Search Results to Michael J Pencina, PhD

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Research Expertise & Professional Interests Dr. Michael Pencina is the Duke Clinical Research Institute Director of Biostatistics. He is Professor of Biostatistics & Bioinformatics at Duke and Adjunct Professor in the Department of Biostatistics at Boston University. As the DCRI Director of Biostatistics, Dr. Pencina serves as a key institutional leader overseeing the strategic and operational direction of our biostatistics talent and resources at the DCRI. In this role, Dr. Pencina guides a strategic vision to meet the needs of DCRI investigators by developing necessary infrastructure while also partnering with the Biostatistics & Bioinformatics Department to assure that the DCRI’s objectives and services are well understood and supported. Prior to joining the DCRI in 2013, Dr. Pencina served as an associate professor in the Department of Biostatistics at Boston University and as Director of Statistical Consulting at the Harvard Clinical Research Institute. He brings a wealth of experience in both clinical trials and observational analyses. He has worked on a number of large clinical trials as well as Framingham Heart Study projects. Dr. Pencina is an expert in cardiovascular disease risk prediction model development and assessment of performance. The novel metrics (net reclassification improvement and integrated discrimination improvement) for the assessment of usefulness of new biomarkers and genetic factors in risk prediction proposed by Dr. Pencina have been incorporated into the reporting guidelines. For the past year, Dr. Pencina has also served as the Associate Editor for Statistics in Medicine. He has authored more than 150 manuscripts that have been published in peer-reviewed journals. Dr. Pencina earned his PhD in Mathematics and Statistics at Boston University.

One or more keywords matched the following items that are connected to Pencina, Michael

