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Research Expertise & Professional Interests Dr. Neil W. Kowall was born in Calgary, Canada and graduated with his MD from the University of British Columbia. He moved to Boston for postgraduate training in Internal Medicine at the Beth Israel Deaconess Hospital followed by a Neurology residency at Massachusetts General Hospital. After finishing his clinical training, he completed a postdoctoral research fellowship and was appointed Assistant Professor of Neurology at Massachusetts General Hospital and Harvard Medical School. He moved to the VA and Boston University in 1992 where he is currently Professor of Neurology and Pathology, Chief of Neurology at VA Boston Healthcare System, Director of the VA New England Geriatric Research Education and Clinical Center and Director of the NIH-funded Boston University Alzheimer’s Disease Center. He has published over 199 original reports. His major research interests are human neuroanatomy and neuropathology and the use of animal models to test novel therapies for neurodegenerative diseases including Alzheimer’s disease. Dr. Kowall’s research interests include the following: human neuroanatomy, immunocytochemistry and enzyme histochemistry of the brain, neuropathological basis of neurological disorders, animal models of neurological diseases, geriatric neurology, and cognitive decline in the elderly.

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Concept Acquired Immunodeficiency Syndrome
Concept Alleles
Concept Alzheimer Disease
Concept Amino Acid Sequence
Concept Amyotrophic Lateral Sclerosis
Concept Fabry Disease
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Antigens, Surface
Concept Base Sequence
Concept Behavioral Symptoms
Concept Brain Diseases
Concept Brain Stem
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Concept Corpus Striatum
Concept Cross-Sectional Studies
Concept Cytochrome P-450 Enzyme System
Concept Disease Models, Animal
Concept Drug Administration Schedule
Concept Educational Status
Concept Electric Stimulation
Concept Follow-Up Studies
Concept Multigene Family
Concept Tourette Syndrome
Concept HIV Seropositivity
Concept Huntington Disease
Concept Lac Operon
Concept Limbic System
Concept Longitudinal Studies
Concept Mental Status Schedule
Concept Mice, Mutant Strains
Concept Molecular Sequence Data
Concept Motor Skills
Concept Multiple Sclerosis
Concept Nervous System Diseases
Concept Synaptic Transmission
Concept Magnetic Resonance Spectroscopy
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Concept Parkinson Disease
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Concept Peripheral Nervous System Diseases
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Concept Psychiatric Status Rating Scales
Concept Rats, Inbred Strains
Concept Receptors, Cell Surface
Concept Retrospective Studies
Concept Rubinstein-Taybi Syndrome
Concept Saccades
Concept Saccharomyces cerevisiae
Concept Scattering, Radiation
Concept Sensitivity and Specificity
Concept Septal Nuclei
Concept Serotonin
Concept Severity of Illness Index
Concept Sex Factors
Concept Sleep
Concept Somatostatin
Concept Spectrometry, Fluorescence
Concept Spectrophotometry, Infrared
Concept Spectrum Analysis, Raman
Concept Spermidine
Concept Spinal Cord
Concept Sports
Concept Staining and Labeling
Concept Status Epilepticus
Concept Steroid Hydroxylases
Concept Stress Disorders, Post-Traumatic
Concept Structure-Activity Relationship
Concept Subcellular Fractions
Concept Substance P
Concept Substantia Innominata
Concept Substantia Nigra
Concept Succinate Dehydrogenase
Concept Sulfoglycosphingolipids
Concept Sulfonamides
Concept Superoxide Dismutase
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Concept Tumor Suppressor Protein p53
Concept Free Radical Scavengers
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Concept Motor Neuron Disease
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Concept Spatial Memory
Academic Article Involvement of NPY-immunoreactive neurons in the cerebral cortex of amyotrophic lateral sclerosis patients.
Academic Article Allele epsilon 4 of apolipoprotein E shows a dose effect on age at onset of Pick disease.
