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Search Results to Kevan L. Hartshorn, MD

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Research Expertise & Professional Interests I am a Medical Oncologist Boston University Medical Center with principle focus on solid tumors. I am Director of the Hematology/Oncology Fellowship program at Boston University School of Medicine for 18 years and also on-site PI for multicenter clinical trials of chemotherapy and targeted agents for various cancers. I participates in cooperative clinical trials groups (NSABP, SWOG, Alliance, and AIDs Clinical Trials group) and to a lesser extent in industry related clinical trials. I did my clinical training in Internal Medicine at Boston City Hospital and then did Fellowship training in Hematology/Oncology at Massachusetts General Hospital. After this I joined the Attending staff at Boston City Hospital and feel very devoted to the mission of Boston Medical Center (the name of the Hospital formed by the merger of Boston City Hospital and Boston University Hospital). This mission is to provide, “Exceptional Care Without Exception”. Boston Medical Center is the main safety net hospital for the city of Boston and prides itself on providing cutting edge care to patient’s regardless or economic or social status. The hospital cares for a large population of African American and immigrant patients and has developed a number of special services (e.g. care navigators) to under-served patients get the care they need. In addition to the above clinical research interests, I have a particular interest in Geriatric Oncology and shared in developing a clinical Fellowship in Geriatric Oncology here which has now been in existence for about 10 years. I have a long standing interest in health care disparities as well. I have mentored numerous Fellows, Medical Students, Residents and College and High School students over the years in clinical care, clinical research and basic research. In addition to my clinical interests have a laboratory research program related to innate immunology have had continuous NIH grant support for 30 years. Our research principally deals with innate immunity, which refers to immune responses that are hard-wired into the genome and provide a first line of protection against infection or transformed cells. Innate immune responses are sometimes also responsible for damaging inflammation. Defects or variants in innate immunity account for increased propensity for infections or harmful inflammation. As an example, people lacking one of the collectins found in blood are at greater risk for infection during neutropenia and have a greater risk for certain cancers. There is surprising complexity and specificity to innate immunity despite the fact that it provides protection even when a person has not been exposed to a specific infection. The main aspects of innate immunity we study include neutrophils and monocyte/macrophages, toll like receptors, and soluble immune defense proteins called collectins and defensins. We study how neutrophils and monocytes become activated in response to infectious organisms (viruses and bacteria), including studies of cell signaling, phagocytosis and oxidant production. We study how defensins and collectins kill bacteria or viruses and promote their uptake by neutrophils and monocytes. We have created or collaborate to create and test a variety of new recombinant versions of collectins and defensins, some of which have strongly increased antiviral or antibacterial activity. We also collaborate with members of the department of Biophysics in crystallographic studies of collectin structure in order to predict protein changes that might confer greater antimicrobial activity. We also collaborate in use of mouse models (e.g., mice in which collectin genes are deleted) to study the role of specific innate immune mediators in infection. A particular area of interest for us is the innate immune response to respiratory infection, especially influenza virus infection. Influenza virus and HIV (which we also study to some extent) are important examples of infections for which innate immunity is important since these viruses undergo continuous mutation thus evading adaptive immune responses (i.e., specific T and B cell responses).

One or more keywords matched the following items that are connected to Hartshorn, Kevan

Item TypeName
Concept Influenza A virus
Concept Influenza B virus
Concept Parainfluenza Virus 1, Human
Concept Receptors, Virus
Concept Virus Activation
Concept Virus Cultivation
Concept Virus Diseases
Concept Virus Replication
Concept Virus Physiological Phenomena
Concept Hemagglutinin Glycoproteins, Influenza Virus
Concept Virus Inactivation
Concept Influenza A Virus, H1N1 Subtype
Concept Influenza A Virus, H3N2 Subtype
Concept Influenza A Virus, H3N8 Subtype
Concept Influenza A Virus, H5N1 Subtype
Concept Virus Internalization
Academic Article Interferon-alpha enhances neutrophil respiratory burst responses to stimulation with influenza A virus and FMLP.
Academic Article Human neutrophil respiratory burst response to influenza A virus occurs at an intracellular location.
Academic Article Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses.
Academic Article Conglutinin acts as an opsonin for influenza A viruses.
Academic Article Site-directed mutagenesis of Cys-15 and Cys-20 of pulmonary surfactant protein D. Expression of a trimeric protein with altered anti-viral properties.
Academic Article Interactions of recombinant human pulmonary surfactant protein D and SP-D multimers with influenza A.
