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Research Expertise & Professional Interests Paola Sebastiani, Ph.D. joined the Department of Biostatistics in 2003 as an Associate Professor, after holding faculty positions in Italy, England and United States. She is author of more than 200 peer-reviewed publications in theoretical and methodological statistics, artificial intelligence, computational biology and genetics. She is statistical consultant for Circulation and also a regular reviewer for major journals in statistics and computer science, and serves on the program committee of several international conferences at the interface between statistics and artificial intelligence. When she joined the Department of Biostatistics at Boston University in 2003, Dr. Sebastiani had experience in interdisciplinary collaborations and a track record of developing novel methodologies in Bayesian statistics, machine learning, decision theory, graphical modeling and statistical experimental design. She leveraged this experience to develop a wide network of collaborations with investigators from the Bioinformatics program, the Genetics and Genomics program, and the Molecular and Translational Medicine Program. In these collaborations Dr. Sebastiani often introduced original solutions by developing innovative Bayesian techniques for the analysis of genomic and genetic data and for the joint modeling of the genetic, genomic and phenotypic basis of complex traits. This work has been supported by the National Science Foundation and the National Institutes for Health and is currently funded by grants of which Dr. Sebastiani is Principal Investigator. Her contributions include, among others, a Bayesian model-based clustering procedure of temporal expression profiles (CAGED), a robust Bayesian approach to analyze differential gene expression using model averaging (BADGE), and novel methods for analysis of genetic data. Dr. Sebastiani was a pioneer in using a Bayesian network approach to model the genetic and phenotypic basis of complications of sickle cell anemia. She developed the first network model for predicting stroke in patients with sickle cell anemia and a network-based prognostic model that integrates sub-phenotypes of sickle cell anemia patients into a score of the overall severity of disease. This model was successfully evaluated by independent investigators and has opened several new research areas in sickle cell disease. These results were the fruit of a long and productive collaboration with Dr. Steinberg to study the genetic basis of different clinical presentations of sickle cell disease. Dr. Sebastiani has also cultivated a strong and growing reputation as a biostatistician in the fields of gerontology, biology and epidemiology of human aging and longevity. She is the primary statistician of the BU site of the Long Life Family Study, and of the New England Centenarian Study directed by Dr. Thomas Perls. Dr. Sebastiani used an original Bayesian approach to verify the “compression of morbidity hypothesis” that had long been debated in the field of gerontology, developed a method for scoring sibships for familial longevity that can be used to enroll the most informative families in observational studies of human longevity, and introduced a novel Bayesian approach to model the genetic and phenotypic basis of exceptional human longevity. The analysis provides evidence that extreme human longevity is not due to absence of disease variants but to rare combinations of large numbers of common protective variants. Her current work focuses on the generation of molecular profiles to predict patterns of aging, and the biology of aging using a system-based approach.
Self-Described Keywords Bayesian Modeling of genetic and genomic data

One or more keywords matched the following items that are connected to Sebastiani, Paola