Academic Article 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice.
Academic Article Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.
Academic Article Role of vasogenic edema and tissue cavitation in ischemic evolution on diffusion-weighted imaging: comparison with multiparameter MR and immunohistochemistry.
Academic Article Homocysteic acid lesions in rat striatum spare somatostatin-neuropeptide Y (NADPH-diaphorase) neurons.
Academic Article The role of ferritin and hemosiderin in the MR appearance of cerebral hemorrhage: a histopathologic biochemical study in rats.
Academic Article Elevated levels of the endosomal-lysosomal proteinase cathepsin D in cerebrospinal fluid in Alzheimer disease.
Academic Article Movement disorder following excitotoxin lesions in primates.
Academic Article 3-Acetylpyridine produces age-dependent excitotoxic lesions in rat striatum.
Academic Article Measurement of severity in advanced Alzheimer's disease.
Academic Article Malonate produces striatal lesions by indirect NMDA receptor activation.
Academic Article Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors.
Academic Article Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
Academic Article Substance P-like immunoreactive neurons are depleted in Alzheimer's disease cerebral cortex.
Academic Article An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.
Academic Article Neuropathologic asymmetries in the brain of a patient with a unilateral status epilepticus.
Academic Article Morphometric image analysis of neuropil threads in Alzheimer's disease.
Academic Article Immunohistochemical patterns of selective cellular vulnerability in human cerebral ischemia.
Academic Article Similarities between beta amyloid peptides 1-40 and 40-1: effects on aggregation, toxicity in vitro, and injection in young and aged rats.
Academic Article Patterns of neuronal degeneration in the motor cortex of amyotrophic lateral sclerosis patients.
Academic Article Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.
Academic Article The histopathology of neuronal degeneration and plasticity in Alzheimer disease.
Academic Article Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization.
Academic Article Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury.
Academic Article Increased expression of basic fibroblast growth factor (bFGF) following focal cerebral infarction in the rat.
Academic Article Intrathecal synthesis of anti-sulfatide IgG is associated with peripheral nerve disease in acquired immunodeficiency syndrome.
Academic Article Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum.
Academic Article Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra.
Academic Article Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo.
Academic Article Oxidative damage in Alzheimer's.
Academic Article Myocyte-specific enhancer binding factor 2C expression in gerbil brain following global cerebral ischemia.
Academic Article Neuritic pathology and dementia in Alzheimer's disease.
Academic Article Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation.
Academic Article Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis.
Academic Article Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis.
Academic Article Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine.
Academic Article Alzheimer disease 1999: a status report.
Academic Article Near-infrared fluorescence spectroscopy detects Alzheimer's disease in vitro.
Academic Article Enhanced inhibition of free radical-induced deoxyribose breakdown by Alzheimer brain homogenates.
Academic Article The neurotoxicity of amyloid beta protein in aged primates.
Academic Article Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy.
Academic Article Neurotoxicity and oxidative damage of beta amyloid 1-42 versus beta amyloid 1-40 in the mouse cerebral cortex.
Academic Article Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease.
Academic Article MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons.
Academic Article No difference in plasma or urinary F2-isoprostanes among patients with Huntington's disease or Alzheimer's disease and controls.
Academic Article Transgenic ALS mice show increased vulnerability to the mitochondrial toxins MPTP and 3-nitropropionic acid.
Academic Article Hippocampal injections of amyloid beta-peptide 1-40 impair subsequent one-trial/day reward learning.
Academic Article Thy-1 in hippocampus: normal anatomy and neuritic growth in Alzheimer's disease.
Academic Article Therapeutic effects of cystamine in a murine model of Huntington's disease.
Academic Article Fabry disease: immunocytochemical characterization of neuronal involvement.
Academic Article In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment.
Academic Article Cytochrome C and caspase-9 expression in Huntington's disease.
Academic Article Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus.
Academic Article Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile.
