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Search Results to G. Graham Shipley, PhD

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Research Expertise & Professional Interests Dr. Shipley is Emeritus Professor of Physiology and Biophysics at Boston University School of Medicine. His research interests center around the structure and function of cell membranes, receptor-ligand interactions and transmembrane signaling mechanisms. A combination of biochemical, chemical and biophysical approaches are used to probe: (1) membrane lipid conformation, structure, properties and interactions, (2) membrane receptor-lipid interactions and (3) membrane receptor-ligand interactions. Current approaches involve the isolation of membrane-associated proteins and lipids (e.g. low density lipoprotein (LDL) receptor, insulin receptor, integrins, gangliosides), their reconstitution with well characterized lipid monolayer and bilayer matrices and structural studies of the protein-lipid assemblies. Ligand binding studes include LDL receptor/LDL, insulin receptor/insulin, and ganglioside/toxin interactions. The biochemical methods involved include lipid and protein isolation, gel/affinity chromatography, antibody techniques, immunoblotting, detergent solubilization, lipid-protein reconstitution, etc. Chemical methods include lipid sythesis, TLC, HPLC, IR and NMR. The biophysical approach involves x-ray diffraction, protein crystallography, electron microscopy/image reconstruction, surface chemistry and calorimetric and spectroscopic (CD, NMR) methods.

One or more keywords matched the following items that are connected to Shipley, G.

