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Search Results to Olga Gursky, PhD

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Research Expertise & Professional Interests Our research focus is on protein folding, structure and stability. It includes the analysis of the energetic-structure-function relationship and folding pathways in proteins and peptides by circular dichroism spectroscopy, differential scanning calorimetry, fluorescence, x-ray crystallography, and site-directed mutagenesis. Our on-going NIH-funded work is aimed at understanding the energetic and structural basis for the conformational plasticity of apolipoproteins. These are protein constituents of lipoproteins that mediate lipid transport and metabolism and are central in the pathogenesis of atherosclerosis, stroke, and certain forms of amyloidosis. Apolipoproteins are distinct in their structural adaptability to various lipoprotein particles and to plasma. We try to understand in molecular detail the energetic and structural basis for this adaptability. A major focus of our research is on the molecular mechanisms of lipoprotein stabilization and fusion. In 2002 we revealed that lipoprotein stability is determined by kinetic barriers. Similar barriers may modulate in-vivo lipoprotein transformations. Our goal is to obtain key molecular determinants for these energy barriers.
Self-Described Keywords protein spectroscopy
Self-Described Keywords structural biology and spectroscopy

One or more keywords matched the following items that are connected to Gursky, Olga

Item TypeName
Academic Article Structural studies of N- and C-terminally truncated human apolipoprotein A-I.
Academic Article Structural basis for thermal stability of human low-density lipoprotein.
Academic Article Correlation of structural stability with functional remodeling of high-density lipoproteins: the importance of being disordered.
Academic Article Effects of oxidation on structural stability and remodeling of human very low density lipoprotein.
Academic Article Effects of phospholipase A(2) and its products on structural stability of human LDL: relevance to formation of LDL-derived lipid droplets.
Academic Article Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I.
Academic Article Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights.
Academic Article Structural stability and functional remodeling of high-density lipoproteins.
Academic Article Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?
Academic Article Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?
Grant Structural Thermodynamics of Human Apolipoprotein C-1
Grant Structural Thermodynamics of Human Apolipoprotein C-1
Academic Article Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens.
Academic Article Effects of triacylglycerol on the structural remodeling of human plasma very low- and low-density lipoproteins.
Academic Article Circular Dichroism: Theory and Spectroscopy, D.S. Rogers, Edt. Nova Publishers pp. 175-215
Academic Article Advances in Experimental Medicine and Biology, 855
Academic Article Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A.
Academic Article Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia.
Academic Article Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve.
Grant Structural Stability and Functional Remodeling of High-density Lipoproteins
Grant Structural Stability and Functional Remodeling of High-density Lipoproteins

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  • biology
  • spectroscopy