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Search Results to Byungwoo Ryu, PhD

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Research Expertise & Professional Interests Dr. Ryu joined the Department of Dermatology at the Boston University of School of Medicine as an assistant Professor in 2011. He received his Ph.D. degree from Oregon State University in Molecular Toxicology. Dr. Ryu completed his postdoctoral fellowships at the National Cancer Institute in Bethesda, Maryland and Sidney Kimmel Comprehensive Cancer Center at the Johns Hopkins University School of Medicine, Baltimore, Maryland. Dr. Ryu served as an assistant member of the Nevada Cancer Institute at Las Vegas, Nevada and clinical assistant professor of medicine at the University of Nevada School of Medicine at Reno, Nevada. Dr. Ryu is a recipient of Howard Temin Award, career development award (K01), from the National Cancer Institute. Dr. Ryu’s research interest is to determine the molecular events that dictate melanoma tumorigenicity and malignant progression. It is likely that identification of such molecular pathways will allow us to identify clinically useful biomarkers as well as potential therapeutic targets against this lethal form of skin cancer. Biomarkers for melanoma progression: Dr. Ryu’s laboratory currently focuses on discovery of molecular biomarkers that can be used for patient stratification and personalized therapy. His laboratory uses genomic and molecular profiling techniques on tissue and blood samples from melanoma patients to find patterns of molecular signatures and correlate them with clinical outcomes. Therapeutic targeting of metastasis-initiating cells (MICs): Despite recent progress, the molecular mechanisms of tumor metastasis remain unclear. Isolation and dissection of the MICs, subpopulation of tumor cells including circulating cancer cells in patient’s blood, will shed light on the molecular events of metastasis progression. Dr. Ryu’s laboratory focuses on the genetic and epigenetic characterization of the MICs as well as developing therapeutic and preventive strategies of cancer metastasis by targeting the MICs.
Self-Described Keywords Therapeutic target discovery
Self-Described Keywords Epigenetics

One or more keywords matched the following items that are connected to Ryu, Byungwoo

Item TypeName
Concept Breast Neoplasms
Concept Neoplasms
Concept Neoplasms, Experimental
Concept Pancreatic Neoplasms
Concept Prostatic Neoplasms
Concept Skin Neoplasms
Academic Article High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells.
Academic Article A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.
Academic Article Frequent germline deletion polymorphism of chromosomal region 8p12-p21 identified as a recurrent homozygous deletion in human tumors.
Academic Article Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers.
Academic Article Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma.
Academic Article Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE).
Academic Article Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.
Academic Article The essential similarity of TGFbeta and activin receptor transcriptional responses in cancer cells.
Academic Article Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion.
Academic Article Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression.
Academic Article Id proteins in cell growth and tumorigenesis.
Academic Article Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors.
Academic Article Id1 expression is transcriptionally regulated in radial growth phase melanomas.
Academic Article Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction.
Academic Article Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas.
Academic Article MicroRNAs as an emerging target for melanoma therapy.
Academic Article Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells.
Academic Article Neuropilin-2 gene expression correlates with malignant progression in cutaneous melanoma.
Academic Article Epigenetic Silencing of SPINT2 Promotes Cancer Cell Motility via HGF-MET Pathway Activation in Melanoma.
Academic Article Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.
Grant Epigenetic detection and chemoprevention of skin cancer

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  • Epigenetic
  • therapies
  • cancer