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Search Results to George T. O'Connor, MD

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Research Expertise & Professional Interests My research focuses on epidemiology, including genetic epidemiology, and clinical investigations of asthma, allergy, chronic obstructive pulmonary disease, and sleep apnea. I have been the Boston University / Boston Medical Center principal investigator of multiple NIH-funded multi-center investigations, currently including the Inner-City Asthma Consortium (ICAC), the Vitamin D Antenatal Asthma Reduction Trial (VDAART), and the All of Us Research Program. Our ICAC studies include clinical trials in children and adolescents with asthma and a birth-cohort study examining the risk factors for asthma and allergy in the inner city. I also conduct epidemiologic and genetic epidemiologic research at the Framingham Heart Study, including genome-wide association studies seeking novel genetic determinants of lung function impairment, interstitial lung abnormalities, and atopy. I have collaborated with the Division of Computational Biomedicine's studies of alterations in gene expression related to tobacco smoking and COPD. My research spans disciplines including adult medicine, pediatrics, obstetrics, epidemiology, genetics and genomics, immunology, and environmental science. At Boston Medical Center, my outpatient practice focuses on adults with asthma, COPD, and bronchiectasis. I am an Associate Editor of JAMA.
Self-Described Keywords Asthma

One or more keywords matched the following items that are connected to O'Connor, George

