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Search Results to Sam Thiagalingam, PhD

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One or more keywords matched the following properties of Thiagalingam, Sam

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Research Expertise & Professional Interests Dr. Thiagalingam is an expert cancer geneticist and was the first to show that SMAD4 inactivation is a critical event during the late stages of colon cancer progression. He was a lead researcher in the team that first identified a family of five novel SMAD genes. He also proposed a simple minded multi-modular molecular network (MMMN) cancer progression model as a road map to visualize the various gene alterations in modules of networks of pathways. Recently, his studies found that intact hyperactive TGFß-Smad signaling is required to sustain “epigenetic memory” responsible for epithelial-mesenchymal transition (EMT), a critical step during conversion to malignant cancer. His long-term goal is to identify novel cancer biomarkers and therapeutic targets by contributing to the “big picture” of interconnected network of events that mediate cancer progression to metastasis using breast and colon cancers as the model systems.
Self-Described Keywords Cancer genetics
Self-Described Keywords cancer metastasis
Self-Described Keywords Epigenetics

One or more keywords matched the following items that are connected to Thiagalingam, Sam

Item TypeName
Concept Brain Neoplasms
Concept Breast Neoplasms
Concept Colonic Neoplasms
Concept Esophageal Neoplasms
Concept Head and Neck Neoplasms
Concept Lung Neoplasms
Concept Neoplasms
Concept Ovarian Neoplasms
Concept Pancreatic Neoplasms
Concept Prostatic Neoplasms
Concept Stomach Neoplasms
Concept Colorectal Neoplasms
Concept Epigenomics
Concept Triple Negative Breast Neoplasms
Academic Article Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.
Academic Article Mad-related genes in the human.
Academic Article Evaluation of the FHIT gene in colorectal cancers.
Academic Article Frequency of Smad gene mutations in human cancers.
Academic Article 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression.
Academic Article Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers.
Academic Article Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line.
Academic Article Mechanisms underlying losses of heterozygosity in human colorectal cancers.
Academic Article Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence.
Academic Article Histone deacetylases: unique players in shaping the epigenetic histone code.
Academic Article Elucidation of epigenetic inactivation of SMAD8 in cancer using targeted expressed gene display.
Academic Article Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer.
Academic Article Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer.
Academic Article Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope.
Academic Article A cascade of modules of a network defines cancer progression.
Academic Article Aberrant activation of gamma-catenin promotes genomic instability and oncogenic effects during tumor progression.
Academic Article Epigenetic alterations of the dopaminergic system in major psychiatric disorders.
Academic Article Epigenetic and pharmacoepigenomic studies of major psychoses and potentials for therapeutics.
Academic Article hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells.
Academic Article hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation.
Academic Article Smad signaling is required to maintain epigenetic silencing during breast cancer progression.
Academic Article Smad4 inactivation promotes malignancy and drug resistance of colon cancer.
Academic Article Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder.
Academic Article DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder.
Academic Article Can the schizophrenia epigenome provide clues for the molecular basis of pathogenesis?
Academic Article Integrin signaling in mammary epithelial cells and breast cancer.
Academic Article An update on the epigenetics of psychotic diseases and autism.
Academic Article Methamphetamine-induced psychosis is associated with DNA hypomethylation and increased expression of AKT1 and key dopaminergic genes.
Academic Article Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis.
Academic Article Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells.
Academic Article SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis.
Grant Metastatic Progression of Breast Cancer by Allelic Loss on Chromosome 18q21
Grant Identification and Functional Characterization of Novel Genes Involved in Breast Cancer Metastasis
Grant Epigenetic Modulation of Serotonin Signaling in the Pathogenesis of Schizophrenia and Bipolar Disorder
Academic Article Activin A Signaling Regulates IL13Ra2 Expression to Promote Breast Cancer Metastasis.
Academic Article MicroRNA-4417 is a tumor suppressor and prognostic biomarker for triple-negative breast cancer.
Academic Article Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.
Academic Article Epigenetic memory in development and disease: Unraveling the mechanism.
Award or Honor Receipt Carter Award for Diversity and Cancer Equity
Grant Identification and functional characterization of novel genes involved in breast cancer metastasis
Grant Dissecting the metastasis suppressor complex to identify colon cancer biomarkers

Highlights
Search Criteria
  • Epigenetic
  • therapies
  • cancer