Item TypeName
Concept Algorithms
Concept Biopsy
Concept Blood Cell Count
Concept Blood Pressure Determination
Concept Bronchoscopy
Concept Chromatography, Thin Layer
Concept Chromosome Mapping
Concept Combined Modality Therapy
Concept Computer Simulation
Concept Cross-Sectional Studies
Concept Data Collection
Concept Demography
Concept DNA Mutational Analysis
Concept Enzyme-Linked Immunosorbent Assay
Concept Family
Concept Family Characteristics
Concept Fourier Analysis
Concept Health Status Indicators
Concept Immobilization
Concept Immunohistochemistry
Concept Leukocyte Count
Concept Longitudinal Studies
Concept Lymphocyte Activation
Concept Magnetic Resonance Imaging
Concept Mastectomy
Concept Mathematical Computing
Concept Models, Theoretical
Concept Magnetic Resonance Spectroscopy
Concept Personality Inventory
Concept Population Surveillance
Concept Prognosis
Concept Prospective Studies
Concept Research Design
Concept Respiratory Function Tests
Concept Statistics as Topic
Concept Triage
Concept Genetic Therapy
Concept Cohort Studies
Concept Case-Control Studies
Concept Human Genome Project
Concept Mammaplasty
Concept Neural Networks (Computer)
Concept Sequence Analysis, DNA
Concept Risk Assessment
Concept Cross-Over Studies
Concept CD4 Lymphocyte Count
Concept Computational Biology
Concept Censuses
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Oligonucleotide Array Sequence Analysis
Concept Gene Expression Profiling
Concept Microarray Analysis
Concept Genome-Wide Association Study
Concept Genetic Association Studies
Concept Opiate Substitution Treatment
Concept Real-Time Polymerase Chain Reaction
Academic Article Robust outcome prediction for intensive-care patients.
Academic Article Minimal haplotype tagging.
Academic Article Bayesian machine learning and its potential applications to the genomic study of oral oncology.
Academic Article A Bayesian dynamic model for influenza surveillance.
Academic Article Building chromosome-wide LD maps.
Academic Article Bayesian estimates of linkage disequilibrium.
Academic Article Fetal hemoglobin in sickle cell anemia: Bayesian modeling of genetic associations.
Academic Article A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
Academic Article Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks.
Academic Article Conditional clustering of temporal expression profiles.
Academic Article Evolution and challenges in the design of computational systems for triage assistance.
Academic Article Imputation of missing genotypes: an empirical evaluation of IMPUTE.
Academic Article A prediction model for lung cancer diagnosis that integrates genomic and clinical features.
Academic Article RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.
Academic Article Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium.
Academic Article Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study.
Academic Article Prediction models that include genetic data.
Academic Article Clustering by genetic ancestry using genome-wide SNP data.
Academic Article Bayesian methods for multivariate modeling of pleiotropic SNP associations and genetic risk prediction.
Academic Article Naïve Bayesian Classifier and Genetic Risk Score for Genetic Risk Prediction of a Categorical Trait: Not so Different after all!
Academic Article Bayesian selection of decomposable models with incomplete data
Academic Article A predictive approach to the Bayesian design problem with application to normal regression models
Academic Article Journal of Multivariate analysis
Academic Article Maximum entropy sampling and optimal Bayesian experimental design
Academic Article Bayesian analysis of comparative microarray experiments by model averaging
Academic Article An efficient technique for Bayesian modeling of family data using the BUGS software.
Academic Article Educating translational researchers in research informatics principles and methods: an evaluation of a model online course and plans for its dissemination.
Academic Article Bayesian Polynomial Regression Models to Fit Multiple Genetic Models for Quantitative Traits.
Academic Article Bayesian polynomial regression models to fit multiple genetic models for quantitative traits
Academic Article Learning Bayesian Networks from Correlated Data.
Academic Article Bayesian Graphical Models for Gene-Environment Interaction. Proceedings of the JSM, 2013
Academic Article Bayesian clustering by dynamics
Academic Article On the use of Bayesian networks to analyze survey data
Academic Article Bayesian inference with missing data using bound and collapse
Academic Article Parameter estimation in Bayesian networks from incomplete databases
Academic Article Experimental designs for mean and variance estimation in variance component models
Academic Article J Amer Statist. Assoc
Academic Article Problem Solving Handbook in Computational Biology and Bioinformatics (L. S. Heath, N. Ramakrishnan, eds.)
Academic Article Problem Solving Handbook in Computational Biology and Bioinformatics ( L. S. Heath, N. Ramakrishnan, eds.)
Academic Article Bayesian Belief Networks: A Practical Guide to Applications (O. Pourret, P. Nam and B. G. Marcot, eds.)
Academic Article Systems Bioinformatics: An Engineering Case-Based Approach (G Alterowitz and M. F. Ramoni, eds.)
Academic Article Encyclopedia of Data Warehousing and Mining
Academic Article The Data Mining and Knowledge Discovery Handbook
Academic Article Genomic Signal Processing and Statistics (Dougherty, E. R., Shmulevich, I., Chen, J., Wang, Z. J., Eds.)
Academic Article Intelligent Data Analysis. An Introduction (M. R. Berthold, D.J. Hand, eds.)
Academic Article The Analysis of Gene Expression Data: Methods and Software, (Parmigiani, G., Garrett, E. S., Irizarry, R., and Zeger, S., eds.)
Academic Article Sequence Learning: Paradigms, Algorithms, and Applications (L. Giles, R. Sun, eds.)
Academic Article Lecture Notes in Computer Science: Advances in Intelligent Data Analysis XI
Academic Article Lecture Notes in Computer Science: 6th International Conference on Practical Applications of Computational Biology and Bioinformatics
Academic Article Lecture Notes in Computer Science: Proceedings of Computation and Simulation in Modelling Biological Systems
Academic Article 19th IEEE Symposium on Computer-Based Medical Systems (CBMS’06)
Academic Article Lecture Notes in Computer Science: Research in Computational Molecular Biology: 10th Annual International Conference, (RECOMB 2006)
Academic Article Lecture Notes in Computer Science: Modeling Decisions for Artificial Intelligence: 3rd International Conference, (MDAI 2006)
Academic Article New Developments in Classification and Data Analysis
Academic Article Book of short papers. CLADAG 2003: Meeting of the Classification and Data Analysis Group of the Italian Statistical Society
Academic Article Lecture Notes in Computer Science: Proceedings of the Fifth International Symposium on Intelligent Data Analysis
Academic Article Proceedings of the 2nd International Conference on Development and Learning
Academic Article Bayesian Methods: Selected Papers from Sixth World Meeting of the International Society for Bayesian Analysis (ISBA)
Academic Article Bayesian Methods: Selected Papers from Sixth World Meeting of the International Society for Bayesian Analysis (ISBA)
Academic Article MaxEnt 2000: Twentieth International Workshop on Bayesian Inference and Maximum Entropy in Science and Engineering
Academic Article MaxEnt 2000: Twentieth International Workshop on Bayesian Inference and Maximum Entropy in Science and Engineering
Academic Article Proceedings of the 5th Workshop on Case Studies in Bayesian Statistics
Academic Article Proceeding of the National Conference of the American Association for Artificial Intelligence (AAAI-2000)
Academic Article Proceedings of the 14th Conference for Statistical Computing (Compstat 2000). Short Papers
Academic Article Proceedings of the 4th International Conference on Autonomous Agents (Agents 2000)
Academic Article Proceedings of the 3rd International Symposium on Intelligent Data Analysis
Academic Article Proceedings of International Joint Conference in Artificial Intelligence Workshop on Neural, Symbolic and Reinforcement Methods for Sequence Learning
Academic Article Proceedings of the 13th Conference for Statistical Computing (Compstat98)
Academic Article Proceedings of the 2nd International Symposium on Intelligent Data Analysis
Academic Article Proceedings of the 13th Conference on Uncertainty in Artificial Intelligence
Academic Article Bayesian Statistics 5
Academic Article Manual and Automated Procedures for Compiling a Very Large Sample of Centenarian Pedigrees
Academic Article PopCluster: an algorithm to identify genetic variants with ethnicity-dependent effects.
Academic Article CaDrA: A Computational Framework for Performing Candidate Driver Analyses Using Genomic Features.

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  • Bayesian
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  • Computing
  • Algorithms