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Search Results to Alexa Beiser, PhD

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Research Expertise & Professional Interests Alexa Beiser has been on the faculty at Boston University School of Public Health since 1985, engaged in teaching and collaborative public health research; she co-developed the doctoral program in biostatistics; co-directed the biostatistics program from 2000-2004, and served as Associate Chair for Education from 2015-2018. She formerly taught and coordinated the sections of Introduction to Statistical Computing. For more than twenty-five years, Dr. Beiser has served as the lead biostatistician for the Framingham Heart Study (FHS) neurology group, examining risk factors and prevalence and incidence of clinical and sub-clinical neurological outcomes including MRI and PET measures of brain structure, cognitive performance, dementia, Alzheimer’s disease, stroke, Parkinson’s disease, and epilepsy. Dr. Beiser currently leads the FHS neurology group data management team, responsible for surveillance and tracking of incident dementia, for supervision of recruitment of participants for various grant-funded studies, and for management of data collected at FHS as well as those measured or processed at other institutions (e.g., brain MRI or PET scans); and the FHS neurology group biostatistics team of six biostatisticians. Decades of examining risk factors for neurological diseases has naturally led to studying factors associated with accelerated brain aging. Dr. Beiser has coauthored FHS publications relating risk factors including midlife vascular factors, plasma homocysteine, plasma leptin levels, cardiac index, red blood cell omega-3 fatty acids, metabolic dysregulation, visceral fat, air pollution; serum brain-derived neurotrophic factor; and insulin-like growth factor 1, to measures of brain aging. Dr. Beiser also has made use of the richness of the multigenerational Framingham data to relate documented parental dementia and stroke to offspring stroke, cognitive performance, and MRI measures of brain structure. In investigations of clinical neurological endpoints, she has applied competing risk analyses and has also been able to investigate temporal trends in prevalent and incident neurological disease due to the availability of event surveillance over many decades. In all these studies, Dr. Beiser plays a key role in project conceptualization, is responsible for supervision of statistical data management, analysis, and interpretation of results, and contributes to manuscript preparation and critical review.

One or more keywords matched the following items that are connected to Beiser, Alexa

Item TypeName
Concept Dementia
Concept Dementia, Vascular
Academic Article Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study.
Academic Article Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study.
Academic Article Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia.
Academic Article Plasma homocysteine as a risk factor for dementia and Alzheimer's disease.
Academic Article Central auditory dysfunction may precede the onset of clinical dementia in people with probable Alzheimer's disease.
Academic Article Dementia after stroke: the Framingham Study.
Academic Article The lifetime risk of stroke: estimates from the Framingham Study.
Academic Article Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study.
Academic Article No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies.
Academic Article Association of parental dementia with cognitive and brain MRI measures in middle-aged adults.
Academic Article Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging.
Academic Article Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study.
Academic Article Depressive symptoms and risk of dementia: the Framingham Heart Study.
Academic Article Biomarkers for insulin resistance and inflammation and the risk for all-cause dementia and alzheimer disease: results from the Framingham Heart Study.
Academic Article The Framingham Brain Donation Program: neuropathology along the cognitive continuum.
Academic Article Red blood cell ?-3 fatty acid levels and markers of accelerated brain aging.
Academic Article Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Academic Article Lexical retrieval in discourse: an early indicator of Alzheimer''s dementia.
Academic Article Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study.
Academic Article Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia.
Academic Article COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.
Academic Article Parental longevity is associated with cognition and brain ageing in middle-aged offspring.
Academic Article Development and validation of a brief dementia screening indicator for primary care.
Academic Article Gender and incidence of dementia in the Framingham Heart Study from mid-adult life.
Academic Article Verbal memory and brain aging: an exploratory analysis of the role of error responses in the Framingham Study.
Academic Article Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging.
Academic Article Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy.
Academic Article Low cardiac index is associated with incident dementia and Alzheimer disease: the Framingham Heart Study.
Academic Article Neuropsychological Criteria for Mild Cognitive Impairment and Dementia Risk in the Framingham Heart Study.
Academic Article Incidence of Dementia over Three Decades in the Framingham Heart Study.
Academic Article Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study.
Academic Article Plasma clusterin levels and risk of dementia, Alzheimer's disease, and stroke.
Academic Article Interarm differences in systolic blood pressure and the risk of dementia and subclinical brain injury.
Academic Article Association of Serum Vitamin D with the Risk of Incident Dementia and Subclinical Indices of Brain Aging: The Framingham Heart Study.
Academic Article Incidence of Dementia over Three Decades in the Framingham Heart Study.
Academic Article Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study.
Academic Article Association of Ideal Cardiovascular Health With Vascular Brain Injury and Incident Dementia.
Academic Article Aortic Stiffness and the Risk of Incident Mild Cognitive Impairment and Dementia.
Academic Article Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.
Academic Article Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study.
Academic Article Cerebral microbleeds and risk of incident dementia: the Framingham Heart Study.
Academic Article APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.
Academic Article The changing prevalence and incidence of dementia over time - current evidence.
Academic Article Association of amine biomarkers with incident dementia and Alzheimer''s disease in the Framingham Study.
Academic Article Response by Pase et al to Letters Regarding Article, "Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia. A Prospective Cohort Study".
Academic Article Sleep architecture and the risk of incident dementia in the community.
Academic Article Author response: Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia.
Academic Article Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia.
Academic Article Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium.
Academic Article Blood pressure from mid- to late life and risk of incident dementia.
Academic Article Author response: Sleep architecture and the risk of incident dementia in the community.
Academic Article Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer''s disease: A prospective study in eight cohorts.
Academic Article Are Trends in Dementia Incidence Associated With Compression in Morbidity? Evidence From The Framingham Heart Study.
Academic Article Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer''s disease: Pooled analysis from 5 cohorts.
Academic Article Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer''s Disease Associates with Increased Odds for Brain Infarcts.
Academic Article Circulating fibroblast growth factor 23 levels and incident dementia: The Framingham heart study.
Academic Article Assessment of Plasma Total Tau Level as a Predictive Biomarker for Dementia and Related Endophenotypes.
Academic Article Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume: The Framingham Heart Study.
Academic Article Circulating IGFBP-2: a novel biomarker for incident dementia.
Academic Article Antihypertensive medications and risk for incident dementia and Alzheimer''s disease: a meta-analysis of individual participant data from prospective cohort studies.
Academic Article Association of CD14 with incident dementia and markers of brain aging and injury.
Academic Article Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia.
Academic Article Circulating ceramide ratios and risk of vascular brain aging and dementia.
Academic Article The progression of carotid atherosclerosis and imaging markers of dementia.
Academic Article Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.
Academic Article Cardiovascular health, genetic risk, and risk of dementia in the Framingham Heart Study.
Academic Article Systemic Inflammation as a Moderator Between Sleep and Incident Dementia.
Academic Article Growth Differentiation Factor 15 and NT-proBNP as Blood-Based Markers of Vascular Brain Injury and Dementia.
Academic Article The bi-directional association between epilepsy and dementia. The Framingham Heart Study.

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Search Criteria
  • Dementias