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Search Results to Tsuneya Ikezu, MD, PhD

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Research Expertise & Professional Interests My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.
Self-Described Keywords synuclein
Self-Described Keywords Neural stem cells
Self-Described Keywords Alzheimer's disease
Self-Described Keywords Spatial learning

One or more keywords matched the following items that are connected to Ikezu, Tsuneya

Item TypeName
Concept Acquired Immunodeficiency Syndrome
Concept Alzheimer Disease
Concept Amino Acid Sequence
Concept Base Sequence
Concept Cell Survival
Concept Cell-Free System
Concept Central Nervous System
Concept Sterol Esterase
Concept Crohn Disease
Concept Disease Models, Animal
Concept Down Syndrome
Concept Extracellular Space
Concept Health Status
Concept Mice, Mutant Strains
Concept Molecular Sequence Data
Concept Motor Skills
Concept Nervous System Diseases
Concept Synaptic Transmission
Concept Organ Specificity
Concept Parkinson Disease
Concept Psychiatric Status Rating Scales
Concept Receptors, Cell Surface
Concept Regulatory Sequences, Nucleic Acid
Concept Retrospective Studies
Concept Schizophrenia
Concept Serine
Concept Severity of Illness Index
Concept Skin
Concept Spatial Behavior
Concept Mass Spectrometry
Concept Spinal Cord
Concept Stem Cells
Concept Stereoisomerism
Concept Stilbenes
Concept Structure-Activity Relationship
Concept Styrenes
Concept Subacute Sclerosing Panencephalitis
Concept Substantia Nigra
Concept Superoxides
Concept Supranuclear Palsy, Progressive
Concept Synapses
Concept Blotting, Southern
Concept Second Messenger Systems
Concept Cohort Studies
Concept Signal Transduction
Concept Case-Control Studies
Concept Genes, Retinoblastoma
Concept Free Radical Scavengers
Concept Genes, myc
Concept Sequence Alignment
Concept Mice, SCID
Concept Genes, fos
Concept Conserved Sequence
Concept Rats, Sprague-Dawley
Concept Protein-Serine-Threonine Kinases
Concept Reactive Oxygen Species
Concept Sequence Homology, Amino Acid
Concept Protein Structure, Secondary
Concept Oxidative Stress
Concept Disease Progression
Concept Muscle, Skeletal
Concept Statistics, Nonparametric
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept GTP-Binding Protein alpha Subunits, Gi-Go
Concept Genes, bcl-2
Concept Saquinavir
Concept Neurodegenerative Diseases
Concept Motor Skills Disorders
Concept Calcium Signaling
Concept Genetic Predisposition to Disease
Concept Terminal Repeat Sequences
Concept Polymorphism, Single Nucleotide
Concept Protein Structure, Quaternary
Concept Protein Subunits
Concept Amino Acid Transport System y+
Concept RNA, Small Interfering
Concept Intercellular Signaling Peptides and Proteins
Concept Serum
Concept Macromolecular Substances
Concept Intracellular Signaling Peptides and Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Regulatory Elements, Transcriptional
Concept GTP-Binding Protein alpha Subunit, Gi2
Concept Amyloid Precursor Protein Secretases
Concept Genome-Wide Association Study
Concept Insulin Receptor Substrate Proteins
Concept t-Complex Genome Region
Concept Induced Pluripotent Stem Cells
Concept Mice, 129 Strain
Concept Neural Stem Cells
Concept Transcriptome
Academic Article Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor.
Academic Article In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor.
Academic Article Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP.
Academic Article Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins.
Academic Article Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation.
Academic Article G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.
Academic Article Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms.
Academic Article Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types.
Academic Article A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury.
Academic Article Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex.
Academic Article Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein.
Academic Article Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain.
Academic Article Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.
Academic Article Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif.
Academic Article Transduction of bovine adrenal chromaffin cells using a recombinant adenovirus expressing GFP.
Academic Article C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease.
Academic Article Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity.
Academic Article Betagamma subunits mediate the NPY enhancement of ATP-stimulated inositol phosphate formation.
Academic Article OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis.
Academic Article Measurement of GTP gamma S binding to specific G proteins in membranes using G-protein antibodies.
Academic Article Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease.
Academic Article Molecular characterization of a putative antiretroviral transcriptional factor, OTK18.
Academic Article Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition.
Academic Article Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE).
Academic Article Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.
Academic Article OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions.
Academic Article Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.
Academic Article Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands.
Academic Article Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice.
Academic Article Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.
Academic Article Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis.
Academic Article Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes.
Academic Article OTK18 levels in plasma and cerebrospinal fluid correlate with viral load and CD8 T-cells in normal and AIDS patients.
Academic Article Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET.
Academic Article YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection.
Academic Article AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice.
Academic Article The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era.
Academic Article Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
Academic Article Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes.
Academic Article Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.