Academic Article Prenatal choline deficiency decreases the cross-sectional area of cholinergic neurons in the medial septal nucleus.
Academic Article Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice.
Academic Article Influence of executive function on locomotor function: divided attention increases gait variability in Alzheimer's disease.
Academic Article Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
Academic Article Glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillary tangles in Alzheimer's disease.
Academic Article Phosphorylated neurofilament epitopes in the achromasic neurons of corticonigral degeneration.
Academic Article Proliferative and degenerative changes in striatal spiny neurons in Huntington's disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry.
Academic Article Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis.
Academic Article Selective sparing of NADPH-diaphorase-somatostatin-neuropeptide Y neurons in ischemic gerbil striatum.
Academic Article Mice lacking alpha-synuclein are resistant to mitochondrial toxins.
Academic Article Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.
Academic Article The role of ferritin and hemosiderin in the MR appearance of cerebral hemorrhage: a histopathologic biochemical study in rats.
Academic Article Visual association pathology in preclinical Alzheimer disease.
Academic Article Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response.
Academic Article Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats.
Academic Article NADPH diaphorase histochemistry of the human hypothalamus.
Academic Article Response:Model of Huntington's disease.
Academic Article Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase.
Academic Article Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice.
Academic Article Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia.
Academic Article Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice.
Academic Article Scattering differentiates Alzheimer disease in vitro.
Academic Article Protective effects of NSAIDs on the development of Alzheimer disease.
Academic Article Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral sclerosis.
Academic Article Peduncular hallucinosis associated with isolated infarction of the substantia nigra pars reticulata.
Academic Article p75NTR antagonistic cyclic peptide decreases the size of beta amyloid-induced brain inflammation.
Academic Article Substance P immunoreactive astrocytes are present in multiple sclerosis plaques.
Academic Article Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha).
Academic Article Motor neuronal protection by L-arginine prolongs survival of mutant SOD1 (G93A) ALS mice.
Academic Article Along the way to a neurofibrillary tangle: a look at the structure of tau.
Academic Article Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice.
Academic Article Anti-inflammatory treatment in AD mice protects against neuronal pathology.
Academic Article Moderate exercise delays the motor performance decline in a transgenic model of ALS.
Academic Article Aluminum-induced neurofibrillary degeneration affects a subset of neurons in rabbit cerebral cortex, basal forebrain and upper brainstem.
Academic Article TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
Academic Article Differential expression of c-Ret in motor neurons versus non-neuronal cells is linked to the pathogenesis of ALS.
Academic Article Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
Academic Article Somatostatin: alterations in the central nervous system in neurological diseases.
Academic Article Neuropeptide Y, somatostatin, and reduced nicotinamide adenine dinucleotide phosphate diaphorase in the human striatum: a combined immunocytochemical and enzyme histochemical study.
Academic Article Tyrosine hydroxylase-like immunoreactivity is distributed in the matrix compartment of normal human and Huntington''s disease striatum.
Academic Article Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice.
Academic Article Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: normal anatomy and alterations in Alzheimer's disease.
Academic Article Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease.
Academic Article Antibiotics and mortality in patients with lower respiratory infection and advanced dementia.
Academic Article Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Academic Article Memantine for posttraumatic stress disorder in an older veteran.
Academic Article Morphology and distribution of nicotinamide adenine dinucleotide phosphate (reduced form) diaphorase reactive neurons in human brainstem.
Academic Article ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.
Academic Article Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.
Academic Article Neuropathologic, neurochemical and immunocytochemical characteristics of aluminum-induced neurofilamentous degeneration.
Academic Article Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of ?-H2AX and DNA damage responses in Huntington's disease.
Academic Article Underuse of diagnostic codes for specific dementias in the Veterans Affairs New England healthcare system.
Academic Article Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.
Academic Article Novel late-onset Alzheimer disease loci variants associate with brain gene expression.
Academic Article Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
Academic Article Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease.
