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Research Expertise & Professional Interests Dr. Lindsay Farrer is a medical geneticist at Boston University Schools of Medicine and Public Health where he is the Boston University Distinguished Professor of Genetics, Chief of Biomedical Genetics, and a Professor of Medicine, Neurology, Ophthalmology, Epidemiology, and Biostatistics. Dr. Farrer is a graduate of the University of North Carolina in Chapel Hill, received his Ph.D. from the Indiana University School of Medicine, and gained additional training in genetic epidemiology at Yale University. He holds adjunct faculty positions at Harvard Medical School, Massachusetts General Hospital, and the Veterans Administration Medical Center in Bedford, Massachusetts. He is a Founding Fellow of the American College of Medical Genetics. Dr. Farrer teaches several courses in human genetics and addiction science at Boston University, directs the BU Transformative Training Program in Addiction Science (TTPAS) that features transdisciplinary training for students enrolled in PhD programs across the Medical and Charles River campuses, directs Boston University’s Molecular Genetics Core Facility which offers DNA genotyping and sequencing services to investigators at Boston University and elsewhere, and provides genetic counseling and testing to patients with a variety of inherited conditions. Dr. Farrer’s research has lead to more than 450 publications on genetic risk factors for several familial neurodegenerative and other chronic diseases. In collaboration with other laboratories worldwide, his group has localized genes causing a variety of rare and common disorders, most notably Alzheimer disease (AD), substance use disorders (SUDs), age-related macular degeneration (AMD), Wilson disease, Machado-Joseph disease, Waardenburg syndrome, hypertension, sensorineural deafness, and osteoarthritis. His group identified a functional genetic variant in the complement factor H gene which accounts for more than 30% of the attributable risk for AMD, the leading cause of progressive vision loss and blindness in the elderly. In collaboration with other researchers, Dr. Farrer is conducting genome wide association studies (GWAS) and whole genome/exome sequencing studies for several disorders including AD, SUDs (cocaine, opiates, nicotine, alcohol and cannabis), and AMD. Dr. Farrer’s team is also developing methods for locating genes that influence the natural history of complex diseases and pharmacogenetic response. Under Dr. Farrer’s leadership, the MIRAGE Project, a multi-center study of AD funded since 1991 by the National Institute on Aging, has made several important contributions to our understanding of the interactions between genetic and environmental factors for the disorder. This study has a particular emphasis on the genetics of AD in African Americans. MIRAGE was the first study to demonstrate that genetic factors have a major role in the development of AD and that APOE e4 is more weakly associated with disease in men and persons older than 75 years. Dr. Farrer co-directed the international effort which demonstrated that SORL1 is genetically and functionally associated with AD, thus implicating intracellular protein trafficking as integral pathway in AD. His laboratory conducted genome wide association studies (GWAS) for AD in several populations including African Americans and an inbred Israeli-Arab community, and identified rare AD causal mutations in the AKAP9 gene which are specific to African Americans. Dr. Farrer serves on the Executive Committee of the national Alzheimer Disease Genetics Consortium and co-directs the data analysis effort for this large NIH-funded project. He is also a Principal Investigator of the national Alzheimer Disease Sequencing Project and a study to identify AD risk and protective variants in Koreans.
Self-Described Keywords Alzheimer disease

One or more keywords matched the following items that are connected to Farrer, Lindsay

Item TypeName
Concept Alzheimer Disease
Academic Article Statement on use of apolipoprotein E testing for Alzheimer disease. American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer disease.
Academic Article Apolipoprotein E genotype in patients with Alzheimer's disease: implications for the risk of dementia among relatives.
Academic Article Rate of progression of Alzheimer's disease is associated with genetic risk.
Academic Article A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21.
Academic Article Estimating the probability for major gene Alzheimer disease.
Academic Article Susceptibility genes for familial Alzheimer's disease on chromosomes 19 and 21: a reality check.
Academic Article Genetic transmission of Alzheimer's disease among families in a Dutch population based study.
Academic Article Presenilin polymorphisms in Alzheimer's disease.
Academic Article No genetic effect of alpha1-antichymotrypsin in Alzheimer disease.
Academic Article Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old?
Academic Article Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4.
Academic Article No association between alpha 1-antichymotrypsin and familial Alzheimer's disease.
