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Search Results to Tsuneya Ikezu, MD, PhD

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Ikezu, Tsuneya

One or more keywords matched the following properties of Ikezu, Tsuneya

Property	Value
Research Expertise & Professional Interests	My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.
Self-Described Keywords	synuclein
Self-Described Keywords	Neural stem cells
Self-Described Keywords	Alzheimer's disease
Self-Described Keywords	Spatial learning

One or more keywords matched the following items that are connected to Ikezu, Tsuneya

Item Type	Name
Concept	Acquired Immunodeficiency Syndrome
Concept	Alzheimer Disease
Concept	Amino Acid Sequence
Concept	Base Sequence
Concept	Cell Survival
Concept	Cell-Free System
Concept	Central Nervous System
Concept	Sterol Esterase
Concept	Crohn Disease
Concept	Disease Models, Animal
Concept	Down Syndrome
Concept	Extracellular Space
Concept	Health Status
Concept	Mice, Mutant Strains
Concept	Molecular Sequence Data
Concept	Motor Skills
Concept	Nervous System Diseases
Concept	Synaptic Transmission
Concept	Organ Specificity
Concept	Parkinson Disease
Concept	Psychiatric Status Rating Scales
Concept	Receptors, Cell Surface
Concept	Regulatory Sequences, Nucleic Acid
Concept	Retrospective Studies
Concept	Schizophrenia
Concept	Serine
Concept	Severity of Illness Index
Concept	Skin
Concept	Spatial Behavior
Concept	Mass Spectrometry
Concept	Spinal Cord
Concept	Stem Cells
Concept	Stereoisomerism
Concept	Stilbenes
Concept	Structure-Activity Relationship
Concept	Styrenes
Concept	Subacute Sclerosing Panencephalitis
Concept	Substantia Nigra
Concept	Superoxides
Concept	Supranuclear Palsy, Progressive
Concept	Synapses
Concept	Blotting, Southern
Concept	Second Messenger Systems
Concept	Cohort Studies
Concept	Signal Transduction
Concept	Case-Control Studies
Concept	Genes, Retinoblastoma
Concept	Free Radical Scavengers
Concept	Genes, myc
Concept	Sequence Alignment
Concept	Mice, SCID
Concept	Genes, fos
Concept	Conserved Sequence
Concept	Rats, Sprague-Dawley
Concept	Protein-Serine-Threonine Kinases
Concept	Reactive Oxygen Species
Concept	Sequence Homology, Amino Acid
Concept	Protein Structure, Secondary
Concept	Oxidative Stress
Concept	Disease Progression
Concept	Muscle, Skeletal
Concept	Statistics, Nonparametric
Concept	Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept	GTP-Binding Protein alpha Subunits, Gi-Go
Concept	Genes, bcl-2
Concept	Saquinavir
Concept	Neurodegenerative Diseases
Concept	Motor Skills Disorders
Concept	Calcium Signaling
Concept	Genetic Predisposition to Disease
Concept	Terminal Repeat Sequences
Concept	Polymorphism, Single Nucleotide
Concept	Protein Structure, Quaternary
Concept	Protein Subunits
Concept	Amino Acid Transport System y+
Concept	RNA, Small Interfering
Concept	Intercellular Signaling Peptides and Proteins
Concept	Serum
Concept	Macromolecular Substances
Concept	Intracellular Signaling Peptides and Proteins
Concept	Adaptor Proteins, Signal Transducing
Concept	Regulatory Elements, Transcriptional
Concept	GTP-Binding Protein alpha Subunit, Gi2
Concept	Amyloid Precursor Protein Secretases
Concept	Genome-Wide Association Study
Concept	Insulin Receptor Substrate Proteins
Concept	t-Complex Genome Region
Concept	Induced Pluripotent Stem Cells
Concept	Mice, 129 Strain
Concept	Neural Stem Cells
Concept	Transcriptome
Academic Article	Conversion of G-protein specificity of insulin-like growth factor II/mannose 6-phosphate receptor by exchanging of a short region with beta-adrenergic receptor.
Academic Article	In vivo coupling of insulin-like growth factor II/mannose 6-phosphate receptor to heteromeric G proteins. Distinct roles of cytoplasmic domains and signal sequestration by the receptor.
Academic Article	Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP.
Academic Article	Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins.
Academic Article	Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation.
Academic Article	G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP.
Academic Article	Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms.
Academic Article	Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types.
Academic Article	A unique mechanism of desensitization to lipolysis mediated by beta(3)-adrenoceptor in rats with thermal injury.
Academic Article	Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex.
Academic Article	Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein.
Academic Article	Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain.
Academic Article	Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease.
Academic Article	Amino acids 356-372 constitute a Gi-activator sequence of the alpha 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif.
Academic Article	Transduction of bovine adrenal chromaffin cells using a recombinant adenovirus expressing GFP.
Academic Article	C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease.
Academic Article	Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity.
Academic Article	Betagamma subunits mediate the NPY enhancement of ATP-stimulated inositol phosphate formation.
Academic Article	OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis.
Academic Article	Measurement of GTP gamma S binding to specific G proteins in membranes using G-protein antibodies.
Academic Article	Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease.
Academic Article	Molecular characterization of a putative antiretroviral transcriptional factor, OTK18.
Academic Article	Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition.
Academic Article	Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE).
Academic Article	Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.
Academic Article	OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions.
Academic Article	Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.
Academic Article	Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands.
Academic Article	Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice.
Academic Article	Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.
Academic Article	Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis.
Academic Article	Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes.
Academic Article	OTK18 levels in plasma and cerebrospinal fluid correlate with viral load and CD8 T-cells in normal and AIDS patients.
Academic Article	Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET.
Academic Article	YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection.
Academic Article	AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice.
Academic Article	The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era.
Academic Article	Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
