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first name Christopher
full name Christopher V. Gabel, PhD
label Gabel, Christopher
Research Expertise & Professional Interests Our research program is focused on the development and application of femtosecond laser surgery and optical neurophysiology to the study of the nervous system of the nematode worm C. elegans. Using tightly focused pulses from an ultrafast laser, we can ablate regions of biological tissue with submicron precision, making it possible to snip individual nerve fibers within an intact worm (Fig 1). This enables in vivo study of neural regeneration and dissection of neurocircuitry at a new level of resolution. A small transparent body, simple stereotyped nervous system and powerful genetic tools combined to make C. elegans an ideal model organism for this work. Femtosecond laser technology applied to this versatile and tractable system allows us to tackle fundamental questions in neural regeneration and function.
Self-Described Keywords C. elegans

One or more keywords matched the following items that are connected to Gabel, Christopher

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Concept Acetylcholine
Concept Actins
Concept Aging
Concept Pentanols
Concept Aluminum Oxide
Concept Bacterial Proteins
Concept Calcium
Concept Calcium-Binding Proteins
Concept Cell Communication
Concept Cell Membrane
Concept Cell Movement
Concept Cell Nucleus
Concept Cell Survival
Concept Cells, Cultured
Concept Cerebral Cortex
Concept Chick Embryo
Concept Cold Temperature
Concept Cornea
Concept Cytoplasm
Concept Disease Models, Animal
Concept Dose-Response Relationship, Drug
Concept Epithelial Cells
Concept Escherichia coli
Concept Flow Cytometry
Concept Fluorescent Dyes
Concept Food
Concept Immunoglobulins
Concept Insulin
Concept Ion Channels
Concept Isoflurane
Concept Luminescent Proteins
Concept Membrane Proteins
Concept Models, Neurological
Concept Molecular Sequence Data
Concept Nerve Degeneration
Concept Nerve Tissue Proteins
Concept Organ Culture Techniques
Concept Phylogeny
Concept Plasmids
Concept Polystyrenes
Concept Quality Control
Concept Receptors, Cholinergic
Concept Receptor, Insulin
Concept Sensory Receptor Cells
Concept Recombinant Fusion Proteins
Concept Retinal Ganglion Cells
Concept Rhodopsin
Concept Sensitivity and Specificity
Concept Sepharose
Concept Temperature
Concept Time Factors
Concept Titanium
Concept Transcription Factors
Concept Ytterbium
Concept Reproducibility of Results
Concept Caenorhabditis elegans
Concept Photosensitizing Agents
Concept Protein-Serine-Threonine Kinases
Concept N-Acetylglucosaminyltransferases
Concept Receptors, Neuropeptide Y
Concept Receptors, AMPA
Concept Microscopy, Confocal
Concept Anesthetics, Inhalation
Concept Molecular Chaperones
Concept Proton-Motive Force
Concept Cell Lineage
Concept Proto-Oncogene Proteins c-bcl-2
Concept Equipment Failure Analysis
Concept Neurodegenerative Diseases
Concept Ryanodine Receptor Calcium Release Channel
Concept Diacylglycerol Kinase
Concept Calcium Signaling
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Caspases
Concept Optic Nerve Injuries
Concept Molecular Motor Proteins
Concept Growth Cones
Concept rac GTP-Binding Proteins
Concept Calcium Channels, L-Type
Concept MAP Kinase Kinase Kinases
Concept Mitochondrial Proteins
Concept Principal Component Analysis
Concept Caenorhabditis elegans Proteins
Concept Escherichia coli Proteins
Concept Calreticulin
Concept Mechanotransduction, Cellular
Concept Proteasome Endopeptidase Complex
Concept Cell Size
Concept Green Fluorescent Proteins
Concept Armadillo Domain Proteins
Concept Caspase 3
Concept Cell-Derived Microparticles
Concept TOR Serine-Threonine Kinases
Concept In Vitro Techniques
Concept Protein Aggregates
Academic Article Parallel microchannel-based measurements of individual erythrocyte areas and volumes.
Academic Article The speed of the flagellar rotary motor of Escherichia coli varies linearly with protonmotive force.
Academic Article Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types.
Academic Article The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation.
Academic Article A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans.
Academic Article Short-term adaptation and temporal processing in the cryophilic response of Caenorhabditis elegans.
Academic Article Neural circuits mediate electrosensory behavior in Caenorhabditis elegans.
Academic Article Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans.
Academic Article Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradients.
Academic Article Mechanosensation and mechanical load modulate the locomotory gait of swimming C. elegans.
Academic Article Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans.
Academic Article Olfactory behavior of swimming C. elegans analyzed by measuring motile responses to temporal variations of odorants.
Academic Article Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans.
Academic Article Watching worms whither: modeling neurodegeneration in C. elegans.
Academic Article Laser microsurgery in Caenorhabditis elegans.
Academic Article The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans.
Academic Article In vivo neuronal calcium imaging in C. elegans.
Academic Article Femtosecond laser ablation reveals antagonistic sensory and neuroendocrine signaling that underlie C. elegans behavior and development.
Academic Article Long-term imaging of Caenorhabditis elegans using nanoparticle-mediated immobilization.
Academic Article Neuronal repair: Apoptotic proteins make good.
Academic Article Neuronal regeneration in C. elegans requires subcellular calcium release by ryanodine receptor channels and can be enhanced by optogenetic stimulation.
Academic Article Feeding state, insulin and NPR-1 modulate chemoreceptor gene expression via integration of sensory and circuit inputs.
Academic Article Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms.
Academic Article The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration.
Academic Article Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein.
Academic Article Novel DLK-independent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth.
Academic Article C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress.
Academic Article The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration.
Academic Article Breakdown of Neural Function under Isoflurane Anesthesia: In Vivo, Multineuronal Imaging in Caenorhabditis elegans.
Academic Article O-GlcNAc Signaling Orchestrates the Regenerative Response to Neuronal Injury in Caenorhabditis elegans.
Academic Article Sustained Ca2+ mobilizations: A quantitative approach to predict their importance in cell-cell communication and wound healing.
Academic Article CED-4 CARD domain residues can modulate non-apoptotic neuronal regeneration functions independently from apoptosis.
Academic Article Wedge prism approach for simultaneous multichannel microscopy.
Academic Article Ytterbium-doped fibre femtosecond laser offers robust operation with deep and precise microsurgery of C. elegans neurons.
Academic Article LED array reflectance microscopy for scattering-based multi-contrast imaging.
Academic Article Collapse of Global Neuronal States in Caenorhabditis elegans under Isoflurane Anesthesia.
Academic Article Isoflurane Exposure in Juvenile Caenorhabditis elegans Causes Persistent Changes in Neuron Dynamics.
Grant C. elegans model for mammalian lesion-conditioned axon regeneration
Grant Modulation of Cellular Metabolism to Maximize Neuronal Regeneration
Grant Wedge-based approach for simultaneous multi-channel microscopy
Grant Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage
Grant Molecular Determination of in vivo Cellular Calcium Signaling During Nerve Damage and Regeneration

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