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Search Results to Ann C. McKee, MD

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Research Expertise & Professional Interests Dr. McKee completed her undergraduate studies at the University of Wisconsin and received her medical degree from the Case Western Reserve School of Medicine. She completed residency training in neurology at Cleveland Metropolitan General Hospital and fellowship training in neuropathology at Massachusetts General Hospital. She was Assistant Professor of Neuropathology at Harvard Medical School from 1991-94, when she became Associate Professor of Neurology and Pathology at Boston University School of Medicine. In 2011, she was promoted to Professor of Neurology and Pathology. Dr. McKee directs the Neuropathology Service for the New England Veterans Administration Medical Centers (VISN-1) and the Brain Banks for the Boston University Alzheimer’s Disease Center, Center for the Study of Traumatic Encephalopathy, Framingham Heart Study, and Centenarian Study, which are all based at the Bedford VAMC. Dr. McKee is also the Chief Neuropathologist for the National VA ALS Brain Bank. Dr. McKee’s research interests center on the neuropathological alterations of neurodegenerative diseases, with a primary focus on the role of tau protein, axonal injury, trauma, vascular injury, and neurodegeneration. Much of her current work centers on mild traumatic brain injury from contact sports and military service and its long-term consequences. As a board-certified neurologist and neuropathologist, she is particularly interested in the clinical, behavioral and psychological manifestations of pathological disease and the neuroanatomical localization of clinical symptoms. She has written widely on many neurodegenerative diseases including Alzheimer’s disease, Lewy Body disease, Parkinson’s Disease, Progressive Supranuclear Palsy, Multiple System Atrophy, Frontotemporal Degeneration, Corticobasal Degeneration and Chronic Traumatic Encephalopathy (CTE). She has been an invited participant in several NIH-sponsored workshops on Progressive Supranuclear Palsy, Vascular Dementia and Traumatic Brain Injury. Dr. McKee’s work has been essential in establishing the clinical and pathological spectrum of trauma induced neurodegenerative disease, including CTE and Chronic Traumatic Encephalomyelopathy. Recently, she has received widespread acclaim for her case series featured in the Journal of the American Medical Association (JAMA) that found nearly every former National Football League (NFL) player who played at least one regular season game and whose brain then was donated for research was diagnosed post-mortem with Chronic Traumatic Encephalopathy (CTE).
Self-Described Keywords axonal injury
Self-Described Keywords vascular injury

One or more keywords matched the following items that are connected to McKee, Ann

Item TypeName
Concept War-Related Injuries
Concept Athletic Injuries
Concept Blast Injuries
Concept Brain Injuries
Concept Head Injuries, Closed
Concept Brain Injury, Chronic
Concept Vascular System Injuries
Academic Article Serum amyloid A in Alzheimer's disease brain is predominantly localized to myelin sheaths and axonal membrane.
Academic Article Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
Academic Article Mild traumatic brain injury: a risk factor for neurodegeneration.
Academic Article TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
Academic Article The epidemiology of sport-related concussion.
Academic Article Helmets and mouth guards: the role of personal equipment in preventing sport-related concussions.
Academic Article Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma.
Academic Article Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy.
Academic Article Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions.
Academic Article Long-term consequences: effects on normal development profile after concussion.
Academic Article Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma.
Academic Article Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.
Academic Article Profile of self-reported problems with executive functioning in college and professional football players.
Academic Article Clinical presentation of chronic traumatic encephalopathy.
Academic Article The spectrum of disease in chronic traumatic encephalopathy.
Academic Article The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.
Academic Article Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy.
Academic Article Military-related traumatic brain injury and neurodegeneration.
Academic Article Beta-amyloid deposition in chronic traumatic encephalopathy.
Academic Article The neuropathology of chronic traumatic encephalopathy.
Academic Article Frequency of head-impact-related outcomes by position in NCAA division I collegiate football players.
Academic Article Ice Hockey Summit II: zero tolerance for head hits and fighting.
Academic Article Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy.
Academic Article Considerations for animal models of blast-related traumatic brain injury and chronic traumatic encephalopathy.
Academic Article Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study.
Academic Article The neuropathology of sport.
Academic Article Ice Hockey Summit II: zero tolerance for head hits and fighting.
Academic Article Post-traumatic neurodegeneration and chronic traumatic encephalopathy.
Academic Article Author''s reply: To PMID 19535999.
Academic Article The neuropathology of traumatic brain injury.
Academic Article Chronic traumatic encephalopathy: a neurodegenerative consequence of repetitive traumatic brain injury.
Academic Article Concussion in Chronic Traumatic Encephalopathy.
Academic Article Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy.
Academic Article Clustering of tau-immunoreactive pathology in chronic traumatic encephalopathy.
Academic Article Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank.
Academic Article Potential Long-Term Consequences of Concussive and Subconcussive Injury.
Academic Article Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination.
Academic Article Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player.
Academic Article Quantitative validation of a nonlinear histology-MRI coregistration method using generalized Q-sampling imaging in complex human cortical white matter.
Academic Article Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football.
Academic Article Shining (Laser) Light on Traumatic Brain Injury Blood Biomarkers.
Academic Article Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes.
Academic Article Brain Banks and Tissue Repositories for Blast-Related Chronic Traumatic Encephalopathy Research.
Academic Article Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies.
Academic Article Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
Academic Article Assessing Subconcussive Head Impacts in Athletes Playing Contact Sports-The Eyes Have It.
Academic Article Positron emission tomography of tau in Iraq and Afghanistan Veterans with blast neurotrauma.
Academic Article Failure to detect an association between self-reported traumatic brain injury and Alzheimer''s disease neuropathology and dementia.
Academic Article Embolism of cerebral tissue to lungs: report of two cases and review of the literature.
Academic Article Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy.
Academic Article Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy.
Academic Article Late contributions of repetitive head impacts and TBI to depression symptoms and cognition.
Grant Traumatic Brain Injury and Repetitive Head Impacts: Contributions to AD/ADRD and CTE Neuropathology and Resulting Clinical Syndromes

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  • axonal
  • injury