Item TypeName
Concept Drug Interactions
Concept Lipid Bilayers
Concept Lipids
Concept Membrane Lipids
Concept Membrane Proteins
Concept Myelin Proteins
Concept Protein Binding
Concept Protein Conformation
Concept Protein Denaturation
Concept Protein Kinase C
Concept Proteins
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Protein Folding
Concept Escherichia coli Proteins
Concept Lipid Metabolism
Academic Article The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid.
Academic Article The three-dimensional crystal structure of cholera toxin.
Academic Article Orientation of cholera toxin bound to model membranes.
Academic Article Structure and thermotropic properties of 1-stearoyl-2-acetyl-phosphatidylcholine bilayer membranes.
Academic Article Structural and thermotropic properties of synthetic C16:0 (palmitoyl) ceramide: effect of hydration.
Academic Article Physical properties of ceramides: effect of fatty acid hydroxylation.
Academic Article X-ray diffraction and calorimetric study of N-lignoceryl sphingomyelin membranes.
Academic Article N-palmitoyl sphingomyelin bilayers: structure and interactions with cholesterol and dipalmitoylphosphatidylcholine.
Academic Article Properties of ganglioside GM1 in phosphatidylcholine bilayer membranes.
Academic Article Structure and interactions of ether- and ester-linked phosphatidylethanolamines.
Academic Article Apoprotein stability and lipid-protein interactions in human plasma high density lipoproteins.
Academic Article Interactions of N-stearoyl sphingomyelin with cholesterol and dipalmitoylphosphatidylcholine in bilayer membranes.
Academic Article Structure and thermotropic properties of hydrated N-stearoyl sphingomyelin bilayer membranes.
Academic Article Structural studies of detergent-solubilized and vesicle-reconstituted low-density lipoprotein (LDL) receptor.
Academic Article Temperature-dependent 13C nuclear magnetic resonance studies of human serum low density lipoproteins.
Academic Article Structure and interactions of lipids in human plasma low density lipoproteins.
Academic Article Thermal behavior of human plasma high density lipoprotein.
Academic Article Structure and thermodynamic properties of high density lipoprotein recombinants.
Academic Article Interactions of cholesterol esters with phospholipids: cholesteryl myristate and dimyristoyl lecithin.
Academic Article Structure and properties of totally synthetic galacto- and gluco-cerebrosides.
Academic Article The phase behavior of hydrated cholesterol.
Academic Article Bilayer properties of totally synthetic C16:0-lactosyl-ceramide.
Academic Article Structural studies of the detergent-solubilized and vesicle-reconstituted insulin receptor.
Academic Article Protein-lipid interactions: recombinants of the proteolipid apoprotein of myelin with dimyristoyllecithin.
Academic Article Molecular interactions between lecithin and sphingomyelin. Temperature- and composition-dependent phase separation.
Academic Article Unusual hydration properties of C16:0 sulfatide bilayer membranes.
Academic Article Localization of the N-terminal domain of the low density lipoprotein receptor.
Academic Article Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques.
Academic Article Bilayers and nonbilayers: structure, forces and protein crystallization.
Academic Article Hydrocarbon chain packing modes in lipids: effect of altered sub-cell dimensions and chain rotation.
Academic Article Structural studies of the lipid components of bile.
Academic Article Structure and properties of mixed-chain phosphatidylcholine bilayers.
Academic Article Interactions of metal ions with phosphatidylserine bilayer membranes: effect of hydrocarbon chain unsaturation.
Academic Article Effect of chain unsaturation on the structure and thermotropic properties of galactocerebrosides.
Academic Article Structural effects of myelin proteolipid apoprotein on phospholipids: a Raman spectroscopic study.
Academic Article Crystallization and preliminary x-ray diffraction study of cholera toxin B-subunit.
Academic Article Effect of chain-linkage on the structure of phosphatidyl choline bilayers. Hydration studies of 1-hexadecyl 2-palmitoyl-sn-glycero-3-phosphocholine.
Academic Article Characterization of the L lambda phase in trehalose-stabilized dry membranes by solid-state NMR and X-ray diffraction.
Academic Article Gel phase polymorphism in ether-linked dihexadecylphosphatidylcholine bilayers.
Academic Article Bilayer interactions of ether- and ester-linked phospholipids: dihexadecyl- and dipalmitoylphosphatidylcholines.
Academic Article Regulation of bilayer stability in Clostridium butyricum: studies on the polymorphic phase behavior of the ether lipids.
Academic Article Partial synthesis and properties of a series of N-acyl sphingomyelins.
Academic Article Mixed-chain phosphatidylcholine bilayers: structure and properties.
Academic Article Thermal and structural behavior of natural cerebroside 3-sulfate in bilayer membranes.
Academic Article Comparative structural aspects of cation binding to phosphatidylserine bilayers.
Academic Article Structural investigations of lipid, polypeptide and protein multilayers.
Academic Article Physical-chemical basis of lipid deposition in atherosclerosis.
Academic Article Phase behavior and structure of aqueous dispersions of sphingomyelin.
Academic Article The effects of temperature on the composition and physical properties of the lipids of Pseudomonas fluorescens.
Academic Article Crystallization of phosphatidylserine bilayers induced by lithium.
Academic Article Structure and thermotropic properties of phosphatidylethanolamine and its N-methyl derivatives.
Academic Article Interaction of cholesterol with galactocerebroside and galactocerebroside-phosphatidylcholine bilayer membranes.
Academic Article Interaction of cholera toxin with ganglioside GM1 receptors in supported lipid monolayers.
Academic Article Magnetic orientation of sphingomyelin-lecithin bilayers.
Academic Article Structure and metastability of N-lignocerylgalactosylsphingosine (cerebroside) bilayers.
Academic Article X-ray scattering of vesicles of N-acyl sphingomyelins. Determination of bilayer thickness.
Academic Article Structure and thermotropic properties of hydrated 1-eicosyl-2-dodecyl-rac-glycero-3-phosphocholine and 1-dodecyl-2-eicosyl-rac-glycero-3-phosphocholine bilayer membranes.
Academic Article Small-angle x-ray scattering studies of cytochrome c-phospholipid complexes.
Academic Article Conformational and thermodynamic properties of apo A-1 of human plasma high density lipoproteins.
Academic Article Galactocerebroside-phospholipid interactions in bilayer membranes.
Academic Article Interactions of divalent cations with phosphatidylserine bilayer membranes.
Academic Article Structural studies of plasma lipoproteins.
Academic Article Interactions of monovalent cations with phosphatidylserine bilayer membranes.
Academic Article Structure and thermotropic behavior of phosphatidylserine bilayer membranes.
Academic Article Evidence for metastability in stearoylsphingomyelin bilayers.
Academic Article Circular dichroic studies of protein kinase C and its interactions with calcium and lipid vesicles.
Academic Article Molecular interactions of ether-linked phospholipids.
Grant Glycosphingolipids and GM1-Cholera Toxin Interactions
Academic Article Atherosclerosis IV: Proceedings of the Fourth International Symposium
Academic Article Liquid Crystals and Ordered Fluids: Volume 2
Academic Article Control of bilayer stability in Clostridium butyricum: phase behavior of the ether lipids

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