Search Results to Kevan L. Hartshorn, MD

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Research Expertise & Professional Interests I am a Medical Oncologist Boston University Medical Center with principle focus on solid tumors. I am Director of the Hematology/Oncology Fellowship program at Boston University School of Medicine for 18 years and also on-site PI for multicenter clinical trials of chemotherapy and targeted agents for various cancers. I participates in cooperative clinical trials groups (NSABP, SWOG, Alliance, and AIDs Clinical Trials group) and to a lesser extent in industry related clinical trials. I did my clinical training in Internal Medicine at Boston City Hospital and then did Fellowship training in Hematology/Oncology at Massachusetts General Hospital. After this I joined the Attending staff at Boston City Hospital and feel very devoted to the mission of Boston Medical Center (the name of the Hospital formed by the merger of Boston City Hospital and Boston University Hospital). This mission is to provide, “Exceptional Care Without Exception”. Boston Medical Center is the main safety net hospital for the city of Boston and prides itself on providing cutting edge care to patient’s regardless or economic or social status. The hospital cares for a large population of African American and immigrant patients and has developed a number of special services (e.g. care navigators) to under-served patients get the care they need. In addition to the above clinical research interests, I have a particular interest in Geriatric Oncology and shared in developing a clinical Fellowship in Geriatric Oncology here which has now been in existence for about 10 years. I have a long standing interest in health care disparities as well. I have mentored numerous Fellows, Medical Students, Residents and College and High School students over the years in clinical care, clinical research and basic research. In addition to my clinical interests have a laboratory research program related to innate immunology have had continuous NIH grant support for 30 years. Our research principally deals with innate immunity, which refers to immune responses that are hard-wired into the genome and provide a first line of protection against infection or transformed cells. Innate immune responses are sometimes also responsible for damaging inflammation. Defects or variants in innate immunity account for increased propensity for infections or harmful inflammation. As an example, people lacking one of the collectins found in blood are at greater risk for infection during neutropenia and have a greater risk for certain cancers. There is surprising complexity and specificity to innate immunity despite the fact that it provides protection even when a person has not been exposed to a specific infection. The main aspects of innate immunity we study include neutrophils and monocyte/macrophages, toll like receptors, and soluble immune defense proteins called collectins and defensins. We study how neutrophils and monocytes become activated in response to infectious organisms (viruses and bacteria), including studies of cell signaling, phagocytosis and oxidant production. We study how defensins and collectins kill bacteria or viruses and promote their uptake by neutrophils and monocytes. We have created or collaborate to create and test a variety of new recombinant versions of collectins and defensins, some of which have strongly increased antiviral or antibacterial activity. We also collaborate with members of the department of Biophysics in crystallographic studies of collectin structure in order to predict protein changes that might confer greater antimicrobial activity. We also collaborate in use of mouse models (e.g., mice in which collectin genes are deleted) to study the role of specific innate immune mediators in infection. A particular area of interest for us is the innate immune response to respiratory infection, especially influenza virus infection. Influenza virus and HIV (which we also study to some extent) are important examples of infections for which innate immunity is important since these viruses undergo continuous mutation thus evading adaptive immune responses (i.e., specific T and B cell responses).

One or more keywords matched the following items that are connected to Hartshorn, Kevan

