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Search Results to Olga Gursky, PhD

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Research Expertise & Professional Interests Our research focus is on protein folding, structure and stability. It includes the analysis of the energetic-structure-function relationship and folding pathways in proteins and peptides by circular dichroism spectroscopy, differential scanning calorimetry, fluorescence, x-ray crystallography, and site-directed mutagenesis. Our on-going NIH-funded work is aimed at understanding the energetic and structural basis for the conformational plasticity of apolipoproteins. These are protein constituents of lipoproteins that mediate lipid transport and metabolism and are central in the pathogenesis of atherosclerosis, stroke, and certain forms of amyloidosis. Apolipoproteins are distinct in their structural adaptability to various lipoprotein particles and to plasma. We try to understand in molecular detail the energetic and structural basis for this adaptability. A major focus of our research is on the molecular mechanisms of lipoprotein stabilization and fusion. In 2002 we revealed that lipoprotein stability is determined by kinetic barriers. Similar barriers may modulate in-vivo lipoprotein transformations. Our goal is to obtain key molecular determinants for these energy barriers.
Self-Described Keywords protein structure-function
Self-Described Keywords protein spectroscopy
Self-Described Keywords protein stability
Self-Described Keywords Protein-lipid interactions
Self-Described Keywords Protein misfolding and amyloid diseases
Self-Described Keywords structural biology and spectroscopy

One or more keywords matched the following items that are connected to Gursky, Olga

