Search Results to Ann C. McKee, MD

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Research Expertise & Professional Interests Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank. Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy. Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).
Self-Described Keywords neuropathological alterations of neurodegenerative diseases
Self-Described Keywords pathological disease

One or more keywords matched the following items that are connected to McKee, Ann

Item TypeName
Concept Alzheimer Disease
Concept Brain Diseases
Concept Carotid Artery Diseases
Concept Chronic Disease
Concept Disease Models, Animal
Concept Huntington Disease
Concept Parkinson Disease
Concept Parkinson Disease, Secondary
Concept Vascular Diseases
Concept Motor Neuron Disease
Concept Disease Progression
Concept Neurodegenerative Diseases
Concept Genetic Predisposition to Disease
Concept Pick Disease of the Brain
Concept Lewy Body Disease
Academic Article Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease.
Academic Article Morphometric image analysis of neuropil threads in Alzheimer's disease.
Academic Article The histopathology of neuronal degeneration and plasticity in Alzheimer disease.
Academic Article Neuritic pathology and dementia in Alzheimer's disease.
Academic Article Brain banking: basic science methods.
Academic Article Near-infrared fluorescence spectroscopy detects Alzheimer's disease in vitro.
Academic Article Enhanced inhibition of free radical-induced deoxyribose breakdown by Alzheimer brain homogenates.
Academic Article The neurotoxicity of amyloid beta protein in aged primates.
Academic Article MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.
Academic Article Serum amyloid A in Alzheimer's disease brain is predominantly localized to myelin sheaths and axonal membrane.
Academic Article Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration.
Academic Article Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease.
Academic Article Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology.
Academic Article Disturbance of endogenous circadian rhythm in aging and Alzheimer disease.
Academic Article APOE, vascular pathology, and the AD brain.
Academic Article Re-assessing the relationship between cholesterol, statins and Alzheimer's disease.
Academic Article Visual association pathology in preclinical Alzheimer disease.
Academic Article Sepiapterin reductase expression is increased in Parkinson's disease brain tissue.
Academic Article Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase.
Academic Article Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia.
Academic Article Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.
Academic Article Scattering differentiates Alzheimer disease in vitro.
Academic Article Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease.
Academic Article Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein.
Academic Article Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
Academic Article Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
Academic Article TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
Academic Article Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma.
Academic Article Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue.
Academic Article Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice.
Academic Article Pyroglutamate-Aß 3 and 11 colocalize in amyloid plaques in Alzheimer's disease cerebral cortex with pyroglutamate-Aß 11 forming the central core.
Academic Article Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Academic Article Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions.
Academic Article Long-term consequences: effects on normal development profile after concussion.
Academic Article Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease.
Academic Article The Framingham Brain Donation Program: neuropathology along the cognitive continuum.
Academic Article Increased expression of TrkB and Capzb2 accompanies preserved cognitive status in early Alzheimer disease pathology.
Academic Article Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature.
Academic Article Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.
Academic Article Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
Academic Article Central pontine myelinolysis in severely burned patients: relationship to serum hyperosmolality.
Academic Article d-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.
Academic Article Clinical presentation of chronic traumatic encephalopathy.
Academic Article The spectrum of disease in chronic traumatic encephalopathy.
Academic Article Microtubular reorganization and dendritic growth response in Alzheimer's disease.
Academic Article Marked changes in mitochondrial DNA deletion levels in Alzheimer brains.
Academic Article Association between neuropathology and brain volume in the Framingham Heart Study.
Academic Article The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.
Academic Article Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy.
Academic Article A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI.
Academic Article Beta-amyloid deposition in chronic traumatic encephalopathy.
Academic Article R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer''s disease.
Academic Article Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Academic Article Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
Academic Article Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy.
Academic Article Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study.
Academic Article Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer''s disease.
Academic Article Post-traumatic neurodegeneration and chronic traumatic encephalopathy.
Academic Article At the interface of sensory and motor dysfunctions and Alzheimer''s disease.
Academic Article Chronic traumatic encephalopathy: a neurodegenerative consequence of repetitive traumatic brain injury.
Academic Article Concussion in Chronic Traumatic Encephalopathy.
Academic Article Interaction Between Midlife Blood Glucose and APOE Genotype Predicts Later Alzheimer''s Disease Pathology.
Academic Article Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study.
Academic Article Clustering of tau-immunoreactive pathology in chronic traumatic encephalopathy.
Academic Article Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank.
Academic Article Chronic Traumatic Encephalopathy: Is Latency in Symptom Onset Explained by Tau Propagation?
Academic Article Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player.
Academic Article Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition.
Academic Article Tau prions from Alzheimer''s disease and chronic traumatic encephalopathy patients propagate in cultured cells.
Academic Article Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer''s Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer''s Coordinating Center Data Set.
Academic Article Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer''s disease.
Academic Article CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer''s disease.
Academic Article SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer''s disease.
Academic Article Characterization of Detergent Insoluble Proteome in Chronic Traumatic Encephalopathy.
Academic Article Pathologic Thr175 tau phosphorylation in CTE and CTE with ALS.
Academic Article Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
Academic Article Age of first exposure to tackle football and chronic traumatic encephalopathy.
Academic Article A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer''s Disease Neuropathology.
Academic Article Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports.
Academic Article Astrocytic degeneration in chronic traumatic encephalopathy.
Academic Article Cortical degeneration in chronic traumatic encephalopathy and Alzheimer''s disease neuropathologic change.
Academic Article Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article Failure to detect an association between self-reported traumatic brain injury and Alzheimer''s disease neuropathology and dementia.
Academic Article Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer''s Coordinating Center Uniform Data Set.
Academic Article Author Correction: Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article Mid-life and late-life vascular risk factor burden and neuropathology in old age.
Grant Boston University Alzheimer's Disease Core Center
Academic Article Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer''s disease.
Academic Article A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer''s disease.
Grant Tau Pathology in CTE vs. Alzheimer's Disease: Microvasculopathy and Neuroinflammation
Grant The Contribution of Age-Related Tauopathies to Alzheimer's Disease
Grant Radiological Pathological Correlations in the Injured Human Brain

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