Academic Article Degeneration of pyramidal projection neurons in Huntington's disease cortex.
Academic Article Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer''s disease in the absence of apolipoprotein E4 allele.
Academic Article Clinical presentation of chronic traumatic encephalopathy.
Academic Article Expression of taurine transporter (TauT) is modulated by heat shock factor 1 (HSF1) in motor neurons of ALS.
Academic Article The spectrum of disease in chronic traumatic encephalopathy.
Academic Article An intervention to enhance Alzheimer''s disease clinical research participation among older African Americans.
Academic Article MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.
Academic Article The Department of Veterans Affairs Biorepository Brain Bank: a national resource for amyotrophic lateral sclerosis research.
Academic Article Patterns of cell loss in Huntington's disease. Trends in Neurosciences
Academic Article The Handbook of Alzheimer’s Disease and Other Dementias ISBN: 978-1-4051-6828-1
Academic Article Histochemical observations on neuronal degeneration, cytoskeletal reorganization and phosphorylation in Alzheimer's disease. Proceedings of the XIth Intl Congress of Neuropathology
Academic Article Underuse of Diagnostic Codes for Specific Dementias in the VA New England Health Care System. J Am Geriatr Soc
Academic Article Alterations of neuropeptide Y in neurological disorders
Academic Article Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid.
Academic Article Cytoarchitecture, fiber connections, and some histochemical aspects of the interpeduncular nucleus in the rat.
Academic Article A quantitative regional analysis of vascular amyloidosis in Alzheimer's disease. Proc VII Intl Symp on Amyloidosis
Academic Article Gilles de la Tourette's syndrome. A postmortem neuropathological and immunohistochemical study.
Academic Article Topography of enkephalin, substance P and acetylcholinesterase staining in Huntington's disease striatum.
Academic Article Individual cell types as targets of neural disease processes in Huntington's disease
Academic Article Neuropeptides in Alzheimer's disease.
Academic Article Striatal degeneration and neuronal sparing in Huntington's disease, Butterworths
Academic Article Systemic approaches to modifying quinolinic acid striatal lesions in rats.
Academic Article The Neuropathology of Huntington’s Disease
Academic Article Inability of ß-amyloid (ß(25-35)) to bind to central nervous system neurokinin 1 receptors. Drug Dev Res
Academic Article Galanin-like immunoreactivity is present in human substantia innominata and in senile plaques in Alzheimer's disease.
Academic Article Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions.
Academic Article Neurochemical characteristics of aluminum-induced neurofibrillary degeneration in rabbits.
Academic Article Case Records of the Massachusetts General Hospital (Case 7-88). NEJM
Academic Article Some observations on the significance of neurotransmitter changes in Alzheimer Disease
Academic Article The histopathology of neuronal degeneration and plasticity in Alzheimer's disease
Academic Article Mechanisms of neuronal degeneration in Huntington's disease
Academic Article Neuropathology of Huntington's disease-reply. Trends in Neurosciences
Academic Article Mitochondrial Dysfunction as a Model for Huntington's Disease Using the Electron Transport Chain Inhibitor, 3-Nitropropionic Acid
Academic Article Neuronal plasticity: a potential role in spiny striatal neuron degeneration in Huntington's disease
Academic Article How tight is the connection between synapse loss and clinical dementia? Neurobiol Aging
Academic Article Microtubular reorganization and dendritic growth response in Alzheimer's disease.
Academic Article Corticotropin-releasing factor immunoreactive neurons persist throughout the brain in Alzheimer's disease.
Academic Article Topography of nicotinamide adenine dinucleotide phosphate-diaphorase staining neurons in rat striatum.
Academic Article Selective sparing of a class of striatal neurons in Huntington's disease.
Academic Article Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease.
Academic Article Sparing of acetylcholinesterase-containing striatal neurons in Huntington's disease.
Academic Article Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease.
Academic Article Results of immunocytochemical, neurochemical, and behavioral studies in aluminum-induced neurofilamentous degeneration.
