Search Results to Josee Dupuis, PhD

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Research Expertise & Professional Interests Josée Dupuis, Ph.D, is a Professor and Chair of Biostatistics at Boston University School of Public Health. She previously held a faculty position at Northwestern University and a senior statistical geneticist position at Genome Therapeutics Corporation, a small biotech company. She has extensive experience in the development and application of methods for genome-wide association studies, gene by environment interaction investigation, genetic meta-analysis and rare variant analysis, with special emphasis on the development of novel statistical approaches to analyze genetic data collected on large families. She is involved in the Framingham Heart Study, collaborating on projects to identify genes influencing diabetes related traits, pulmonary function traits and atrial fibrillation. She teaches BS860 (Statistical Genetics II) in the spring semester of even years.
Self-Described Keywords Gene-Environment Interactions

One or more keywords matched the following items that are connected to Dupuis, Josee

Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Base Sequence
Concept Environment
Concept Epistasis, Genetic
Concept Gene Expression Regulation
Concept Gene Frequency
Concept Genes
Concept Genes, Dominant
Concept Gene Expression
Concept Genome, Human
Concept Gene Expression Regulation, Enzymologic
Concept Sequence Homology, Amino Acid
Concept Gene Dosage
Concept Polymorphism, Single Nucleotide
Concept Gene Expression Profiling
Concept Quantitative Trait Loci
Concept Regulatory Elements, Transcriptional
Concept Gene Regulatory Networks
Concept Genetic Loci
Concept Genetic Pleiotropy
Concept Nucleotide Motifs
Concept Transcriptome
Concept Exome
Concept Gene-Environment Interaction
Academic Article Phenocopies for deafness and goiter development in a large inbred Brazilian kindred with Pendred's syndrome associated with a novel mutation in the PDS gene.
Academic Article Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds.
Academic Article A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.
Academic Article Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.
Academic Article Exo-proofreading, a versatile SNP scoring technology.
Academic Article The insulin gene variable number tandem repeat and risk of type 2 diabetes in a population-based sample of families and unrelated men and women.
Academic Article Expectation maximization algorithm based haplotype relative risk (EM-HRR): test of linkage disequilibrium using incomplete case-parents trios.
Academic Article Peptidoglycan recognition proteins Pglyrp3 and Pglyrp4 are encoded from the epidermal differentiation complex and are candidate genes for the Psors4 locus on chromosome 1q21.
Academic Article Comparisons of case-selection approaches based on allele sharing and/or disease severity index: application to the GAW14 simulated data.
Academic Article PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample.
Academic Article The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study.
Academic Article Polymorphisms in the endothelial nitric oxide synthase gene and bone density/ultrasound and geometry in humans.
Academic Article Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.
Academic Article Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.
Academic Article Common variants at 30 loci contribute to polygenic dyslipidemia.
Academic Article Variants in the CNR1 and the FAAH genes and adiposity traits in the community.
Academic Article Mapping quantitative traits in unselected families: algorithms and examples.
Academic Article Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci.
Academic Article Genotype score in addition to common risk factors for prediction of type 2 diabetes.
Academic Article Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies.
Academic Article Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.
Academic Article Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
Academic Article New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Academic Article The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations.
Academic Article Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients.
Academic Article Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Academic Article Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
Academic Article Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.
Academic Article Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease.
Academic Article Genetic associations with metabolic syndrome and its quantitative traits by race/ethnicity in the United States.
Academic Article A genome-wide association search for type 2 diabetes genes in African Americans.
Academic Article Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
Academic Article Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III).
Academic Article Impact of common variation in bone-related genes on type 2 diabetes and related traits.
Academic Article A comparison of gene region simulation methods.
Academic Article No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.
Academic Article Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
Academic Article Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
Academic Article Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource.
Academic Article Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.
Academic Article Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts.
Academic Article Network-guided sparse regression modeling for detection of gene-by-gene interactions.
Academic Article Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study.
Academic Article Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
Academic Article Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
Academic Article Correction for multiple testing in a gene region.
Academic Article Large multiethnic Candidate Gene Study for C-reactive protein levels: identification of a novel association at CD36 in African Americans.
Academic Article Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function.
Academic Article Whole blood gene expression and interleukin-6 levels.
Academic Article Association of levels of fasting glucose and insulin with rare variants at the chromosome 11p11.2-MADD locus: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Academic Article Pleiotropic genes for metabolic syndrome and inflammation.
Academic Article Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
Academic Article Modeling gene-covariate interactions in sparse regression with group structure for genome-wide association studies.
Academic Article Whole blood gene expression and atrial fibrillation: the Framingham Heart Study.
Academic Article Association of exome sequences with plasma C-reactive protein levels in >9000 participants.
Academic Article Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults.
Academic Article Incorporating gene-environment interaction in testing for association with rare genetic variants.
Academic Article Gene expression markers of age-related inflammation in two human cohorts.
Academic Article Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
Academic Article Revisiting heritability accounting for shared environmental effects and maternal inheritance.
Academic Article Evaluation of a Two-Stage Approach in Trans-Ethnic Meta-Analysis in Genome-Wide Association Studies.
Academic Article Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.
Academic Article Genome-wide gene-environment interactions on quantitative traits using family data.
Academic Article Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Academic Article Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.
Academic Article Joint association analysis of a binary and a quantitative trait in family samples.
Academic Article Association of the IGF1 gene with fasting insulin levels.
Academic Article Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.
Academic Article Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels.
Academic Article Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke.
Academic Article DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.
Academic Article A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Academic Article Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.
Academic Article An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
Academic Article Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer''s disease.
Academic Article MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage.
Academic Article Heritability of Atrial Fibrillation.
Academic Article Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.
Academic Article Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.
Academic Article Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations.
Academic Article Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer''s Disease Sequencing Project.
Academic Article Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
Academic Article ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls.
Academic Article Comparison of methods for multivariate gene-based association tests for complex diseases using common variants.
Academic Article Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Academic Article An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.
Academic Article Integrative Omics Approach to Identifying Genes Associated With Atrial Fibrillation.
Academic Article A unified method for rare variant analysis of gene-environment interactions.
Academic Article Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts.
Academic Article Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease.
Grant Multi-Cohort, Network-Guided Regression for GE/GG Interactions in Disease Traits
Grant Multiethnic Study of Type 2 Diabetes Genes

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  • Gene
  • Environment
  • Interactions