Item TypeName
Concept Serum Amyloid A Protein
Concept Protein Binding
Concept Protein Conformation
Concept Protein Denaturation
Concept Protein Processing, Post-Translational
Concept Proteins
Concept Recombinant Fusion Proteins
Concept Recombinant Proteins
Concept Structure-Activity Relationship
Concept Molecular Structure
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Protein Folding
Concept Protein Isoforms
Concept Protein Renaturation
Concept Protein Structure, Quaternary
Concept Mutant Proteins
Concept Cholesterol Ester Transfer Proteins
Concept Protein Interaction Domains and Motifs
Concept Protein Multimerization
Concept Protein Stability
Concept Amyloidogenic Proteins
Concept Protein Unfolding
Concept Protein Interaction Maps
Concept Protein Aggregation, Pathological
Academic Article Thermal unfolding of human high-density apolipoprotein A-1: implications for a lipid-free molten globular state.
Academic Article High- and low-temperature unfolding of human high-density apolipoprotein A-2.
Academic Article Thermodynamic analysis of human plasma apolipoprotein C-1: high-temperature unfolding and low-temperature oligomer dissociation.
Academic Article Probing the conformation of a human apolipoprotein C-1 by amino acid substitutions and trimethylamine-N-oxide.
Academic Article Temperature-dependent beta-sheet formation in beta-amyloid Abeta(1-40) peptide in water: uncoupling beta-structure folding from aggregation.
Academic Article Probing the lipid-free structure and stability of apolipoprotein A-I by mutation.
Academic Article Complex of human apolipoprotein C-1 with phospholipid: thermodynamic or kinetic stability?
Academic Article Conformational changes in cubic insulin crystals in the pH range 7-11.
Academic Article Human plasma high-density lipoproteins are stabilized by kinetic factors.
Academic Article Effects of mutations in apolipoprotein C-1 on the reconstitution and kinetic stability of discoidal lipoproteins.
Academic Article Monovalent cation binding to cubic insulin crystals.
Academic Article Structural studies of N- and C-terminally truncated human apolipoprotein A-I.
Academic Article Lipid-binding studies of human apolipoprotein A-I and its terminally truncated mutants.
Academic Article Poly(ethylene glycol)-induced fusion and destabilization of human plasma high-density lipoproteins.
Academic Article Structural basis for thermal stability of human low-density lipoprotein.
Academic Article Kinetic stabilization and fusion of apolipoprotein A-2:DMPC disks: comparison with apoA-1 and apoC-1.
Academic Article Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma.
Academic Article Apolipoprotein structure and dynamics.
Academic Article Monitoring protein aggregation during thermal unfolding in circular dichroism experiments.
Academic Article Effects of salt on the thermal stability of human plasma high-density lipoprotein.
Academic Article Does alpha-helix folding necessarily provide an energy source for the protein-lipid binding?
Academic Article Role of secondary structure in protein-phospholipid surface interactions: reconstitution and denaturation of apolipoprotein C-I:DMPC complexes.
Academic Article Effects of oxidation on the structure and stability of human low-density lipoprotein.
Academic Article Mild oxidation promotes and advanced oxidation impairs remodeling of human high-density lipoprotein in vitro.
Academic Article Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins.
Academic Article Thermal transitions in human very-low-density lipoprotein: fusion, rupture, and dissociation of HDL-like particles.
Academic Article Effects of acyl chain length, unsaturation, and pH on thermal stability of model discoidal HDLs.
Academic Article Differential stability of high-density lipoprotein subclasses: effects of particle size and protein composition.
Academic Article Correlation of structural stability with functional remodeling of high-density lipoproteins: the importance of being disordered.
Academic Article Effects of cholesterol on thermal stability of discoidal high density lipoproteins.
Academic Article Pressure perturbation calorimetry of apolipoproteins in solution and in model lipoproteins.
Academic Article Effects of oxidation on structural stability and remodeling of human very low density lipoprotein.
Academic Article The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain.
Academic Article Effects of phospholipase A(2) and its products on structural stability of human LDL: relevance to formation of LDL-derived lipid droplets.
Academic Article Pressure perturbation calorimetry of lipoproteins reveals an endothermic transition without detectable volume changes. Implications for adsorption of apolipoprotein to a phospholipid surface.
Academic Article Folded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis.
Academic Article The crystal structure of the C-terminal truncated apolipoprotein A-I sheds new light on amyloid formation by the N-terminal fragment.
Academic Article Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis.
Academic Article Role of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): protein conformational ensemble on HDL.
Academic Article Crystal structure of ?(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoil.
Academic Article Changes in helical content or net charge of apolipoprotein C-I alter its affinity for lipid/water interfaces.
Academic Article Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I.
Academic Article Stereospecific dihaloalkane binding in a pH-sensitive cavity in cubic insulin crystals.
Academic Article Structure and selectivity of a monovalent cation binding site in cubic insulin crystals.
Academic Article Hot spots in apolipoprotein A-II misfolding and amyloidosis in mice and men.
Academic Article Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights.
Academic Article Preface. Role of lipids in protein misfolding.
Academic Article Structural stability and functional remodeling of high-density lipoproteins.
Academic Article Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis.
Academic Article Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL.
Academic Article Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic?
Academic Article Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA.
Academic Article Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases.
Academic Article Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks.
Academic Article Thermal stability of human plasma electronegative low-density lipoprotein: A paradoxical behavior of low-density lipoprotein aggregation.
Academic Article Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?
Academic Article Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks.
Grant Structural Thermodynamics of Human Apolipoprotein C-1
Grant Structural Thermodynamics of Human Apolipoprotein C-1
Academic Article Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a "molecular mop" in immune response.
Academic Article In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis.
Academic Article Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis.
Academic Article Structural and Immunological Characterization of Novel Recombinant MOMP-Based Chlamydial Antigens.
Academic Article Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner.
Academic Article Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease.
Academic Article Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins.
Academic Article Molecular Insights into Human Hereditary Apolipoprotein A-I Amyloidosis Caused by the Glu34Lys Mutation.
Academic Article Effects of triacylglycerol on the structural remodeling of human plasma very low- and low-density lipoproteins.
Academic Article Synergy between serum amyloid A and secretory phospholipase A2.
Academic Article Structure of Langmuir-Blodgett superlattices with alternative bilayers of barium behenate, phtalocyanine, and octadecyl ethylene phenol
Academic Article Circular Dichroism: Theory and Spectroscopy, D.S. Rogers, Edt. Nova Publishers pp. 175-215
Academic Article Energetic-structure-function of lipoproteins and their protein components. In: Recent research developments in proteins, S.G. Pandalai, edt., Transworld Res. Network, Vol. 1, pp. 97-121
Academic Article Advances in Experimental Medicine and Biology, 855
Academic Article Structural Basis for Lipid Binding and Function by an Evolutionarily Conserved Protein, Serum Amyloid A.
Academic Article Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia.
Academic Article Novel clinical manifestations and treatment of hereditary apoA-I amyloidosis: when a good protein turns bad.
Academic Article Structural Basis for Vital Function and Malfunction of Serum Amyloid A: an Acute-Phase Protein that Wears Hydrophobicity on Its Sleeve.
Grant Structural Stability and Functional Remodeling of High-density Lipoproteins
Grant Structure and Function of Serum Amyloid A in Health and Disease
Grant Structural Stability and Functional Remodeling of High-density Lipoproteins

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