Item TypeName
Concept Biomarkers
Academic Article Poverty, race, and medication use are correlates of asthma hospitalization rates. A small area analysis in Boston.
Academic Article Clinical and symptom measures.
Academic Article Predictors of longitudinal change in methacholine airway responsiveness among middle-aged and older men: the Normative Aging Study.
Academic Article The interrelationship among allergy, airways responsiveness, and asthma.
Academic Article Predictors of the new onset of wheezing among middle-aged and older men. The Normative Aging Study.
Academic Article Environmental tobacco smoke, wheezing, and asthma in children in 24 communities.
Academic Article Sensitization to cat allergen is associated with asthma in older men and predicts new-onset airway hyperresponsiveness. The Normative Aging Study.
Academic Article Cockroach allergy and asthma in a 30-year-old man.
Academic Article Indoor allergens and longitudinal FEV1 decline in older adults: the Normative Aging Study.
Academic Article Maximal and partial expiratory flow rates in a population sample of 10- to 11-yr-old schoolchildren. Effect of volume history and relation to asthma and maternal smoking.
Academic Article Socioeconomic predictors of high allergen levels in homes in the greater Boston area.
Academic Article Development and implementation of the home asthma telemonitoring (HAT) system to facilitate asthma self-care.
Academic Article Home and allergic characteristics of children with asthma in seven U.S. urban communities and design of an environmental intervention: the Inner-City Asthma Study.
Academic Article Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study.
Academic Article Asthma prevention. Task Force on Research and Education for the Prevention and Control of Respiratory Diseases.
Academic Article Particle concentrations in inner-city homes of children with asthma: the effect of smoking, cooking, and outdoor pollution.
Academic Article Results of a home-based environmental intervention among urban children with asthma.
Academic Article Airborne fungi in the homes of children with asthma in low-income urban communities: The Inner-City Asthma Study.
Academic Article Allergen avoidance in asthma: what do we do now?
Academic Article Cost-effectiveness of a home-based environmental intervention for inner-city children with asthma.
Academic Article Asthma, hay fever, and phlegm production associated with distinct patterns of allergy skin test reactivity, eosinophilia, and serum IgE levels. The Normative Aging Study.
Academic Article Association of asthma with a functional promoter polymorphism in the IL16 gene.
Academic Article Safety of long-acting beta-agonists.
Academic Article A randomized clinical trial of clinician feedback to improve quality of care for inner-city children with asthma.
Academic Article Clinical Decisions. Treatment of mild persistent asthma.
Academic Article Systemic inflammation and COPD: the Framingham Heart Study.
Academic Article Acute respiratory health effects of air pollution on children with asthma in US inner cities.
Academic Article Body mass index and asthma incidence in the Black Women's Health Study.
Academic Article Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial.
Academic Article The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population.
Academic Article Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
Academic Article Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children.
Academic Article Eosinophil and T cell markers predict functional decline in COPD patients.
Academic Article PDE11A associations with asthma: results of a genome-wide association scan.
Academic Article TSLP polymorphisms are associated with asthma in a sex-specific fashion.
Academic Article Asthma-susceptibility variants identified using probands in case-control and family-based analyses.
Academic Article Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma.
Academic Article Umbilical cord plasma 25-hydroxyvitamin D concentration and immune function at birth: the Urban Environment and Childhood Asthma study.
Academic Article Airway resistance at maximum inhalation as a marker of asthma and airway hyperresponsiveness.
Academic Article Genome-wide association study of lung function decline in adults with and without asthma.
Academic Article Inhaled corticosteroid dose adjustment in mild persistent asthma.
Academic Article Asthma outcomes: pulmonary physiology.
Academic Article Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
Academic Article Distribution and clinical correlates of the interleukin receptor family member soluble ST2 in the Framingham Heart Study.
Academic Article Abuse during childhood and adolescence and risk of adult-onset asthma in African American women.
Academic Article Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts.
Academic Article Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents.
Academic Article Vascular inflammation and sleep disordered breathing in a community-based cohort.
Academic Article Replication and fine mapping of asthma-associated loci in individuals of African ancestry.
Academic Article Analysis of dose-response curves to methacholine. An approach suitable for population studies.
Academic Article The effect of passive smoking on pulmonary function and nonspecific bronchial responsiveness in a population-based sample of children and young adults.
Academic Article Elastin and collagen degradation products in urine of smokers with and without chronic obstructive pulmonary disease.
Academic Article Normal range of methacholine responsiveness in relation to prechallenge pulmonary function. The Normative Aging Study.
Academic Article The Vitamin D Antenatal Asthma Reduction Trial (VDAART): rationale, design, and methods of a randomized, controlled trial of vitamin D supplementation in pregnancy for the primary prevention of asthma and allergies in children.
Academic Article Cord blood vitamin D concentrations are unrelated to atopy and wheeze in 2 diverse birth cohort studies.
Academic Article Experiences of racism and the incidence of adult-onset asthma in the Black Women''s Health Study.
Academic Article Development of cockroach immunotherapy by the Inner-City Asthma Consortium.
Academic Article Reassessment of omalizumab-dosing strategies and pharmacodynamics in inner-city children and adolescents.
Academic Article Association of exhaled carbon monoxide with subclinical cardiovascular disease and their conjoint impact on the incidence of cardiovascular outcomes.
Academic Article Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children.
Academic Article Depressive symptoms and the incidence of adult-onset asthma in African American women.
Academic Article Seasonal risk factors for asthma exacerbations among inner-city children.
Academic Article DNA methylation and childhood asthma in the inner city.
Academic Article Active and passive smoking and the incidence of asthma in the Black Women''s Health Study.
Academic Article DNA Methylation Changes in Nasal Epithelia Are Associated with Allergic Asthma in the Inner City.
Academic Article The influence of atopy and asthma on immune responses in inner-city adults.
Academic Article The nasal methylome and childhood atopic asthma.
Academic Article Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART).
Academic Article Asthma phenotypes in inner-city children.
Academic Article Pathways through which asthma risk factors contribute to asthma severity in inner-city children.
Academic Article Neighborhood and Individual Socioeconomic Status and Asthma Incidence in African American Women.
Academic Article Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial.
Academic Article Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial.
Academic Article Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
Academic Article Asthma-Here Today, Gone Tomorrow?
Academic Article NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.
Grant Epidemiology of IL-16 Polymorphism and Asthma Severity
Grant Evaluation of Home Asthma Telemonitoring (HAT) in Adults
Grant Asthma Control Evaluation (ACE): A Biomarker-Based Approach to Improving Asthma Control
Grant Trial of Interventions to Reduce Asthma Morbidity
Academic Article Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial.
Academic Article Asthma control status in pregnancy, body mass index, and maternal vitamin D levels.
Academic Article Screen Time Engagement Is Increased in Urban Children With Asthma.
Academic Article The Association of Maternal Asthma and Early Pregnancy Vitamin D with Risk of Preeclampsia: An Observation From Vitamin D Antenatal Asthma Reduction Trial (VDAART).
Academic Article Early-life home environment and risk of asthma among inner-city children.
Academic Article MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage.
Academic Article Obstruction phenotype as a predictor of asthma severity and instability in children.
Academic Article Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Academic Article Correction: Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA.
Academic Article Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment.
Academic Article Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy.
Academic Article Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma.
Academic Article Serum a1-Antitrypsin Concentration in the Diagnosis of a1-Antitrypsin Deficiency.
Academic Article Longitudinal Phenotypes of Respiratory Health in a High-Risk Urban Birth Cohort.
Academic Article Dietary and Plasma Polyunsaturated Fatty Acids Are Inversely Associated with Asthma and Atopy in Early Childhood.
Academic Article Impact of Preeclampsia on the Relationship between Maternal Asthma and Offspring Asthma. An Observation from the VDAART Clinical Trial.
Academic Article Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.
Academic Article Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children.
Academic Article A computerized decision support tool to implement asthma guidelines for children and adolescents.
Academic Article Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
Academic Article Integrative analysis of the intestinal metabolome of childhood asthma.
Academic Article Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.
Academic Article The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age.
Academic Article Maternal Asthma, Preeclampsia, and Risk for Childhood Asthma at Age Six.
Academic Article The Children''s Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population.
Academic Article Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort.
Academic Article Fecal short-chain fatty acids in pregnancy and offspring asthma and allergic outcomes.
Academic Article Serum IL-6: A biomarker in childhood asthma?
Academic Article Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction.
Academic Article New Therapeutic Strategies for Asthma.
Academic Article Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2.
Academic Article Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Academic Article Effect of early and late prenatal vitamin D and maternal asthma status on offspring asthma or recurrent wheeze.
Academic Article The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality.
Grant Inner City Asthma Consortium 3 (ICAC3)
Grant Vitamin D Antenatally for Asthma Reduction Trial (VDAART)
Grant Inner City Asthma Consortium 3 (ICAC3)
Grant Inner-City Asthma Consortium(ICAC)-Immunologic Approaches to Reduce Asthma CORE
Grant Multi-Omic Approaches To Mechanisms Of Vitamin D, Environmental Influences, And The Microbiome On Asthma
Grant Multi-Omic Approaches To Mechanisms Of Vitamin D, Environmental Influences, And The Microbiome On Asthma

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  • Biomarkers
  • Asthma