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Research Expertise & Professional Interests My laboratory research to date has focused on the design, cloning, production, and use of lentiviruses in vitro and in vivo to overexpress or knock down gene expression, particularly in alveolar macrophages and stem cell populations, and using lentiviruses to develop a gene therapy for alpha-1 antitrypsin deficiency. I have approached this problem through the manipulation of two target cell populations: hematopoietic stem cells and alveolar macrophages. Both approaches have resulted in long-term expression of human alpha-1 antitrypsin in laboratory animals. In addition to the in-vivo overexpression of alpha-1 antitrypsin, I am interested in manipulating other genes which may play a role in the pathogenesis of COPD, such as NF-kB. A second area of interest is embryonic stem cell biology. I am working with Darrell Kotton and others in our division to study the progression of definitive endoderm to lung epithelium. Research interests include: -Alpha-1 antitrypsin deficiency -gene therapy -alveolar macrophage biology -embryonic stem cells Clinical interests include: -Critical Care Medicine -Tuberculosis
Self-Described Keywords gene therapy

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  • gene
  • over
  • expression