Item TypeName
Concept Immunosenescence
Concept Acquired Immunodeficiency Syndrome
Concept Cytotoxicity, Immunologic
Concept Enzyme-Linked Immunosorbent Assay
Concept Immunoglobulin G
Concept Immunoenzyme Techniques
Concept Immunoglobulin Fragments
Concept Immunoglobulins
Concept Immunoglobulin Fab Fragments
Concept Immunohistochemistry
Concept Immunologic Factors
Concept Immunosuppressive Agents
Concept Immunotherapy
Concept Receptors, Immunologic
Concept Immunophenotyping
Concept Immunoprecipitation
Concept Sialic Acid Binding Immunoglobulin-like Lectins
Academic Article Bovine conglutinin gene exon structure reveals its evolutionary relationship to surfactant protein-D.
Academic Article Conglutinin acts as an opsonin for influenza A viruses.
Academic Article Neutrophil deactivation by influenza A viruses: mechanisms of protection after viral opsonization with collectins and hemagglutination-inhibiting antibodies.
Academic Article Collectins and pulmonary innate immunity.
Academic Article Enhanced antiviral and opsonic activity of a human mannose-binding lectin and surfactant protein D chimera.
Academic Article Anomalous features of human neutrophil activation by influenza A virus are shared by related viruses and sialic acid-binding lectins.
Academic Article Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection.
Academic Article Surfactant protein D enhances clearance of influenza A virus from the lung in vivo.
Academic Article Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein.
Academic Article Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses.
Academic Article Porcine pulmonary collectins show distinct interactions with influenza A viruses: role of the N-linked oligosaccharides in the carbohydrate recognition domain.
Academic Article Effective targeting of pathogens to neutrophils via chimeric surfactant protein D/anti-CD89 protein.
Academic Article Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor.
Academic Article Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus.
Academic Article Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication.
Academic Article A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D.
Academic Article Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation.
Academic Article Influenza a viruses upregulate neutrophil toll-like receptor 2 expression and function.
Academic Article Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D.
Academic Article Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D.
Academic Article Inhibition of hemagglutination activity of influenza A viruses by SP-A1 and SP-A2 variants expressed in CHO cells.
Academic Article Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses.
Academic Article Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection.
Academic Article Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus.
Academic Article Multiple components contribute to ability of saliva to inhibit influenza viruses.
Academic Article Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.
Academic Article Innate immunity to influenza virus: implications for future therapy.
Academic Article Role of surfactant protein A and D (SP-A and SP-D) in human antiviral host defense.
Academic Article Increasing antiviral activity of surfactant protein d trimers by introducing residues from bovine serum collectins: dissociation of mannan-binding and antiviral activity.
Academic Article Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection.
Academic Article Enhancement of antiviral activity of collectin trimers through cross-linking and mutagenesis of the carbohydrate recognition domain.
Academic Article Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity.
Academic Article Innate immune response to influenza A virus in differentiated human alveolar type II cells.
Academic Article Hapivirins and diprovirins: novel ?-defensin analogs with potent activity against influenza A virus.
Academic Article Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses.
Academic Article Innate immune response of human alveolar macrophages during influenza A infection.
Academic Article FABP5 deficiency enhances susceptibility to H1N1 influenza A virus-induced lung inflammation.
Academic Article Detection of human T-cell lymphotropic virus type III-related antigens and anti-human T-cell lymphotropic virus type III antibodies by anticomplementary immunofluorescence.
Academic Article Priming of human neutrophils with N-formyl-methionyl-leucyl-phenylalanine by a calcium-independent, pertussis toxin-insensitive pathway.
Academic Article Activity of interferons alpha, beta, and gamma against human immunodeficiency virus replication in vitro.
Academic Article Effects of influenza A virus on human neutrophil calcium metabolism.
Academic Article Dot immunobinding assay for detection of human immunodeficiency virus-associated antigens.
Academic Article Therapeutic perspectives in human immunodeficiency virus infection.
Academic Article Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.
Academic Article Antibody-dependent cell-mediated cytotoxicity against cells infected with the human immunodeficiency virus.
Academic Article Partial purification and identification of an immunosuppressive factor in AIDS sera.
Academic Article Neutrophil deactivation by influenza A virus. Role of hemagglutinin binding to specific sialic acid-bearing cellular proteins.
Academic Article Does a personal or family history of malignancy preclude the use of immunomodulators and biologics in IBD.
Academic Article Efficacy of recombinant chimeric lectins, consisting of mannose binding lectin and L-ficolin, against influenza A viral infection in mouse model study.
Academic Article The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy.
Academic Article Immunotherapy comes of age: Immune aging & checkpoint inhibitors.
Academic Article Immunological Reviews
Academic Article The Role and Molecular Mechanism of Action of Surfactant Protein D in Innate Host Defense Against Influenza A Virus.
Academic Article Aging,?immune senescence,?and immunotherapy:?A comprehensive review.
Academic Article Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain.
Grant Development of Novel Immunotherapy for Influenza Virus Infection

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