Academic Article Subset of neurons characterized by the presence of NADPH-diaphorase in human substantia innominata.
Academic Article A current look at feline lymphoma.
Academic Article The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortex.
Academic Article Senile plaques are located between apical dendritic clusters.
Academic Article Neurofilament and neural cell adhesion molecule immunocytochemistry of Huntington's disease striatum.
Academic Article Involvement of free radicals in excitotoxicity in vivo.
Academic Article Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase.
Academic Article Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid.
Academic Article Substance P and substance P receptor histochemistry in human neurodegenerative diseases.
Academic Article Myocyte-specific enhancer binding factor 2C expression in human brain development.
Academic Article Beta amyloid neurotoxicity and neuronal degeneration in Alzheimer's disease.
Academic Article Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene.
Academic Article A frequent ala 4 to val superoxide dismutase-1 mutation is associated with a rapidly progressive familial amyotrophic lateral sclerosis.
Academic Article Pretreatment with intraventricular basic fibroblast growth factor decreases infarct size following focal cerebral ischemia in rats.
Academic Article Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele.
Academic Article Vitamin E and memantine in Alzheimer''s disease: clinical trial methods and baseline data.
Academic Article Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer''s disease.
Academic Article 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis.
Academic Article GABA from reactive astrocytes impairs memory in mouse models of Alzheimer''s disease.
Academic Article The source of cognitive complaints predicts diagnostic conversion differentially among nondemented older adults.
Academic Article Nucleolar dysfunction in Huntington''s disease.
Academic Article A multifunctional protein EWS regulates the expression of Drosha and microRNAs.
Academic Article ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription.
Academic Article Beta-amyloid deposition in chronic traumatic encephalopathy.
Academic Article Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency.
Academic Article R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer''s disease.
Academic Article Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Academic Article Combination therapy in a transgenic model of Alzheimer''s disease.
Academic Article Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
Academic Article Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study.
Academic Article Epigenetic mechanisms of neurodegeneration in Huntington''s disease.
Academic Article Epigenetic mechanisms of Rubinstein-Taybi syndrome.
Academic Article Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial.
Academic Article Destruction of white matter integrity in patients with mild cognitive impairment and Alzheimer disease.
Academic Article Inclusion of an informant yields strong associations between cognitive complaint and longitudinal cognitive outcomes in non-demented elders.
Academic Article Proteomic analysis reveals differentially regulated protein acetylation in human amyotrophic lateral sclerosis spinal cord.
Academic Article Therapeutic targeting of epigenetic components in amyotrophic lateral sclerosis (ALS).
Academic Article Screening Utility of the King-Devick Test in Mild Cognitive Impairment and Alzheimer Disease Dementia.
Academic Article Mini Mental State Examination and Logical Memory scores for entry into Alzheimer''s disease trials.
Academic Article Cognitive Reserve as a Modifier of Clinical Expression in Chronic Traumatic Encephalopathy: A Preliminary Examination.
Academic Article Predicting mortality in patients treated differently: updating and external validation of a prediction model for nursing home residents with dementia and lower respiratory infections.
Academic Article Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer''s disease.
Academic Article Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer''s Disease Mouse Model.
Academic Article Amylin receptor ligands reduce the pathological cascade of Alzheimer''s disease.
Academic Article Modeling the Relationships Among Late-Life Body Mass Index, Cerebrovascular Disease, and Alzheimer''s Disease Neuropathology in an Autopsy Sample of 1,421 Subjects from the National Alzheimer''s Coordinating Center Data Set.
Academic Article An amylin analog used as a challenge test for Alzheimer''s disease.
Academic Article Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy.
Grant Superoxide Dismutase in Aging and Neurodegeneration
Grant Alpha Synuclein Aggregation in a Neurotoxic Model of Parkinson’s Disease
Grant Role of Somatic mtDNA Mutations 0n Neurodegeneration
Grant The Role of Superoxide Dismutase in Aging and Neurodegeneration
Grant A Transgenic Model of Oxidative Damage in Schizophrenia
Academic Article Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington''s disease.
