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Search Results to Sam Thiagalingam, PhD

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One or more keywords matched the following properties of Thiagalingam, Sam

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Research Expertise & Professional Interests Dr. Thiagalingam is an expert cancer geneticist and was the first to show that SMAD4 inactivation is a critical event during the late stages of colon cancer progression. He was a lead researcher in the team that first identified a family of five novel SMAD genes. He also proposed a simple minded multi-modular molecular network (MMMN) cancer progression model as a road map to visualize the various gene alterations in modules of networks of pathways. Recently, his studies found that intact hyperactive TGFß-Smad signaling is required to sustain “epigenetic memory” responsible for epithelial-mesenchymal transition (EMT), a critical step during conversion to malignant cancer. His long-term goal is to identify novel cancer biomarkers and therapeutic targets by contributing to the “big picture” of interconnected network of events that mediate cancer progression to metastasis using breast and colon cancers as the model systems.
Self-Described Keywords Epigenetics

One or more keywords matched the following items that are connected to Thiagalingam, Sam

Item TypeName
Concept Epigenomics
Academic Article Histone deacetylases: unique players in shaping the epigenetic histone code.
Academic Article Elucidation of epigenetic inactivation of SMAD8 in cancer using targeted expressed gene display.
Academic Article Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope.
Academic Article Epigenetic alterations of the dopaminergic system in major psychiatric disorders.
Academic Article Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics.
Academic Article Smad signaling is required to maintain epigenetic silencing during breast cancer progression.
Academic Article Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder.
Academic Article DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder.
Academic Article Can the schizophrenia epigenome provide clues for the molecular basis of pathogenesis?
Academic Article An update on the epigenetics of psychotic diseases and autism.
Academic Article Methamphetamine-induced psychosis is associated with DNA hypomethylation and increased expression of AKT1 and key dopaminergic genes.
Grant Epigenetic Modulation of Serotonin Signaling in the Pathogenesis of Schizophrenia and Bipolar Disorder
Academic Article Epigenetic memory in development and disease: Unraveling the mechanism.

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  • Epigenetics