Search Results to Xaralabos Varelas, PhD

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One or more keywords matched the following properties of Varelas, Xaralabos

Research Expertise & Professional Interests Research in the Varelas lab is focused on gaining insight into the molecular mechanisms by which cell fate is coordinated with cell proliferation and survival during animal development and disease. The lab is particularly interested in understanding the roles and regulation of the transcriptional regulators YAP and TAZ (YAP/TAZ), which are key effectors of the Hippo signaling pathway. YAP/TAZ integrate cell polarity and mechanical cues with information relayed by growth factors and chemicals to direct essential processes and maintain organ homeostasis. The lab is incorporating genetic and biochemical approaches to define how YAP/TAZ control developmental events, and how dysregulation of YAP/TAZ activity contributes the etiology of various diseases, such as cancer.
Self-Described Keywords Hippo pathway signaling
Self-Described Keywords Wnt signaling
Self-Described Keywords TGF-beta pathway signaling

One or more keywords matched the following items that are connected to Varelas, Xaralabos

Item TypeName
Concept Signal Transduction
Concept Intercellular Signaling Peptides and Proteins
Concept Intracellular Signaling Peptides and Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Wnt Signaling Pathway
Academic Article The Cdc34/SCF ubiquitination complex mediates Saccharomyces cerevisiae cell wall integrity.
Academic Article TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.
Academic Article Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown.
Academic Article The Hippo pathway regulates Wnt/beta-catenin signaling.
Academic Article The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-ß-SMAD pathway.
Academic Article Integrating developmental signals: a Hippo in the (path)way.
Academic Article Coordinating developmental signaling: novel roles for the Hippo pathway.
Academic Article Stem cell regulation by the Hippo pathway.
Academic Article N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration.
Academic Article The transcriptional regulators TAZ and YAP direct transforming growth factor ß-induced tumorigenic phenotypes in breast cancer cells.
Academic Article Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.
Academic Article Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap.
Academic Article The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren''s syndrome.
Academic Article Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Academic Article A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma.
Academic Article The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.
Academic Article Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling.
Academic Article The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
Academic Article Distinct polarity cues direct Taz/Yap and TGFß receptor localization to differentially control TGFß-induced Smad signaling.
Academic Article The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7.
Academic Article Switch enhancers interpret TGF-ß and Hippo signaling to control cell fate in human embryonic stem cells.
Academic Article TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression.
Academic Article Systematic morphological profiling of human gene and allele function via Cell Painting.
Academic Article The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.
Academic Article Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.
Academic Article Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis.
Academic Article Integrin-FAK-CDC42-PP1A signaling gnaws at YAP/TAZ activity to control incisor stem cells.
Academic Article Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.
Academic Article Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells.
Academic Article Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation.
Academic Article Functional and genomic analyses reveal therapeutic potential of targeting ß-catenin/CBP activity in head and neck cancer.
Academic Article Phosphatidic Acid Signals via the Hippo Pathway.
Academic Article Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells.

Search Criteria
  • Hippo
  • pathway
  • signaling