Academic Article Neutrophil deactivation by influenza A viruses: mechanisms of protection after viral opsonization with collectins and hemagglutination-inhibiting antibodies.
Academic Article Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria.
Academic Article Influenza A virus up-regulates neutrophil adhesion molecules and adhesion to biological surfaces.
Academic Article Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins.
Academic Article Collectins and pulmonary innate immunity.
Academic Article Enhanced antiviral and opsonic activity of a human mannose-binding lectin and surfactant protein D chimera.
Academic Article Neutrophil survival is markedly reduced by incubation with influenza virus and Streptococcus pneumoniae: role of respiratory burst.
Academic Article Prophylaxis and treatment of influenza virus infection.
Academic Article Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein.
Academic Article Development of chimeric collectins with enhanced activity against influenza A virus.
Academic Article Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutinin to antiviral activity.
Academic Article Increased antiviral and opsonic activity of a highly multimerized collectin chimera.
Academic Article Comparison of influenza A virus and formyl-methionyl-leucyl-phenylalanine activation of the human neutrophil.
Academic Article Anomalous features of human neutrophil activation by influenza A virus are shared by related viruses and sialic acid-binding lectins.
Academic Article Distinctive anti-influenza properties of recombinant collectin 43.
Academic Article Influenza A virus binding to human neutrophils and cross-linking requirements for activation.
Academic Article Role of the respiratory burst in co-operative reduction in neutrophil survival by influenza A virus and Escherichia coli.
Academic Article Porcine surfactant protein D is N-glycosylated in its carbohydrate recognition domain and is assembled into differently charged oligomers.
Academic Article Surfactant protein D enhances clearance of influenza A virus from the lung in vivo.
Academic Article Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein.
Academic Article Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses.
Academic Article Porcine pulmonary collectins show distinct interactions with influenza A viruses: role of the N-linked oligosaccharides in the carbohydrate recognition domain.
Academic Article Effective targeting of pathogens to neutrophils via chimeric surfactant protein D/anti-CD89 protein.
Academic Article Interactions of influenza A virus with sialic acids present on porcine surfactant protein D.
Academic Article Cooperative anti-influenza activities of respiratory innate immune proteins and neuraminidase inhibitor.
Academic Article Ligand specificity of human surfactant protein D: expression of a mutant trimeric collectin that shows enhanced interactions with influenza A virus.
Academic Article Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus.
Academic Article Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication.
Academic Article A common polymorphism in the SFTPD gene influences assembly, function, and concentration of surfactant protein D.
Academic Article Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation.
Academic Article Influenza a viruses upregulate neutrophil toll-like receptor 2 expression and function.
Academic Article Innate defense against influenza A virus: activity of human neutrophil defensins and interactions of defensins with surfactant protein D.
Academic Article Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D.
Academic Article Species differences in the carbohydrate binding preferences of surfactant protein D.
Academic Article Human neutrophil stimulation by influenza virus: relationship of cytoplasmic pH changes to cell activation.
Academic Article Inhibition of influenza viral neuraminidase activity by collectins.
Academic Article Impact of neutrophils on antiviral activity of human bronchoalveolar lavage fluid.
Academic Article Characterization of influenza A virus activation of the human neutrophil.
Academic Article Critical role for cross-linking of trimeric lectin domains of surfactant protein D in antiviral activity against influenza A virus.
Academic Article Inhibition of hemagglutination activity of influenza A viruses by SP-A1 and SP-A2 variants expressed in CHO cells.
Academic Article Human neutrophil defensins increase neutrophil uptake of influenza A virus and bacteria and modify virus-induced respiratory burst responses.
Academic Article Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection.
Academic Article Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343.
Academic Article Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D.
Academic Article Multimerization of surfactant protein D, but not its collagen domain, is required for antiviral and opsonic activities related to influenza virus.
Academic Article Multiple components contribute to ability of saliva to inhibit influenza viruses.
Academic Article Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D.
Academic Article Innate immunity to influenza virus: implications for future therapy.
Academic Article New look at an old problem: bacterial superinfection after influenza.
Academic Article Viral aggregating and opsonizing activity in collectin trimers.
Academic Article Role of surfactant protein A and D (SP-A and SP-D) in human antiviral host defense.
Academic Article Increasing antiviral activity of surfactant protein d trimers by introducing residues from bovine serum collectins: dissociation of mannan-binding and antiviral activity.
Academic Article Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D.
Academic Article Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin.
