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Search Results to David H. Farb, PhD

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Research Expertise & Professional Interests David H. Farb was appointed Professor and Chairman of the Department of Pharmacology & Experimental Therapeutics at Boston University School of Medicine in 1990. Dr. Farb is also Director of the university-wide NIGMS training program in Biomolecular Pharmacology. He has also served as a member of the Drug Development Work Group of Mass Insight, co-author of the Massachusetts Technology Road Map for Drug Discovery, and a consultant for a number of small to large pharmaceutical, biotechnology, and patent litigation companies. He is regularly interviewed by local, national and international media. As head of the Laboratory of Molecular Neurobiology, he focuses on the identification of pharmacological treatments for mental disorders of learning and memory. His research integrates existing electrophysiological, behavioral, pharmacological, and molecular genetic technologies in a novel systems-level platform for assessing the impact of cognitive enhancers such as neuroactive steroids upon fundamental hippocampal systems for pattern separation (encoding), and pattern completion (retrieval) that are believed to be essential for cognition in all mammals, including man. Deficits in aspects of episodic memory dependent on hippocampal function are evident in a variety of mental disorders, including schizophrenia, autism, Alzheimer’s Disease, and normal aging. Existing pharmacotherapies are limited and carry substantial risk of adverse effects. In search of new approaches for discovery, high-density electrophysiological recordings in awake behaving rats are being used to identify deficits in hippocampal function that underlie cognitive deficits exhibited by aged animals and animals reared in social isolation, the latter being a model for environmental stress during development. Drug delivery via nanoparticles encapsulating hydrophilic or hydrophobic molecules are being engineered for delivery across the blood brain barrier. Nanoparticle composition is being tailored to better deliver drug to specific target sites. Neuroactive drugs and proteins, biomarkers for novel diagnostics, sensitive dyes for neural mapping, and many other applications are envisioned. The major advantage of this technique is the noninvasive delivery of molecules to the CNS via a peripheral injection. A multidisciplinary approach that includes the techniques of neurophysiology, molecular biology, patch-clamp electrophysiology, cell biology, and molecular neuroanatomy are combined to elucidate the mechanisms and modalities of cognitive enhancers and the discovery of therapeutic treatments for disorders or diseases of the nervous system.

One or more keywords matched the following items that are connected to Farb, David

Item TypeName
Concept Motor Neurons
Concept Neurons
Concept Culture Techniques
Concept CA1 Region, Hippocampal
Concept CA3 Region, Hippocampal
Academic Article The inactivation of gamma-aminobutyric acid transaminase in dissociated neuronal cultures from spinal cord.
Academic Article GABA-mediated synaptic potentials in chick spinal cord and sensory neurons.
Academic Article 3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons.
Academic Article gamma-Aminobutyric acidA receptor regulation in culture: altered allosteric interactions following prolonged exposure to benzodiazepines, barbiturates, and methylxanthines.
Academic Article Phosphorylation factors control neurotransmitter and neuromodulator actions at the gamma-aminobutyric acid type A receptor.
Academic Article Dual activation of GABAA and glycine receptors by beta-alanine: inverse modulation by progesterone and 5 alpha-pregnan-3 alpha-ol-20-one.
Academic Article gamma-Aminobutyric acid (GABA) induces a receptor-mediated reduction in GABAA receptor alpha subunit messenger RNAs in embryonic chick neurons in culture.
Academic Article gamma-aminobutyric acidA receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture.
Academic Article 17beta-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors.
Academic Article Neuroprotective activity of a new class of steroidal inhibitors of the N-methyl-D-aspartate receptor.
Academic Article Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.
Academic Article Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons.
Academic Article Uptake and release of [3H]gamma-aminobutyric acid by embryonic spinal cord neurons in dissociated cell culture.
Academic Article Turnover and down-regulation of GABA(A) receptor alpha1, beta2S, and gamma1 subunit mRNAs by neurons in culture.
Academic Article A minimal promoter for the GABA(A) receptor alpha6-subunit gene controls tissue specificity.
Academic Article Distinct signal transduction pathways for GABA-induced GABA(A) receptor down-regulation and uncoupling in neuronal culture: a role for voltage-gated calcium channels.
Academic Article An initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit gene.
Academic Article Differential expression of gamma-aminobutyric acid type B receptor subunit mRNAs in the developing nervous system and receptor coupling to adenylyl cyclase in embryonic neurons.
Academic Article cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters.
Academic Article GABA induces activity dependent delayed-onset uncoupling of GABA/benzodiazepine site interactions in neocortical neurons.
Academic Article Benzodiazepine modulation of partial agonist efficacy and spontaneously active GABA(A) receptors supports an allosteric model of modulation.
Academic Article Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor.
Academic Article Inverse modulation of gamma-aminobutyric acid- and glycine-induced currents by progesterone.
Academic Article Chlordiazepoxide selectively augments GABA action in spinal cord cell cultures.
Academic Article Transmembrane topology of the gamma-aminobutyric acidA/benzodiazepine receptor: subcellular distribution and allosteric coupling determined in situ.
Academic Article Identification of an intracellular pool of gamma-aminobutyric acidA/benzodiazepine receptors en route to the cell surface of brain neurons in culture.
Academic Article Modulation of neurotransmitter receptor desensitization: chlordiazepoxide stimulates fading of the GABA response.
Academic Article Mechanism of gamma-aminobutyric acid/benzodiazepine receptor turnover in neuronal cells: evidence for nonlysosomal degradation.
Academic Article "Run-down" of gamma-aminobutyric acidA receptor function during whole-cell recording: a possible role for phosphorylation.
Academic Article Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons.
Academic Article Benzodiazepine receptor photoaffinity labeling: correlation of function with binding.
Academic Article Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons.
Academic Article The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism.
Academic Article Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity.
Academic Article Benzodiazepine receptor synthesis and degradation by neurons in culture.
Academic Article Modulation of neuronal function through benzodiazepine receptors: biochemical and electrophysiological studies of neurons in primary monolayer cell culture.
Academic Article Chlordiazepoxide selectively potentiates GABA conductance of spinal cord and sensory neurons in cell culture.
Academic Article Multiple embryonic benzodiazepine binding sites: evidence for functionality.
Academic Article Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons.
Academic Article Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus.
Academic Article GABA-induced uncoupling of GABA/benzodiazepine site interactions is associated with increased phosphorylation of the GABAA receptor.
Academic Article First Colloquium in Biological Sciences. Ann. N.Y. Academy of Science
Academic Article Ann. N.Y. Academy of Science
Grant Mapping the Transcriptome of Age-Related Hippocampal Trisynaptic Circuit Dysfunction in a Rat Model for Alzheimer's Disease

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  • hippocampal
  • neurons
  • culture