Academic Article	Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes.
Academic Article	Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.
Academic Article	CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice.
Academic Article	Phenolic bis-styrylbenzenes as ß-amyloid binding ligands and free radical scavengers.
Academic Article	Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum.
Academic Article	AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice.
Academic Article	The effect of HIV protease inhibitors on amyloid-ß peptide degradation and synthesis in human cells and Alzheimer's disease animal model.
Academic Article	FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders.
Academic Article	Characterization of insulin degrading enzyme and other amyloid-ß degrading proteases in human serum: a role in Alzheimer's disease?
Academic Article	Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.
Academic Article	The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain.
Academic Article	Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.
Academic Article	Pyroglutamate-3 amyloid-ß deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.
Academic Article	The spectrum of disease in chronic traumatic encephalopathy.
Academic Article	Huntington’s Disease
Academic Article	Neurobiology and Neural Systems
Academic Article	Alzheimer’s Disease
Academic Article	Glial regulation of beta-amyloid deposition in transgenic animal models of Alzheimer's disease
Academic Article	Neuropathogenesis of HIV
Academic Article	Bidirectional regulation of c-fos promoter by an oncogenic gip2 mutant of G alpha i2. A novel implication of retinoblastoma gene product.
Academic Article	The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer''s disease.
Academic Article	GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia.
Academic Article	Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration.
Academic Article	Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
Academic Article	miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction.
Academic Article	PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation.
Academic Article	Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy.
Academic Article	Syk and Yea Shall Find.
Academic Article	Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Academic Article	Depletion of microglia and inhibition of exosome synthesis halt tau propagation.
Academic Article	Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson''s disease.
Academic Article	Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591].
Academic Article	Occurrence of Crohn''s disease with Parkinson''s disease.
Academic Article	AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, ß-amyloidosis, and Learning Impairment of APP/PS1 Mice.
Academic Article	A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.
Academic Article	The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
Academic Article	Extracellular Vesicle Biology in Alzheimer''s Disease and Related Tauopathy.
Academic Article	Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.
Academic Article	Alzheimer''s Disease: The Role of Microglia in Brain Homeostasis and Proteopathy.
Award or Honor Receipt	Jack Spivack Excellence in Neurosciences Award
Academic Article	Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.
Academic Article	TIA1 regulates the generation and response to toxic tau oligomers.
Academic Article	Transcriptional and Epigenetic Regulation of Microglia in Health and Disease.
Academic Article	Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
Academic Article	Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease.
Academic Article	Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.
Academic Article	Emerging roles of extracellular vesicles in neurodegenerative disorders.
Academic Article	Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy.
Academic Article	Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra.
Academic Article	Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing.
Academic Article	Tau-tubulin kinase 1 and amyloid-ß peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models.
Academic Article	Assessment of separation methods for extracellular vesicles from human and mouse brain tissues and human cerebrospinal fluids.
Academic Article	Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities.
Academic Article	Tau Secretion.
Academic Article	Crohn''s and Parkinson''s Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo.
Academic Article	Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses.
Academic Article	Proteomic and biological profiling of extracellular vesicles from Alzheimer''s disease human brain tissues.
Academic Article	P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice.
Academic Article	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer''s Disease Patients: A Pilot Study.
Grant	Biogenesis of Exosomes, Secretion, and Trafficking in Alzheimer's Disease
Grant	Evaluation of the effect of cell type-specific deletion of ESCRT genes on the spread of tau pathology
Grant	Alzheimer Disease Genetic Architecture in African Americans
Grant	Evaluation of STX6 silencing on the novel AAV-based PSP model
Grant	Exosome-mediated Dissemination of Tau Aggregation in Alzheimer's Disease
Grant	Therapeutic evaluation of novel tau kinase inhibitors in Alzheimer's disease
Grant	Development of cell-based shRNA screening platform for targeting exosome pathway
Grant	Alzheimer Disease Genetic Architecture in African Americans
Grant	Validating TTBK1 as a target for Alzheimer’s disease
Grant	Characterization of Microglial Signaling in Maternal Immune Activation-related Autism
Grant	Eisai-Boston University Innovative Medicines for Alzheimer Disease and Dementia (EBiAD)
Grant	Characterization of Microglial Signaling in Maternal Immune Activation-related Autism
Grant	Target validation and development of drug discovery platform for TREM2/TYROBP signaling pathway modular
Grant	Microglia and exosome-mediated tau spreading mechanism in Alzheimer's disease brain
Grant	Identification of exosome signature in serum from ALS patients
Grant	Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease
Grant	Targeting the miR-155 and APOE-TREM2 pathways to restore dysfunctional microglia in Alzheimer's disease
Grant	miRNA/STAT3 axis as a novel therapeutic target of Down Syndrome
Grant	LRRK2 in the Immune System Program
Grant	Characterization of Microglial Wnt Signaling in Maternal Immune Activation-Related Autism
Grant	Characterization of Microglial Wnt Signaling in Maternal Immune Activation-Related Autism
Academic Article	Alzheimer''s disease brain-derived extracellular vesicles spread tau pathology in interneurons.

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Alzheimer
s
disease