Academic Article The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective.
Academic Article No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease.
Academic Article Apolipoprotein E epsilon2 does not increase risk of early-onset sporadic Alzheimer's disease.
Academic Article Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
Academic Article Amyloid-beta-protein isoforms in brain of subjects with PS1-linked, beta APP-linked and sporadic Alzheimer disease.
Academic Article Absence of association between Alzheimer disease and the -491 regulatory region polymorphism of APOE.
Academic Article Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity.
Academic Article Smoking and risk of Alzheimer's disease. MIRAGE Study Group.
Academic Article Association between bleomycin hydrolase and Alzheimer's disease in caucasians.
Academic Article An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease.
Academic Article Alpha-2 macroglobulin gene in early- and late-onset Alzheimer disease.
Academic Article Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease.
Academic Article No association between the HLA-A2 allele and Alzheimer disease.
Academic Article Familial risk for Alzheimer disease in ethnic minorities: nondiscriminating genes.
Academic Article Association between angiotensin-converting enzyme and Alzheimer disease.
Academic Article Intercontinental epidemiology of Alzheimer disease: a global approach to bad gene hunting.
Academic Article No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease.
Academic Article Head injury and the risk of AD in the MIRAGE study.
Academic Article Reliability of information collected by proxy in family studies of Alzheimer's disease.
Academic Article Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition.
Academic Article The angiotensin-converting enzyme gene as a possible risk or protective factor in Alzheimer's disease.
Academic Article Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.
Academic Article Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.
Academic Article Risk of dementia among white and African American relatives of patients with Alzheimer disease.
Academic Article Association between apolipoprotein E genotype and Alzheimer disease in African American subjects.
Academic Article Genetic and environmental risk factors for Alzheimer's disease in Israeli Arabs.
Academic Article Regulatory region variability in the human presenilin-2 (PSEN2) gene: potential contribution to the gene activity and risk for AD.
Academic Article Monozygotic twins concordant for late-onset probable Alzheimer disease with suspected Alzheimer disease in four sibs.
Academic Article Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community.
Academic Article Comparison of Alzheimer's disease risk factors in white and African American families.
Academic Article Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer disease.
Academic Article Differences between African Americans and Whites in their attitudes toward genetic testing for Alzheimer's disease.
Academic Article Depression as a risk factor for Alzheimer disease: the MIRAGE Study.
Academic Article Genetic and environmental epidemiology of Alzheimer's disease in arabs residing in Israel.
Academic Article The genetics of adult-onset neuropsychiatric disease: complexities and conundra?
Academic Article Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
Academic Article Estimating risk curves for first-degree relatives of patients with Alzheimer's disease: the REVEAL study.
Academic Article Who seeks genetic susceptibility testing for Alzheimer's disease? Findings from a multisite, randomized clinical trial.
Academic Article Postmenopausal hormone therapy and Alzheimer's disease risk: interaction with age.
Academic Article Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study.
Academic Article APOE, vascular pathology, and the AD brain.
Academic Article Polymorphisms in the PON gene cluster are associated with Alzheimer disease.
Academic Article Association studies between the plasmin genes and late-onset Alzheimer's disease.
Academic Article Predictors of subjective memory complaint in cognitively normal relatives of patients with Alzheimer's disease.
Academic Article Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study.
Academic Article Association of polymorphisms in the Angiotensin-converting enzyme gene with Alzheimer disease in an Israeli Arab community.
Academic Article Genetic association between endothelial nitric oxide synthase and Alzheimer disease.
Academic Article The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.
Academic Article Segregation analysis reveals evidence of a major gene for Alzheimer disease.
Academic Article The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort.
Academic Article Association of decreased paternal age and late-onset Alzheimer's disease. An example of genetic imprinting?
Academic Article Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future.
Academic Article Heritability of magnetic resonance imaging (MRI) traits in Alzheimer disease cases and their siblings in the MIRAGE study.
Academic Article Association between SORL1 and Alzheimer's disease in a genome-wide study.
Academic Article Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.
Academic Article Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience.
Academic Article Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity.
Academic Article Estimation of familial risk in Alzheimer's disease.
Academic Article Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.
Academic Article Performance of random forest when SNPs are in linkage disequilibrium.