Item TypeName
Concept Asthma
Concept Biomarkers, Tumor
Concept Biomarkers
Academic Article C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study.
Academic Article Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study.
Academic Article The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases.
Academic Article Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study.
Academic Article Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring.
Academic Article Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community.
Academic Article Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community.
Academic Article Novel and conventional biomarkers for prediction of incident cardiovascular events in the community.
Academic Article Arterial stiffness and cardiovascular events: the Framingham Heart Study.
Academic Article Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD.
Academic Article Prognostic impact of periprocedural bleeding and myocardial infarction after percutaneous coronary intervention in unselected patients: results from the EVENT (evaluation of drug-eluting stents and ischemic events) registry.
Academic Article Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community.
Academic Article Improvement of cardiovascular risk prediction: time to review current knowledge, debates, and fundamentals on how to assess test characteristics.
Academic Article Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms.
Academic Article C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study.
Academic Article Relations of biomarkers of distinct pathophysiological pathways and atrial fibrillation incidence in the community.
Academic Article Cross-sectional relations of lipid concentrations to left ventricular structural attributes.
Academic Article Statistical methods for assessment of added usefulness of new biomarkers.
Academic Article Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers.
Academic Article Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study.
Academic Article Performance of current guidelines for coronary heart disease prevention: optimal use of the Framingham-based risk assessment.
Academic Article Prevalence of low ankle-brachial index, elevated plasma fibrinogen and CRP across Framingham risk categories: data from the National Health and Nutrition Examination Survey (NHANES) 1999-2004.
Academic Article Higher aldosterone and lower N-terminal proatrial natriuretic peptide as biomarkers of salt sensitivity in the community.
Academic Article Assessing the incremental value of diagnostic and prognostic markers: a review and illustration.
Academic Article [Performance measures for prediction models and markers: evaluation of predictions and classifications].
Academic Article Adjustment of the GRACE score by growth differentiation factor 15 enables a more accurate appreciation of risk in non-ST-elevation acute coronary syndrome.
Academic Article Comparative value of coronary artery calcium and multiple blood biomarkers for prognostication of cardiovascular events.
Academic Article Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the community.
Academic Article Caution is needed in the interpretation of added value of biomarkers analyzed in matched case control studies.
Academic Article Red cell distribution width is a predictor of mortality in patients undergoing percutaneous coronary intervention.
Academic Article Interpreting incremental value of markers added to risk prediction models.
Academic Article Pencina et al. respond to "The incremental value of new markers" and "Clinically relevant measures? A note of caution".
Academic Article [Discriminative ability, reclassification and net benefit: the predictive value of biomarkers].
Academic Article Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.
Academic Article Relation of circulating liver transaminase concentrations to risk of new-onset atrial fibrillation.
Academic Article Evaluation of markers and risk prediction models: overview of relationships between NRI and decision-analytic measures.
Academic Article Validation of a breast cancer risk prediction model developed for Black women.
Academic Article Sex-specific differences in the predictive value of cholesterol homeostasis markers and 10-year cardiovascular disease event rate in Framingham Offspring Study participants.
Academic Article General medical burden in bipolar disorder: findings from the LiTMUS comparative effectiveness trial.
Academic Article Charting a roadmap for heart failure biomarker studies.
Academic Article Biomarkers of myocardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure.
Academic Article Serial measurements of N-terminal pro-brain natriuretic peptide in patients with coronary heart disease.
Academic Article Apolipoprotein B improves risk assessment of future coronary heart disease in the Framingham Heart Study beyond LDL-C and non-HDL-C.
Academic Article Incremental prognostic value of biomarkers beyond the GRACE (Global Registry of Acute Coronary Events) score and high-sensitivity cardiac troponin T in non-ST-elevation acute coronary syndrome.
Academic Article What to expect from net reclassification improvement with three categories.
Academic Article Clinical implications of chronic heart failure phenotypes defined by cluster analysis.
Academic Article On the quantitative assessment of predictive biomarkers.
Academic Article Impact of correlation on predictive ability of biomarkers.
Academic Article Sensitivity and specificity can change in opposite directions when new predictive markers are added to risk models.
Academic Article Assessing the incremental predictive performance of novel biomarkers over standard predictors.
Academic Article Graphical assessment of incremental value of novel markers in prediction models: From statistical to decision analytical perspectives.
Academic Article RE: net risk reclassification P Values: valid or misleading?
Academic Article B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk: the CHARGE-AF Consortium of community-based cohort studies.
Academic Article Inference for reclassification statistics under nested and non-nested models for biomarker evaluation.
Academic Article Association of obesity and inflammatory marker levels on treatment outcome: results from a double-blind, randomized study of adjunctive L-methylfolate calcium in patients with MDD who are inadequate responders to SSRIs.
Academic Article A comparison of time dependent Cox regression, pooled logistic regression and cross sectional pooling with simulations and an application to the Framingham Heart Study.
Academic Article Anticholinergic vs Long-Acting ß-Agonist in Combination With Inhaled Corticosteroids in Black Adults With Asthma: The BELT Randomized Clinical Trial.
Academic Article Risk scores and biomarkers for the prediction of 1-year outcome after transcatheter aortic valve replacement.
Academic Article Low-density lipoprotein cholesterol and survival in pulmonary arterial hypertension.
Academic Article Nonparametric estimation and inference for polytomous discrimination index.
Academic Article Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk.
Academic Article High-sensitivity C-reactive protein elevation in patients with prior myocardial infarction in the United States.
Academic Article Microsimulation model to predict incremental value of biomarkers added to prognostic models.
Academic Article Statistical methods for building better biomarkers of chronic kidney disease.
Academic Article ApoB.
Academic Article Single Measurements of Carboxy-Terminal Fibroblast Growth Factor 23 and Clinical Risk Prediction of Adverse Outcomes in CKD.
Academic Article Cost-effectiveness of Low-density Lipoprotein Cholesterol Level-Guided Statin Treatment in Patients With Borderline Cardiovascular Risk.
Academic Article Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review.
Academic Article Adherence to adding inhaled corticosteroids to rescue therapy in a pragmatic trial with adults with asthma: A pilot study.

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  • Biomarkers
  • Asthma