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Research Expertise & Professional Interests My expertise is in protein structure, function, dynamics and folding and chemistry. Methods used include molecular biology, chromatography, NMR spectroscopy, X-ray crystallography, UV/Vis and circular dichroism spectroscopy, electron microscopy, molecular modeling and dynamics. We look at actin binding proteins (especially those containing villin-type headpiece domains) and lipid binding proteins including apolipoprotein B, the essential protein component of low density lipoprotein (LDL, the bad cholesterol) whose elevated levels are correlated with atherosclerosis, stroke, heart and cardiovascular disease.

One or more keywords matched the following items that are connected to McKnight, C.

Item TypeName
Concept Bacterial Outer Membrane Proteins
Concept Bacterial Proteins
Concept Blood Proteins
Concept Calcium-Binding Proteins
Concept Carrier Proteins
Concept DNA-Binding Proteins
Concept Egg Proteins
Concept Fungal Proteins
Concept Membrane Proteins
Concept Microfilament Proteins
Concept Models, Structural
Concept Protein Binding
Concept Protein Conformation
Concept Protein Denaturation
Concept Protein Kinases
Concept Protein Processing, Post-Translational
Concept Proteins
Concept Recombinant Fusion Proteins
Concept Recombinant Proteins
Concept Repressor Proteins
Concept Salivary Proteins and Peptides
Concept Structure-Activity Relationship
Concept Protein Biosynthesis
Concept Viral Proteins
Concept Protein Engineering
Concept Egg Proteins, Dietary
Concept Molecular Structure
Concept Protozoan Proteins
Concept Neurofilament Proteins
Concept Cyclic AMP Response Element-Binding Protein
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Protein Folding
Concept Cyclic AMP-Dependent Protein Kinases
Concept Protein Isoforms
Concept Protein Structure, Quaternary
Concept Protein Transport
Concept Protein Sorting Signals
Concept Arabidopsis Proteins
Concept Saccharomyces cerevisiae Proteins
Concept Avian Proteins
Concept Structural Homology, Protein
Concept Mutant Proteins
Concept Viral Regulatory and Accessory Proteins
Concept Protein Interaction Domains and Motifs
Concept Protein Multimerization
Concept Protein Stability
Academic Article A thermostable 35-residue subdomain within villin headpiece.
Academic Article NMR structure of the 35-residue villin headpiece subdomain.
Academic Article Evolution of a protein fold in vitro.
Academic Article NMR structure of an F-actin-binding "headpiece" motif from villin.
Academic Article Zinc and copper bind to unique sites of histatin 5.
Academic Article An evolutionary bridge to a new protein fold.
Academic Article The N-terminal 17% of apoB binds tightly and irreversibly to emulsions modeling nascent very low density lipoproteins.
Academic Article The role of aromatic residues in the hydrophobic core of the villin headpiece subdomain.
Academic Article Villin-type headpiece domains show a wide range of F-actin-binding affinities.
Academic Article Temperature-dependent dynamics of the villin headpiece helical subdomain, an unusually small thermostable protein.
Academic Article A novel nontruncating APOB gene mutation, R463W, causes familial hypobetalipoproteinemia.
Academic Article Solution structure of switch Arc, a mutant with 3(10) helices replacing a wild-type beta-ribbon.
Academic Article Dynamic NMR line-shape analysis demonstrates that the villin headpiece subdomain folds on the microsecond time scale.
Academic Article The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site.
Academic Article High-resolution crystal structures of villin headpiece and mutants with reduced F-actin binding activity.
Academic Article Limited proteolysis and biophysical characterization of the lipovitellin homology region in apolipoprotein B.
Academic Article Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain.
Academic Article Multistate folding of the villin headpiece domain.
Academic Article Networking at the Protein Society symposium.
Academic Article A phosphorylation-induced conformation change in dematin headpiece.
Academic Article Defining lipid-interacting domains in the N-terminal region of apolipoprotein B.
Academic Article Structural analysis of reconstituted lipoproteins containing the N-terminal domain of apolipoprotein B.
Academic Article Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial hypobetalipoproteinemia.
Academic Article Fluorescence analysis of tryptophan-containing variants of the LamB signal sequence upon insertion into a lipid bilayer.
Academic Article Conformational and membrane-binding properties of a signal sequence are largely unaltered by its adjacent mature region.