Academic Article Magnetic resonance imaging traits in siblings discordant for Alzheimer disease.
Academic Article Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.
Academic Article Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.
Academic Article Statin use and the risk of Alzheimer's disease: the MIRAGE study.
Academic Article Disclosure of APOE genotype for risk of Alzheimer's disease.
Academic Article Hypertension increases the probability of Alzheimer's disease and of mild cognitive impairment in an Arab community in northern Israel.
Academic Article Education attenuates the effect of medial temporal lobe atrophy on cognitive function in Alzheimer's disease: the MIRAGE study.
Academic Article Molecular genetics of familial Alzheimer's disease.
Academic Article Familial Alzheimer's disease: progress and problems.
Academic Article Molecular genetics of familial Alzheimer's disease.
Academic Article Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study.
Academic Article Head circumference, atrophy, and cognition: implications for brain reserve in Alzheimer disease.
Academic Article Healthy aging and preclinical dementia: the United States-Israel Longitudinal Database project.
Academic Article Meta-analysis of the association between variants in SORL1 and Alzheimer disease.
Academic Article SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.
Academic Article Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans.
Academic Article Genome-wide analysis of genetic loci associated with Alzheimer disease.
Academic Article Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
Academic Article Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.
Academic Article Identification of novel candidate genes for Alzheimer's disease by autozygosity mapping using genome wide SNP data.
Academic Article Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.
Academic Article Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Academic Article Genetics and genomics of late-onset Alzheimer's disease and its endophenotypes.
Academic Article Magnetic resonance imaging-measured atrophy and its relationship to cognitive functioning in vascular dementia and Alzheimer's disease patients.
Academic Article A comprehensive genetic association study of Alzheimer disease in African Americans.
Academic Article High prevalence of mild cognitive impairment and Alzheimer's disease in arabic villages in northern Israel: impact of gender and education.
Academic Article Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases.
Academic Article Identification of Alzheimer disease-associated variants in genes that regulate retromer function.
Academic Article Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants.
Academic Article Genome-wide association study of Alzheimer's disease.
Academic Article Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
Academic Article Multiple loci influencing hippocampal degeneration identified by genome scan.
Academic Article Comprehensive search for Alzheimer disease susceptibility loci in the APOE region.
Academic Article d-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.
Academic Article Prayer at midlife is associated with reduced risk of cognitive decline in Arabic women.
Academic Article Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
Academic Article GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
Academic Article SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
Academic Article Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans.
Academic Article Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts.
Academic Article Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment.
Academic Article Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).
Academic Article Apolipoprotein E genotyping in Alzheimer’s disease
Academic Article Molecular genetics of autosomal dominant familial Alzheimer's disease
Academic Article Alzheimer’s disease and diet
Academic Article Genetic and environmental risk factors for Alzheimer’s disease in Arabs residing in Israel
Academic Article The genetic component in Parkinson disease is half that of Alzheimer disease
Academic Article Alzheimer disease and the fronto-temporal dementias: diseases with cerebral deposition of fibrillar proteins
Academic Article Book review: Hannah's Heirs: The Quest for the Genetic Origins of Alzheimer's Disease
Academic Article Age at onset of Alzheimer Disease is influenced by multiple genetic and non-genetic factors: The MIRAGE Study
Academic Article Effects of smoking, alcohol and APOE genotype on Alzheimer disease: The MIRAGE Study
Academic Article Book review: Alzheimer's Disease and the Environment (Royal Society of Medicine Services, Round Table Series, No. 26)
Academic Article Risk of dementia in first degree relatives of patients with Alzheimer's disease
Academic Article Molecular genetics of familial Alzheimer's disease and its implications
Academic Article Risk of Alzheimer disease is associated with parental age among apolipoprotein E e4 heterozygotes
Academic Article Assessment of genetic risk for Alzheimer's disease among first-degree relatives.
Academic Article Segregation analysis in Alzheimer disease: no evidence for a major gene.
Academic Article [A systematic genetic-epidemiologic family study of patients with Alzheimer disease--experience with the MIRAGE study in Germany].
Academic Article Multiple etiologies for Alzheimer disease are revealed by segregation analysis.
Academic Article Linkage of late-onset Alzheimer''s disease with apolipoprotein E type 4 on chromosome 19.