Academic Article CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice.
Academic Article Phenolic bis-styrylbenzenes as ß-amyloid binding ligands and free radical scavengers.
Academic Article Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum.
Academic Article AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice.
Academic Article The effect of HIV protease inhibitors on amyloid-ß peptide degradation and synthesis in human cells and Alzheimer's disease animal model.
Academic Article FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders.
Academic Article Characterization of insulin degrading enzyme and other amyloid-ß degrading proteases in human serum: a role in Alzheimer's disease?
Academic Article Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.
Academic Article The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain.
Academic Article Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.
Academic Article Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.
Academic Article The spectrum of disease in chronic traumatic encephalopathy.
Academic Article Huntington’s Disease
Academic Article Neurobiology and Neural Systems
Academic Article Alzheimer’s Disease
Academic Article Glial regulation of beta-amyloid deposition in transgenic animal models of Alzheimer's disease
Academic Article Neuropathogenesis of HIV
Academic Article Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.
Academic Article The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer''s disease.
Academic Article GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia.
Academic Article Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration.
Academic Article Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
Academic Article miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction.
Academic Article PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.
Academic Article Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy.
Academic Article Syk and Yea Shall Find.
Academic Article Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Academic Article Depletion of microglia and inhibition of exosome synthesis halt tau propagation.
Academic Article Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson''s disease.
Academic Article Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591].
Academic Article Occurrence of Crohn''s disease with Parkinson''s disease.
Academic Article AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, ß-amyloidosis, and Learning Impairment of APP/PS1 Mice.
Academic Article A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
Academic Article The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Academic Article Extracellular Vesicle Biology in Alzheimer''s Disease and Related Tauopathy.
Academic Article Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.
Academic Article Alzheimer''s Disease: The Role of Microglia in Brain Homeostasis and Proteopathy.
Award or Honor Receipt Jack Spivack Excellence in Neurosciences Award
Academic Article Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Academic Article TIA1 regulates the generation and response to toxic tau oligomers.
Academic Article Transcriptional and Epigenetic Regulation of Microglia in Health and Disease.
Academic Article Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
Academic Article Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease.
Academic Article Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.
Academic Article Emerging roles of extracellular vesicles in neurodegenerative disorders.
Academic Article Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy.
Academic Article Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra.
Academic Article Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing.
Academic Article Tau-tubulin kinase 1 and amyloid-ß peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models.
Academic Article Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids.
Academic Article Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities.
Academic Article Tau Secretion.
Academic Article Crohn''s and Parkinson''s Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo.
Academic Article Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses.
Academic Article Proteomic and biological profiling of extracellular vesicles from Alzheimer''s disease human brain tissues.
Academic Article P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice.
Academic Article Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer''s Disease Patients: A Pilot Study.
Grant Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease
Grant Evaluation of the effect of cell type-specific deletion of ESCRT genes on the spread of tau pathology
Grant Alzheimer Disease Genetic Architecture in African Americans
Grant Evaluation of STX6 silencing on the novel AAV-based PSP model
Grant Exosome-mediated Dissemination of Tau Aggregation in Alzheimer's Disease
Grant Therapeutic evaluation of novel tau kinase inhibitors in Alzheimer's disease
Grant Development of cell-based shRNA screening platform for targeting exosome pathway
Grant Alzheimer Disease Genetic Architecture in African Americans
Grant Validating TTBK1 as a target for Alzheimer’s disease
Grant Characterization of Microglial Signaling in Maternal Immune Activation-related Autism
Grant Eisai-Boston University Innovative Medicines for Alzheimer Disease and Dementia (EBiAD)
Grant Characterization of Microglial Signaling in Maternal Immune Activation-related Autism
Grant Target validation and development of drug discovery platform for TREM2/TYROBP signaling pathway modular
Grant Microglia and exosome-mediated tau spreading mechanism in Alzheimer's disease brain
Grant Identification of exosome signature in serum from ALS patients
Grant Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease
Grant Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease
Grant miRNA/STAT3 axis as a novel therapeutic target of Down Syndrome
Grant LRRK2 in the Immune System Program
Grant Characterization of Microglial Wnt Signaling in Maternal Immune Activation-Related Autism
Grant Characterization of Microglial Wnt Signaling in Maternal Immune Activation-Related Autism
Academic Article Alzheimer''s disease brain-derived extracellular vesicles spread tau pathology in interneurons.

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