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Search Results to Olga Gursky, PhD

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Research Expertise & Professional Interests Our research focus is on protein folding, structure and stability. It includes the analysis of the energetic-structure-function relationship and folding pathways in proteins and peptides by circular dichroism spectroscopy, differential scanning calorimetry, fluorescence, x-ray crystallography, and site-directed mutagenesis. Our on-going NIH-funded work is aimed at understanding the energetic and structural basis for the conformational plasticity of apolipoproteins. These are protein constituents of lipoproteins that mediate lipid transport and metabolism and are central in the pathogenesis of atherosclerosis, stroke, and certain forms of amyloidosis. Apolipoproteins are distinct in their structural adaptability to various lipoprotein particles and to plasma. We try to understand in molecular detail the energetic and structural basis for this adaptability. A major focus of our research is on the molecular mechanisms of lipoprotein stabilization and fusion. In 2002 we revealed that lipoprotein stability is determined by kinetic barriers. Similar barriers may modulate in-vivo lipoprotein transformations. Our goal is to obtain key molecular determinants for these energy barriers.
Self-Described Keywords lipoproteins

One or more keywords matched the following items that are connected to Gursky, Olga

Item TypeName
Concept Lipoprotein Lipase
Concept Lipoproteins
Concept Lipoproteins, HDL
Concept Lipoproteins, LDL
Concept Lipoproteins, VLDL
Academic Article Human plasma high-density lipoproteins are stabilized by kinetic factors.
Academic Article Effects of mutations in apolipoprotein C-1 on the reconstitution and kinetic stability of discoidal lipoproteins.
Academic Article Poly(ethylene glycol)-induced fusion and destabilization of human plasma high-density lipoproteins.
Academic Article Structural basis for thermal stability of human low-density lipoprotein.
Academic Article Electrostatic effects on the stability of discoidal high-density lipoproteins.
Academic Article Monitoring protein aggregation during thermal unfolding in circular dichroism experiments.
Academic Article Effects of salt on the thermal stability of human plasma high-density lipoprotein.
Academic Article Effects of oxidation on the structure and stability of human low-density lipoprotein.
Academic Article Mild oxidation promotes and advanced oxidation impairs remodeling of human high-density lipoprotein in vitro.
Academic Article Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins.
Academic Article Thermal transitions in human very-low-density lipoprotein: fusion, rupture, and dissociation of HDL-like particles.
Academic Article Effects of acyl chain length, unsaturation, and pH on thermal stability of model discoidal HDLs.
Academic Article Differential stability of high-density lipoprotein subclasses: effects of particle size and protein composition.
Academic Article Correlation of structural stability with functional remodeling of high-density lipoproteins: the importance of being disordered.
Academic Article Effects of cholesterol on thermal stability of discoidal high density lipoproteins.
Academic Article Pressure perturbation calorimetry of apolipoproteins in solution and in model lipoproteins.
Academic Article Effects of oxidation on structural stability and remodeling of human very low density lipoprotein.
Academic Article Effects of phospholipase A(2) and its products on structural stability of human LDL: relevance to formation of LDL-derived lipid droplets.
Academic Article Pressure perturbation calorimetry of lipoproteins reveals an endothermic transition without detectable volume changes. Implications for adsorption of apolipoprotein to a phospholipid surface.
Academic Article Human Plasma Very Low-Density Lipoproteins Are Stabilized by Electrostatic Interactions and Destabilized by Acidic pH.
Academic Article Folded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis.
Academic Article Kinetic analysis of thermal stability of human low density lipoproteins: a model for LDL fusion in atherogenesis.
Academic Article Role of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): protein conformational ensemble on HDL.
Academic Article Crystal structure of ?(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoil.
Academic Article Hot spots in apolipoprotein A-II misfolding and amyloidosis in mice and men.
Academic Article Aggregation and fusion of low-density lipoproteins in vivo and in vitro.
Academic Article Structural stability and functional remodeling of high-density lipoproteins.
Academic Article Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL.
Academic Article Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA.
Academic Article Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases.
Academic Article Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks.
Academic Article Thermal stability of human plasma electronegative low-density lipoprotein: A paradoxical behavior of low-density lipoprotein aggregation.
Academic Article Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks.
Academic Article Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a "molecular mop" in immune response.
Academic Article Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins.
Academic Article Effects of triacylglycerol on the structural remodeling of human plasma very low- and low-density lipoproteins.
Academic Article Synergy between serum amyloid A and secretory phospholipase A2.
Academic Article Circular Dichroism: Theory and Spectroscopy, D.S. Rogers, Edt. Nova Publishers pp. 175-215
Academic Article Energetic-structure-function of lipoproteins and their protein components. In: Recent research developments in proteins, S.G. Pandalai, edt., Transworld Res. Network, Vol. 1, pp. 97-121
Academic Article Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia.
Grant Structural Stability and Functional Remodeling of High-density Lipoproteins
Grant Structural Stability and Functional Remodeling of High-density Lipoproteins

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