Academic Article Interrater agreement for diagnosis of Alzheimer's disease: the MIRAGE study.
Academic Article A case of inappropriate apolipoprotein e testing in Alzheimer''s disease due to lack of an informed consent discussion.
Academic Article Association of MAPT haplotypes with Alzheimer''s disease risk and MAPT brain gene expression levels.
Academic Article F-box/LRR-repeat protein 7 is genetically associated with Alzheimer''s disease.
Academic Article Genome-wide association study of the rate of cognitive decline in Alzheimer''s disease.
Academic Article Gene-wide analysis detects two new susceptibility genes for Alzheimer''s disease.
Academic Article Estimating the risk for conversion from mild cognitive impairment to Alzheimer''s disease in an elderly Arab community.
Academic Article Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer''s disease.
Academic Article Follow-up of loci from the International Genomics of Alzheimer''s Disease Project identifies TRIP4 as a novel susceptibility gene.
Academic Article Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Academic Article Protective variant for hippocampal atrophy identified by whole exome sequencing.
Academic Article Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers.
Academic Article Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways.
Academic Article Missense variant in TREML2 protects against Alzheimer''s disease.
Academic Article Genome-wide association meta-analysis of neuropathologic features of Alzheimer''s disease and related dementias.
Academic Article Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
Academic Article Convergent genetic and expression data implicate immunity in Alzheimer''s disease.
Academic Article Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.
Academic Article A novel Alzheimer disease locus located near the gene encoding tau protein.
Academic Article Expanding the genomic roadmap of Alzheimer''s disease.
Academic Article PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.
Academic Article A rare mutation in UNC5C predisposes to late-onset Alzheimer''s disease and increases neuronal cell death.
Academic Article Global and local ancestry in African-Americans: Implications for Alzheimer''s disease risk.
Academic Article Genetic overlap between Alzheimer''s disease and Parkinson''s disease at the MAPT locus.
Academic Article Assessment of the genetic variance of late-onset Alzheimer''s disease.
Academic Article Two novel loci, COBL and SLC10A2, for Alzheimer''s disease in African Americans.
Academic Article ABCA7 frameshift deletion associated with Alzheimer disease in African Americans.
Academic Article Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium.
Academic Article Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer''s disease.
Academic Article Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer''s disease.
Academic Article Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.
Academic Article Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease.
Academic Article Network-driven plasma proteomics expose molecular changes in the Alzheimer''s brain.
Academic Article Genome-wide association study identifies four novel loci associated with Alzheimer''s endophenotypes and disease modifiers.
Academic Article Transethnic genome-wide scan identifies novel Alzheimer''s disease loci.
Academic Article A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer''s Disease Brains.
Academic Article Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.
Grant Genetic Basis of Cerebrovascular Mechanisms in Alzheimer’s Disease
Grant Genetic Epidemiological Studies of Alzheimer Disease
Grant Genetic Factor Underlying Alzheimer Disease
Grant Family Based Studies of Gene-Environment Interactions in Alzheimer’s Disease
Grant Mapping of the Alzheimer’s Disease Susceptibility Gene on Chromosome 12
Academic Article A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer''s disease.
Academic Article Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer''s disease.
Academic Article Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport.
Academic Article Caspase-8, association with Alzheimer''s Disease and functional analysis of rare variants.
Academic Article Exome Sequencing of Extended Families with Alzheimer''s Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function.
Academic Article The Alzheimer''s Disease Sequencing Project: Study design and sample selection.
Academic Article Genome-wide association study of Alzheimer''s disease endophenotypes at prediagnosis stages.
Academic Article Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer''s disease.
Academic Article Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer''s Disease Sequencing Project.
Academic Article Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Academic Article One for all and all for One: Improving replication of genetic studies through network diffusion.
Academic Article Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer''s disease.