Academic Article Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection.
Academic Article Enhancement of antiviral activity of collectin trimers through cross-linking and mutagenesis of the carbohydrate recognition domain.
Academic Article Recombinant human interferon alfa-A suppresses HTLV-III replication in vitro.
Academic Article Innate immune response to influenza A virus in differentiated human alveolar type II cells.
Academic Article The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding.
Academic Article Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses.
Academic Article Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection.
Academic Article Synergistic inhibition of human T-cell lymphotropic virus type III replication in vitro by phosphonoformate and recombinant alpha-A interferon.
Academic Article GM-CSF modulates pulmonary resistance to influenza A infection.
Academic Article Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo.
Academic Article Phosphatidylglycerol suppresses influenza A virus infection.
Academic Article Hapivirins and diprovirins: novel ?-defensin analogs with potent activity against influenza A virus.
Academic Article Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus.
Academic Article A unique sugar-binding site mediates the distinct anti-influenza activity of pig surfactant protein D.
Academic Article Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses.
Academic Article Innate immune response of human alveolar macrophages during influenza A infection.
Academic Article Mannose-binding lectin binds to amyloid ß protein and modulates inflammation.
Academic Article High molecular weight constituents of cranberry interfere with influenza virus neuraminidase activity in vitro.
Academic Article The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins.
Academic Article FABP5 deficiency enhances susceptibility to H1N1 influenza A virus-induced lung inflammation.
Academic Article Influenza A virus and the neutrophil: a model of natural immunity.
Academic Article Detection of human T-cell lymphotropic virus type III-related antigens and anti-human T-cell lymphotropic virus type III antibodies by anticomplementary immunofluorescence.
Academic Article Ribavirin antagonizes the effect of azidothymidine on HIV replication.
Academic Article The influenza virus--infected phagocyte. A model of deactivation.
Academic Article Activity of interferons alpha, beta, and gamma against human immunodeficiency virus replication in vitro.
Academic Article Effects of influenza A virus on human neutrophil calcium metabolism.
Academic Article Dot immunobinding assay for detection of human immunodeficiency virus-associated antigens.
Academic Article Therapeutic perspectives in human immunodeficiency virus infection.
Academic Article Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon.
Academic Article Antibody-dependent cell-mediated cytotoxicity against cells infected with the human immunodeficiency virus.
Academic Article Human mannose-binding protein functions as an opsonin for influenza A viruses.
Academic Article Neutrophil deactivation by influenza A virus. Role of hemagglutinin binding to specific sialic acid-bearing cellular proteins.
Academic Article Why does pandemic influenza virus kill?
Academic Article Alzheimer''s associated ß-amyloid protein inhibits influenza A virus and modulates viral interactions with phagocytes.
Academic Article Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis.
Academic Article The amazing innate immune response to influenza A virus infection.
Academic Article Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation.
Academic Article Efficacy of recombinant chimeric lectins, consisting of mannose binding lectin and L-ficolin, against influenza A viral infection in mouse model study.
Academic Article Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses.
Academic Article Recombinant human mannose-binding lectin dampens human alveolar macrophage inflammatory responses to influenza A virus in vitro.
Academic Article Arginine-rich histones have strong antiviral activity for influenza A viruses.
Academic Article LL-37 modulates human neutrophil responses to influenza A virus.
Academic Article Contemporary avian influenza A virus subtype H1, H6, H7, H10, and H15 hemagglutinin genes encode a mammalian virulence factor similar to the 1918 pandemic virus H1 hemagglutinin.
Academic Article Mutations flanking the carbohydrate binding site of surfactant protein D confer antiviral activity for pandemic influenza A viruses.
Academic Article Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production.
Academic Article Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions.
Academic Article The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy.
Academic Article Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection.
Academic Article Critical role of C-terminal residues of the Alzheimer''s associated ß-amyloid protein in mediating antiviral activity and modulating viral and bacterial interactions with neutrophils.
Academic Article Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus.
Academic Article The Role and Molecular Mechanism of Action of Surfactant Protein D in Innate Host Defense Against Influenza A Virus.
Academic Article Influenza Virus Hemagglutinins H2, H5, H6, and H11 Are Not Targets of Pulmonary Surfactant Protein D: N-Glycan Subtypes in Host-Pathogen Interactions.
Grant Development of Novel Immunotherapy for Influenza Virus Infection
Grant Innate Immunity in the Clearance of Influenza A Virus Ifected Apoptotic Cells

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