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Search Results to James E. Galagan, PhD

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One or more keywords matched the following properties of Galagan, James

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Research Expertise & Professional Interests Dr. Galagan’s research is focused on Systems Biology of microbial organisms, specficially Mycobacterium tuberculosis – the causative agent of tuberculosis – and the fungus Neurospora crassa. The Galagan Lab is an interdisciplinary group that combines computational biology, genomics, and experimental lab work. Specific interests and projects include: • Using a genomics, computational modeling, and experimental systems-identification techniques to reconstruct the gene regulatory network of M. tuberculosis. • Developing and experimentally validating computational models of microbial metabolism for M. tuberculosis and N. crassa. • Using high-throughput sequencing and comparative sequence analysis to study the functional evolution of M. tuberculosis. • Developing computational methods for genomic data analysis (including gene prediction, gene expression analysis, and polymorphism discovery) • Developing experimental methods for microbial systems identification and analysis, drawing on electrical and mechanical systems identification methods
Self-Described Keywords Tuberculosis

One or more keywords matched the following items that are connected to Galagan, James

Item TypeName
Concept Mycobacterium tuberculosis
Concept Tuberculosis, Multidrug-Resistant
Concept Latent Tuberculosis
Academic Article TB database: an integrated platform for tuberculosis research.
Academic Article Interpreting expression data with metabolic flux models: predicting Mycobacterium tuberculosis mycolic acid production.
Academic Article A blind deconvolution approach to high-resolution mapping of transcription factor binding sites from ChIP-seq data.
Academic Article TB database 2010: overview and update.
Academic Article Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved.
Academic Article Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection.
Academic Article Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region.
Academic Article Comparative analysis of Mycobacterium and related Actinomycetes yields insight into the evolution of Mycobacterium tuberculosis pathogenesis.
Academic Article Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.
Academic Article ChIP-Seq and the complexity of bacterial transcriptional regulation.
Academic Article The role of selection in shaping diversity of natural M. tuberculosis populations.
Academic Article The Mycobacterium tuberculosis regulatory network and hypoxia.
Academic Article Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis.
Academic Article The DNA-binding network of Mycobacterium tuberculosis.
Academic Article Transcription Factor Binding Site Mapping Using ChIP-Seq.
Academic Article Genomic insights into tuberculosis.
Academic Article Comprehensive Definition of the SigH Regulon of Mycobacterium tuberculosis Reveals Transcriptional Control of Diverse Stress Responses.
Academic Article Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value.
Academic Article Characterization of a cAMP responsive transcription factor, Cmr (Rv1675c), in TB complex mycobacteria reveals overlap with the DosR (DevR) dormancy regulon.
Academic Article Metabolic modeling predicts metabolite changes in Mycobacterium tuberculosis.
Academic Article Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance.
Academic Article Mycobacterium tuberculosis Whole Genome Sequences From Southern India Suggest Novel Resistance Mechanisms and the Need for Region-Specific Diagnostics.
Grant Predictive modeling of the Mycobacterium tuberculosis regulatory and metabolic networks

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  • Tuberculosis