Academic Article NOVEL GENETIC VARIANTS ASSOCIATED WITH FAMILIAL LATE-ONSET ALZHEIMER DISEASE IN THE ALZHEIMER’S DISEASE SEQUENCING PROJECT
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: CASE-CONTROL ANALYSES
Academic Article CEREBROSPINAL FLUID ENDOPHENOTYPES PROVIDE INSIGHT INTO BIOLOGY UNDERLYING ALZHEIMER'S DISEASE
Academic Article GENOME-WIDE ASSOCIATION STUDY OF ALZHEIMER DISEASE ENDOPHENOTYPES AT PRECLINICAL AND MCI STAGES
Academic Article FURTHER STRATIFICATION OF APOE E4-NEGATIVE SUBJECTS IDENTIFIES NOVEL GENES FOR ALZHEIMER'S DISEASE
Academic Article HIGH-RESOLUTION IMPUTATION IN GENOME-WIDE ASSOCIATION STUDIES OF LATE-ONSET ALZHEIMER'S DISEASE IDENTIFIES NOVEL RARE VARIANT ASSOCIATIONS
Academic Article A COMMON ALLELE IN SPI1 LOWERS RISK AND DELAYS AGE AT ONSET FOR ALZHEIMER'S DISEASE
Academic Article ALZHEIMER'S DISEASE SEQUENCING PROJECT: SEARCH FOR ALZHEIMER'S DISEASE RESILIENCE GENES THAT MAY MODIFY DISEASE SUSCEPTIBILITY IN SPECIFIC APOE GENOTYPE BACKGROUNDS
Academic Article IDENTIFICATION OF NOVEL CANDIDATE GENES FOR EARLY-ONSET ALZHEIMER'S DISEASE THROUGH INTEGRATED WHOLE-EXOME SEQUENCING AND EXOME CHIP ARRAY ASSOCIATION ANALYSIS
Academic Article Exome array analysis identifies novel risk variants for Alzheimer's disease with onset before 65 years
Academic Article LOW-FREQUENCY VARIANT IMPUTATION IDENTIFIES NOVEL DISEASE-ASSOCIATED LOCI IN A GENOME-WIDE ASSOCIATION STUDY OF LATE-ONSET ALZHEIMER'S DISEASE
Academic Article WHOLE-EXOME SEQUENCING OF HISPANIC EARLY-ONSET ALZHEIMER DISEASE FAMILIES IDENTIFIES RARE VARIANTS IN MULTIPLE ALZHEIMER'S-RELATED GENES
Academic Article Genome-wide association study in different clinical stages of Alzheimer’s disease
Academic Article Analyzing pathway specificity of variants associated with Alzheimer’s disease from the scientific literature corpus
Academic Article STRUCTURAL VARIATION (SV) IN HETEROGENOUS WHOLE-GENOME SEQUENCING DATA FROM 111 FAMILIES AT RISK FOR ALZHEIMER'S DISEASE: ALZHEIMER'S DISEASE SEQUENCING PROJECT SV STUDY
Academic Article Transethnic genome-wide meta-analysis for Alzheimer disease
Academic Article MULTIVARIATE PHENOTYPES ASSOCIATION STUDY OF NEUROPATHOLOGICAL FEATURES OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS
Academic Article Low-frequency variant imputation identifies rare variant candidate loci in a gwas of late-onset Alzheimer’s disease in the igap consortium
Academic Article ABCA7 deletion associated with Alzheimer's disease in African Americans
Academic Article The role of common and rare variants in risk for Alzheimer's disease across populations
Academic Article Genetic variation in PLXNA4 associated with susceptibility of Alzheimer’s disease through tau phosphorylation
Academic Article Genome-wide association analyses of onset age in late-onset Alzheimer disease (LOAD) demonstrate no strong effect outside of the APOE region
Academic Article Candidate gene study in the endosome-to-Golgi retrieval pathway reveals association of retromer genes with Alzheimer's disease
Academic Article Genetic association of variants with late-onset Alzheimer's disease risk and brain gene expression
Academic Article ADGC+: An expanded Alzheimer's Disease Genetics Consortium (ADGC) genome-wide association study
Academic Article The identification of rare variants in late-onset Alzheimer’s disease using extended families
Academic Article Late-onset Alzheimer’s disease neuropathology genomic screen identifies novel loci for neuritic plaque and other Alzheimer’s neuropathology features
Academic Article Genome-wide association study for cognitive decline
Academic Article Association of TREM2 variants with Alzheimer's disease in African-Americans: For the Alzheimer's Disease Genetics Consortium (ADGC)
Academic Article APP associated with late-onset Alzheimer's disease in an autopsy-confirmed dataset
Academic Article Structural, functional and molecular imaging as intermediate phenotypes for studies of candidate genes, pathways and GWAS in Alzheimer's disease
Academic Article CTNNA3, CAPRIN2 and SPG20 are significantly associated with Alzheimer's disease in preliminary analyses of a genome-wide association study in African-Americans
Academic Article Intracellular Traffic and Neurodegenerative Disorders
Academic Article Mild Parkinsonian Signs (MPS) Are Associated with Mild Cognitive Impairment (MCI) but Not Predictive of Progression to Alzheimer's Disease (AD) in a Door-to-Door Study of an Elderly Arab Population
