Search Results to Ann C. McKee, MD

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Research Expertise & Professional Interests Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank. Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy. Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).
Self-Described Keywords tau protein

One or more keywords matched the following items that are connected to McKee, Ann

Item TypeName
Concept tau Proteins
Academic Article Morphometric image analysis of neuropil threads in Alzheimer's disease.
Academic Article Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients.
Academic Article Neuritic pathology and dementia in Alzheimer's disease.
Academic Article Visual association pathology in preclinical Alzheimer disease.
Academic Article Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase.
Academic Article Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.
Academic Article Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease.
Academic Article Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.
Academic Article The spectrum of disease in chronic traumatic encephalopathy.
Academic Article The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.
Academic Article Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy.
Academic Article Beta-amyloid deposition in chronic traumatic encephalopathy.
Academic Article R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer''s disease.
Academic Article The neuropathology of chronic traumatic encephalopathy.
Academic Article Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy.
Academic Article Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer''s disease.
Academic Article Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.
Academic Article A quantitative study of tau pathology in 11 cases of chronic traumatic encephalopathy.
Academic Article Pathology of the Superior Colliculus in Chronic Traumatic Encephalopathy.
Academic Article Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy.
Academic Article Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study.
Academic Article Clustering of tau-immunoreactive pathology in chronic traumatic encephalopathy.
Academic Article Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank.
Academic Article Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation?
Academic Article Tau prions from Alzheimer''s disease and chronic traumatic encephalopathy patients propagate in cultured cells.
Academic Article Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy.
Academic Article Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football.
Academic Article Psychiatric phenotypes in chronic traumatic encephalopathy.
Academic Article Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.
Academic Article Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies.
Academic Article Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS.
Academic Article Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study.
Academic Article Age of first exposure to tackle football and chronic traumatic encephalopathy.
Academic Article Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports.
Academic Article Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.
Academic Article Astrocytic degeneration in chronic traumatic encephalopathy.
Academic Article Variation in TMEM106B in chronic traumatic encephalopathy.
Academic Article Positron emission tomography of tau in Iraq and Afghanistan Veterans with blast neurotrauma.
Academic Article Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article [18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series.

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