOE-e3e3 males with MCI
Academic Article Genetic variation in PLXNA4 associated with susceptibility of Alzheimer’s disease through tau phosphorylation
Academic Article Genome-wide association analyses of onset age in late-onset Alzheimer disease (LOAD) demonstrate no strong effect outside of the APOE region
Academic Article Candidate gene study in the endosome-to-Golgi retrieval pathway reveals association of retromer genes with Alzheimer's disease
Academic Article Genetic association of variants with late-onset Alzheimer's disease risk and brain gene expression
Academic Article ALCOHOL DEPENDENCE GWAS IN TWO POPULATIONS WITH CONSIDERATION OF SUICIDE-RELATED TRAITS
Academic Article LINKAGE AND ASSOCIATION STUDIES OF CANNABIS DEPENDENCE SUGGEST NRG1 AS A RISK LOCUS
Academic Article Two rare AKAP9 variants are associated with Alzheimers disease in African Americans
Academic Article ADGC+: An expanded Alzheimer's Disease Genetics Consortium (ADGC) genome-wide association study
Academic Article The identification of rare variants in late-onset Alzheimer’s disease using extended families
Academic Article Late-onset Alzheimer’s disease neuropathology genomic screen identifies novel loci for neuritic plaque and other Alzheimer’s neuropathology features
Academic Article A review of published genetic studies using ADNI multimodality quantitative phenotypes: MRI, PET, fluid biomarkers, cognition and clinical status
Academic Article Genome-wide association study for cognitive decline
Academic Article Correction: ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure
Academic Article Association of TREM2 variants with Alzheimer's disease in African-Americans: For the Alzheimer's Disease Genetics Consortium (ADGC)
Academic Article APP associated with late-onset Alzheimer's disease in an autopsy-confirmed dataset
Academic Article Structural, functional and molecular imaging as intermediate phenotypes for studies of candidate genes, pathways and GWAS in Alzheimer's disease
Academic Article A rare mutation in the CTNND2 gene is associated with increased Aß42 secretion
Academic Article Genome-wide association study of Alzheimer's-related brain MRI traits identifies several loci influencing degeneration of the hippocampus
Academic Article CTNNA3, CAPRIN2 and SPG20 are significantly associated with Alzheimer's disease in preliminary analyses of a genome-wide association study in African-Americans
Academic Article Intracellular Traffic and Neurodegenerative Disorders
Academic Article Clustering Based on Genetic Ancestry
Academic Article Mild Parkinsonian Signs (MPS) Are Associated with Mild Cognitive Impairment (MCI) but Not Predictive of Progression to Alzheimer's Disease (AD) in a Door-to-Door Study of an Elderly Arab Population
Academic Article U.S. Alzheimer's Disease Genetics Consortium: Organization and results
Academic Article Genome-wide Association of Cerebrovascular and Neurodegenerative Quantitative MRI Traits in Alzheimer's Disease
Academic Article GENETIC MODERATION OF ADVERSE CHILDHOOD EVENTS AND RISK OF DEPRESSION AND SUBSTANCE DEPENDENCE
Academic Article GENOMEWIDE STUDIES OF ALCOHOL DEPENDENCE
Academic Article Comparison of Family Based Methods For Genome-Wide Association Study In the Framingham Eye Study
Academic Article A Genomewide Association Study Of Plasma Total IGE In The Framingham Heart Study Identifies HLA-A As A Susceptibility Locus
Academic Article Identification of Gene-Gene Interactions in Alzheimer Disease Using CoOperative Game Theory
Academic Article Genome-Wide Scan Suggested Novel Alzheimer’s Disease Susceptibility Genes by Factoring Influence of APOE
Academic Article The ADGC genome browser
Academic Article Genetic Associations between VPS10 Receptor Genes and Late-Onset Alzheimer's Disease
Academic Article The genetics of Alzheimer's disease
Academic Article Using CSF biomarkers to replicate genetic associations in Alzheimer's disease.
Academic Article Statin use is associated with reduced risk of Alzheimer's disease
Academic Article Polymorphism in the cyclooxygenase-2 (COX-2) and presenilin 2 (PS2) gene promoters: Impact on inflammatory signaling and potential contribution to the etiopathology of Alzheimer's disease (AD)
Academic Article Genetic polymorphisms associated with fetal hemoglobin response to hydroxyurea in patients with sickle cell anemia
Academic Article Recent findings from a genomewide linkage scan for cocaine dependence
Academic Article Polymorphisms in paraoxonase genes PON1, PON2 and PON3 are associated with late onset Alzheimer disease
Academic Article Modeling genetic polymorhphisms and sickle cell associated vasoocclusive events using classification and regression trees (CART)
Academic Article Polymorphisms (Snps) in multiple genes of the Tgf-beta/Bmp pathway are associated with a global measure of sickle cell disease severity
Academic Article Modeling Genetic Polymorphisms and Sickle Cell Associated Vasoocclusive Events Using Classification and Regression Trees (CART) and Stochastic Gradient Boosting (SGB)
Academic Article P2-060: Comparison of Alzheimer and vascular dementia patients using MRI-based measures of atrophy
Academic Article Adherence in Internet interventions for anxiety and depression: Systematic review
Academic Article CLONING THE WILSON DISEASE GENE
Academic Article 219Cross-national comparison of risk factors for Alzheimer's disease: Same genetic risk in different environments?