Academic Article U.S. Alzheimer's Disease Genetics Consortium: Organization and results
Academic Article Genome-wide Association of Cerebrovascular and Neurodegenerative Quantitative MRI Traits in Alzheimer's Disease
Academic Article Identification of Gene-Gene Interactions in Alzheimer Disease Using CoOperative Game Theory
Academic Article Genome-Wide Scan Suggested Novel Alzheimer’s Disease Susceptibility Genes by Factoring Influence of APOE
Academic Article Genetic Associations between VPS10 Receptor Genes and Late-Onset Alzheimer's Disease
Academic Article The genetics of Alzheimer's disease
Academic Article Using CSF biomarkers to replicate genetic associations in Alzheimer's disease.
Academic Article Statin use is associated with reduced risk of Alzheimer's disease
Academic Article Polymorphism in the cyclooxygenase-2 (COX-2) and presenilin 2 (PS2) gene promoters: Impact on inflammatory signaling and potential contribution to the etiopathology of Alzheimer's disease (AD)
Academic Article Polymorphisms in paraoxonase genes PON1, PON2 and PON3 are associated with late onset Alzheimer disease
Academic Article 219Cross-national comparison of risk factors for Alzheimer's disease: Same genetic risk in different environments?
Academic Article Candidate genes associated with Alzheimer's disease
Academic Article A genetic linkage study on late-onset familial Alzheimer's disease does not provide strong evidence for linkage to chromosome 1Q22, 9Q21.1, 10Q23, and chromosome 11Q23.3
Academic Article Does hypertension affect the risk and age at onset of Alzheimer disease?
Academic Article Genetic linkage studies of Alzheimer's disease in Israeli arabs
Academic Article The REVEAL study: A new model for susceptibility genotyping. risk assessment and counseling for Alzheimer's disease
Academic Article Preliminary findings from the REVEAL Study: Genetic risk assessment and counseling for Alzheimer's disease
Academic Article Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer''s disease.
Academic Article Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk Variants.
Academic Article Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer''s disease.
Academic Article Ancestral origin of ApoE e4 Alzheimer disease risk in Puerto Rican and African American populations.
Academic Article A rare missense variant of CASP7 is associated with familial late-onset Alzheimer''s disease.
Academic Article Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease.
Academic Article Comparison of methods for multivariate gene-based association tests for complex diseases using common variants.
Academic Article Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry.
Academic Article CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.
Academic Article Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.
Academic Article Author Correction: Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE e4 on Alzheimer''s Disease Risk in a Multiracial Sample.
Academic Article Exceptionally low likelihood of Alzheimer''s dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Academic Article Sex-dependent autosomal effects on clinical progression of Alzheimer''s disease.
Academic Article Genome-wide association study of rate of cognitive decline in Alzheimer''s disease patients identifies novel genes and pathways.
Academic Article Genetic variants and functional pathways associated with resilience to Alzheimer''s disease.
Academic Article Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease.
Academic Article Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.
Grant The Alzheimer Disease Sequencing Analysis Collaborative
Grant Alzheimer Disease Genetic Architecture in African Americans
Grant International Alzheimer's Disease Genetics Consortium
Grant Alzheimer's Disease Genetics Consortium
Grant Coordinating Center for Genetics and Genomics of Alzheimer's Disease
Grant Alzheimer's Disease Genetics Consortium
Grant Genetic Studies of Alzheimer Disease in Koreans
Grant Genomic and Biological Studies of APOE e2 in Alzheimer's Disease
Grant Alzheimer Disease Genetic Architecture in African Americans
Grant Coordinating Center for Genetics and Genomics of Alzheimer's Disease
Grant Alzheimer Disease Genetics Consortium

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