Academic Article The differential impact of disulfide bonds and N-linked glycosylation on the stability and function of CD14.
Academic Article The isolated sixth gelsolin repeat and headpiece domain of villin bundle F-actin in the presence of calcium and are linked by a 40-residue unstructured sequence.
Academic Article Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
Academic Article Biophysical studies of signal peptides: implications for signal sequence functions and the involvement of lipid in protein export.
Academic Article Crystal structure of a pH-stabilized mutant of villin headpiece.
Academic Article Phosphorylation-induced changes in backbone dynamics of the dematin headpiece C-terminal domain.
Academic Article Interfacial properties of a complex multi-domain 490 amino acid peptide derived from apolipoprotein B (residues 292-782).
Academic Article Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain.
Academic Article Reconstituting initial events during the assembly of apolipoprotein B-containing lipoproteins in a cell-free system.
Academic Article Sequence-specific DNA binding by a short peptide dimer.
Academic Article Slow motions in chicken villin headpiece subdomain probed by cross-correlated NMR relaxation of amide NH bonds in successive residues.
Academic Article A novel missense HGD gene mutation, K57N, in a patient with alkaptonuria.
Academic Article Heterogeneity and dynamics in villin headpiece crystal structures.
Academic Article How to arm a supervillin: designing F-actin binding activity into supervillin headpiece.
Academic Article Conformations and orientations of a signal peptide interacting with phospholipid monolayers.
Academic Article Molecular model of the microvillar cytoskeleton and organization of the brush border.
Academic Article Functional and nonfunctional LamB signal sequences can be distinguished by their biophysical properties.
Academic Article Identifying competitive protein antagonists for F-actin with reverse-phase high-performance liquid chromatography.
Academic Article Nonsynonymous mutations within APOB in human familial hypobetalipoproteinemia: evidence for feedback inhibition of lipogenesis and postendoplasmic reticulum degradation of apolipoprotein B.
Academic Article Interfacial properties of apolipoprotein B292-593 (B6.4-13) and B611-782 (B13-17). Insights into the structure of the lipovitellin homology region in apolipoprotein B.
Academic Article On unsatisfied hydrogen bonds in the N-terminal subdomain of villin headpiece.
Academic Article Competition between intradomain and interdomain interactions: a buried salt bridge is essential for villin headpiece folding and actin binding.
Academic Article On the unyielding hydrophobic core of villin headpiece.
Academic Article Identification of a specific region of Plasmodium falciparum EBL-1 that binds to host receptor glycophorin B and inhibits merozoite invasion in human red blood cells.
Academic Article The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9).
Academic Article IcmQ in the Type 4b secretion system contains an NAD+ binding domain.
Academic Article Helix formation and stability in a signal sequence.
Academic Article Minimum length of a sequence-specific DNA binding peptide.
Academic Article Surface tensiometry of apolipoprotein B domains at lipid interfaces suggests a new model for the initial steps in triglyceride-rich lipoprotein assembly.
Academic Article The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9).
Academic Article Gelsolin-like activation of villin: calcium sensitivity of the long helix in domain 6.
Academic Article The unusual internal motion of the villin headpiece subdomain.
Academic Article The Physiological Molecular Shape of Spectrin: A Compact Supercoil Resembling a Chinese Finger Trap.
Academic Article Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target.
Academic Article Combined Molecular Dynamics Simulations and Experimental Studies of the Structure and Dynamics of Poly-Amido-Saccharides.
Award or Honor Receipt Elected to the Nominating Committee of The Protein Society
Academic Article Optimized purification of a fusion protein by reversed-phase high performance liquid chromatography informed by the linear solvent strength model.
Academic Article Plant Villin Headpiece Domain Demonstrates a Novel Surface Charge Pattern and High Affinity for F-Actin.
Award or Honor Receipt Symposium Organizer for the 25th Anniversary Protein Society Symposium
Academic Article Deuteration of nonexchangeable protons on proteins affects their thermal stability, side-chain dynamics, and hydrophobicity.

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