Academic Article The Effect of Traumatic Brain Injury History with Loss of Consciousness on Rate of Cognitive Decline Among Older Adults with Normal Cognition and Alzheimer''s Disease Dementia.
Academic Article Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer''s disease.
Academic Article Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football.
Academic Article VA''s National PTSD Brain Bank: a National Resource for Research.
Academic Article Clinical Utility of Select Neuropsychological Assessment Battery Tests in Predicting Functional Abilities in Dementia.
Academic Article SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer''s disease.
Academic Article Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
Academic Article Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer''s Disease.
Academic Article Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.
Academic Article Age of first exposure to tackle football and chronic traumatic encephalopathy.
Academic Article A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer''s Disease Neuropathology.
Academic Article Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports.
Academic Article Chronic Traumatic Encephalopathy Within an Amyotrophic Lateral Sclerosis Brain Bank Cohort.
Academic Article Variation in TMEM106B in chronic traumatic encephalopathy.
Academic Article EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways.
Academic Article Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article Failure to detect an association between self-reported traumatic brain injury and Alzheimer''s disease neuropathology and dementia.
Academic Article A magnetic resonance spectroscopy investigation in symptomatic former NFL players.
Academic Article Vasoactive Intestinal Peptide Decreases ß-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer''s Disease.
Academic Article Contact sport participation and chronic traumatic encephalopathy are associated with altered severity and distribution of cerebral amyloid angiopathy.
Academic Article Quantitative Proteomic Analysis Reveals Impaired Axonal Guidance Signaling in Human Postmortem Brain Tissues of Chronic Traumatic Encephalopathy.
Academic Article Metabolomic Analysis Identifies Alterations of Amino Acid Metabolome Signatures in the Postmortem Brain of Alzheimer''s Disease.
Academic Article Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer''s Coordinating Center Uniform Data Set.
Academic Article Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer''s disease.
Academic Article Association of White Matter Rarefaction, Arteriolosclerosis, and Tau With Dementia in Chronic Traumatic Encephalopathy.
Academic Article Author Correction: Genetic meta-analysis of diagnosed Alzheimer''s disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing.
Academic Article Duration of American Football Play and Chronic Traumatic Encephalopathy.
Academic Article Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson''s Disease.
Grant National Alzheimer's Coordinating Center (NACC) Yr4/5
Grant Boston University Alzheimer Disease Core Center
Academic Article Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy.
Academic Article Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer''s disease.
Academic Article Alterations of transcriptome signatures in head trauma-related neurodegenerative disorders.
Academic Article A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer''s disease.
Academic Article Neuropathological profile of long-duration amyotrophic lateral sclerosis in military Veterans.
Academic Article Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme.
Academic Article Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy.
Academic Article Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.
Grant Alzheimer's Disease Translational Research Training
Grant Multi-center development of a novel diagnostic test for Alzheimer's disease
Grant Boston University Alzheimer's Disease Core Center
Grant Boston University Alzheimer's Disease Core Center
Grant Alzheimer's Disease Neuroimaging Initiative
Grant Genome Wide Association Analysis of Alzheimer's Disease
Grant National Alzheimer's Coordinating Center (NACC)
Grant Alzheimer's Disease Neuroimaging Initiative
Grant Boston University Alzheimer's Disease Center
Grant National Alzheimer's Coordinating Center (NACC)
Grant National Alzheimer's Coordinating Center (NACC)
Grant Alzheimer's Disease Neuroimaging INitiative Grand Opportunity
Grant Boston University Alzheimer's Disease Center
Grant Personnel Agreement for Research Services of Junghee Lee
Academic Article Revised Framingham Stroke Risk Profile: Association with Cognitive Status and MRI-Derived Volumetric Measures.

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