Academic Article The use of consanguineous families from isolated populations to identify genes for recessive, non-syndromal deafness
Academic Article Localization of a gene for blood pressure regulation to human chromosome 18q
Academic Article Candidate genes associated with Alzheimer's disease
Academic Article Analysis of candidate genes of chromosome 12P
Academic Article A genetic linkage study on late-onset familial Alzheimer's disease does not provide strong evidence for linkage to chromosome 1Q22, 9Q21.1, 10Q23, and chromosome 11Q23.3
Academic Article Does hypertension affect the risk and age at onset of Alzheimer disease?
Academic Article Genetic linkage studies of Alzheimer's disease in Israeli arabs
Academic Article The REVEAL study: A new model for susceptibility genotyping. risk assessment and counseling for Alzheimer's disease
Academic Article Preliminary findings from the REVEAL Study: Genetic risk assessment and counseling for Alzheimer's disease
Academic Article Authors' response to commentaries
Academic Article Response to Kessler: Suicide and presymptomatic testing in Huntington disease
Academic Article SEARCHING FOR DISEASE MODIFIER GENES IN ß0THALASSEMIA/Hb E
Academic Article A fine structure linkage map for chromosome 13
Academic Article Fetal Hemoglobin In Sickle Cell Anemia: Molecular Characterization of Saudi Patients From the Eastern Province
Academic Article Whole exome sequencing study identifies novel rare and common Alzheimer''s-Associated variants involved in immune response and transcriptional regulation.
Academic Article Genome-wide association study of cognitive flexibility assessed by the Wisconsin Card Sorting Test.
Academic Article Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer''s disease.
Academic Article Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants.
Academic Article Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.
Academic Article Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.
Academic Article An efficient analytic approach in genome-wide identification of methylation quantitative trait loci response to fenofibrate treatment.
Academic Article Variation in TMEM106B in chronic traumatic encephalopathy.
Academic Article Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer''s disease.
Academic Article Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.
Academic Article Ancestral origin of ApoE e4 Alzheimer disease risk in Puerto Rican and African American populations.
Academic Article A rare missense variant of CASP7 is associated with familial late-onset Alzheimer''s disease.
Academic Article Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease.
Academic Article Comparison of methods for multivariate gene-based association tests for complex diseases using common variants.
Academic Article The genetics and epigenetics of Neonatal Abstinence Syndrome.
Academic Article Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article The Utah Protocol for Postmortem Eye Phenotyping and Molecular Biochemical Analysis.
Academic Article Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry.
Academic Article Salivary microRNAs identified by small RNA sequencing and machine learning as potential biomarkers of alcohol dependence.
Academic Article CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.
Academic Article Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.
Academic Article Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes.
Academic Article A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration.
Academic Article Author Correction: Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Award or Honor Receipt BU Evans Center for Interdisciplinary Biomedical Research Leadership Award
Academic Article APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE e4 on Alzheimer''s Disease Risk in a Multiracial Sample.
Academic Article International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
Academic Article Correction: Whole exome sequencing study identifies novel rare and common Alzheimer''s-Associated variants involved in immune response and transcriptional regulation.
Academic Article A regulatory variant of CHRM3 is associated with cannabis-induced hallucinations in European Americans.
Academic Article Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci.
Academic Article Genome-Wide Association Study of Opioid Cessation.
Academic Article Exceptionally low likelihood of Alzheimer''s dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Academic Article Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Academic Article Genomic influences on self-reported childhood maltreatment.
Academic Article Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium.
Academic Article Prefrontal cortex eQTLs/mQTLs enriched in genetic variants associated with alcohol use disorder and other diseases.
Academic Article Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.
Academic Article Sex-dependent autosomal effects on clinical progression of Alzheimer''s disease.
Academic Article Genome-wide association study of rate of cognitive decline in Alzheimer''s disease patients identifies novel genes and pathways.
Academic Article Genetic variants and functional pathways associated with resilience to Alzheimer''s disease.
Academic Article Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease.
Academic Article Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.
Academic Article A large-scale genome-wide association study meta-analysis of cannabis use disorder.
Grant The Alzheimer Disease Sequencing Analysis Collaborative
Grant Precision Monitoring and Assessment in the Framingham Study: Cognitive, MRI, Genetic and Biomarker Precursors of AD & Dementia
Grant Alzheimer Disease Genetic Architecture in African Americans
Grant International Alzheimer's Disease Genetics Consortium
Grant Alzheimer's Disease Genetics Consortium
Grant Coordinating Center for Genetics and Genomics of Alzheimer's Disease
Grant Alzheimer's Disease Genetics Consortium
Grant Genetic Studies of Alzheimer Disease in Koreans
Grant Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-AD
Grant Institutional Program Unifying Population and Laboratory Based Sciences Award
Grant Genomic and Biological Studies of APOE e2 in Alzheimer's Disease
Grant Genetic Mechanisms Shared by Eye and Brain Diseases as Novel Therapeutic Targets for Age-Related macular Degeneration
Grant Alzheimer Disease Genetic Architecture in African Americans
Grant Personnel Agreement for Research Services of Mark Logue
Grant Coordinating Center for Genetics and Genomics of Alzheimer's Disease
Grant Identifying Methamphetamine Risk Variants by Extreme Phenotype Exome Sequencing
Grant Consortium for Alzheimer Sequencing and Analysis (CASA)
Grant Alzheimer Disease Genetics Consortium
Academic Article Analysis of telomere length variation and Shelterin complex subunit gene expression changes in ethanol-exposed human embryonic stem cells.
Academic Article Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.

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