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Search Results to Elizabeth S. Klings, MD

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One or more keywords matched the following properties of Klings, Elizabeth

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Research Expertise & Professional Interests Dr. Klings is an Associate Professor in the Department of Medicine. She is the Director of the Center for Excellence in Sickle Cell Disease and the Director of the Pulmonary Hypertension at BUSM/Boston Medical Center. She has an outpatient clinical practice focused on patients with pulmonary hypertension and those with pulmonary complications of sickle cell disease. She attends in the Medical Intensive Care Unit and on the Pulmonary Hypertension Consultation Service at Boston Medical Center. As Director of the largest sickle cell center in New England, Dr. Klings has created numerous new clinical programs for our patients and has expanded the clinical trials program. Dr. Klings’ research since fellowship has focused on pathogenesis of pulmonary vascular complications of sickle cell disease. She is an NIH-funded Principal Investigator .in the Pulmonary Center collaborating with numerous other investigators across the medical campus. She has phenotypically screened over 200 sickle cell patients at Boston Medical Center for the presence of pulmonary hypertension and currently investigating the roles of disease modulators including sleep-disordered breathing and venous thromboembolism in the endothelial and vascular dysfunction these patients experience. Known internationally as a leader in the care and treatment of patients with sickle cell disease, she was first author of the American Thoracic Society sponsored clinical guidelines for Diagnosis and Treatment of Pulmonary Hypertension in Sickle Cell Disease. She recently chaired an ATS sponsored workshop to define clinical and research priorities in sickle cell lung disease and serves on the NHLBI Sickle Cell Disease Advisory Committee.
Self-Described Keywords anemia, sickle cell

One or more keywords matched the following items that are connected to Klings, Elizabeth

Item TypeName
Concept Anemia, Sickle Cell
Concept Hemoglobin SC Disease
Academic Article Endothelial cell nitric oxide production in acute chest syndrome.
Academic Article Increased F2 isoprostanes in the acute chest syndrome of sickle cell disease as a marker of oxidative stress.
Academic Article Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease.
Academic Article Pulmonary hypertension as a risk factor for death in patients with sickle cell disease.
Academic Article Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70.
Academic Article Differential gene expression in pulmonary artery endothelial cells exposed to sickle cell plasma.
Academic Article Abnormal pulmonary function in adults with sickle cell anemia.
Academic Article Pulmonary hypertension of sickle cell disease: more than just another lung disease.
Academic Article Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: clinical characteristics and association with soluble adhesion molecule expression.
Academic Article Identification of oxidative post-translational modification of serum albumin in patients with idiopathic pulmonary arterial hypertension and pulmonary hypertension of sickle cell anemia.
Academic Article Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease.
Academic Article Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.
Academic Article Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study.
Academic Article Severe sickle cell anemia is associated with increased plasma levels of TNF-R1 and VCAM-1.
Academic Article Sickle cell anemia and vascular dysfunction: the nitric oxide connection.
Academic Article Ancestry of African Americans with sickle cell disease.
Academic Article Keeping it in the family: three relatives with HbSC disease and simultaneous acute pulmonary emboli.
Academic Article A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.
Academic Article Monocytes from sickle cell disease patients induce differential pulmonary endothelial gene expression via activation of NF-?B signaling pathway.
Academic Article Making it personal: using genomics to predict pulmonary hypertension in sickle cell disease.
Academic Article An official American Thoracic Society clinical practice guideline: diagnosis, risk stratification, and management of pulmonary hypertension of sickle cell disease.
Academic Article Management of patients with sickle cell disease.
Academic Article Pulmonary hypertension of sickle cell disease beyond classification constraints.
Academic Article Pulmonary hypertension in sickle cell disease.
Academic Article Reply: Practice guideline for pulmonary hypertension in sickle cell: direct evidence needed before universal adoption.
Academic Article Pulmonary hypertension in sickle cell disease: diagnosis and management.
Academic Article Chronic Pulmonary Complications of Sickle Cell Disease.
Academic Article Sleep-disordered breathing and nocturnal hypoxemia in young adults with sickle cell disease.
Academic Article Sickle cell disease: wheeze or asthma?
Academic Article Prostacyclin-analog therapy in sickle cell pulmonary hypertension.
Academic Article Clinical and laboratory findings associated with sleep disordered breathing in sickle cell disease.
Academic Article Standard measures for sickle cell disease research: the PhenX Toolkit sickle cell disease collections.
Academic Article Commentary: Heterogeneity of respiratory disease in children and young adults with sickle cell disease.
Academic Article A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells.
Academic Article Bronchodilator Use for Acute Chest Syndrome Among Large Pediatric Hospitals in North America.
Academic Article Epidemiology and Perioperative Complications in Patients With Sickle Cell Disease After Orthopaedic Surgery: 26 Years'' Experience at a Major Academic Center.
Academic Article Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report.
Academic Article Reply: Ethnically Diverse Normative Data for Diffusing Capacity and Lung Volumes.
Academic Article End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings.
Academic Article The effect of anticoagulant choice on venous thromboembolism recurrence and bleeding in sickle cell disease.
Grant Neutrophil Elastase as a Biomarker for Neutrophil-mediated Pathbiology in Sickle Cell Disease
Grant Hematopoietic Stem Cell Transplantation for Young Adults with Sickle Cell Disease
Grant Protocol # INCB59872-102, A Phase 1 Open-Label, Dose-Escalation/Dose-Expansion Safety and Tolerability Study of INCB059872 in Subjects with Sickle Cell Disease
Grant Protein biomarkers of pulmonary hypertension in sickle cell disease
Grant Protocol # STERIO-SCD, A Phase lib Randomized, Double-Blind, Placebo-Controlled Multi-Center Study to Assess the Safety, Tolerability, and Efficacy of Riociguat in Patients with Sickle Cell Diseases
Grant The Safety and Efficacy of Macitentan for Treatment of Pulmonary Hypertension in Sickle Cell Disease

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  • sickle cell disease