Search Results to Lawreen Heller Connors, PhD

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Research Expertise & Professional Interests Dr. Connors received dual undergraduate degrees in Chemistry and Mathematics from Boston College, a master’s degree in Chemistry from Tufts University, and doctoral degree in Biochemistry from Boston University. She joined the Amyloidosis Center as a post-doctoral trainee in 1994, and obtained faculty appointments in the Departments of Biochemistry and Pathology & Laboratory Medicine in 1998 and 2009, respectively. Dr. Connors focuses her basic science research on uncovering the protein and genetic determinants that underlie the formation of amyloid. The early stages of her career featured structural analyses of amyloid-causing transthyretin (TTR) mutants, mainly those causing cardiac dysfunction. More recently, her studies have been focused on wild-type TTR amyloidosis, an age-related disease now recognized as an under-appreciated cause of heart failure in the elderly. She has received continuous support from the NIH and foundation grants, as well as industry-sponsored research agreements, and has authored more than 100 peer-reviewed scholarly articles and book chapters. In 2009, Dr. Connors played a major role in establishment of the Amyloid Pathology Diagnostic Testing Laboratory in the Amyloidosis Center, a CAP-accredited and CLIA-certified facility that offers histologic and molecular testing for amyloid. Dr. Connors teaches GMS classes on systemic amyloidosis, and has mentored more than 20 master’s, doctoral and postdoctoral students. She has served on multiple local, national and international committees, and is Director of the Amyloidosis Center Gerry Laboratory and Co-Director of the Amyloid Pathology Diagnostic Testing Laboratory.

One or more keywords matched the following items that are connected to Connors, Lawreen

Item TypeName
Concept Amyloid
Concept Serum Amyloid A Protein
Concept Blood Protein Electrophoresis
Concept Blood Proteins
Concept C-Reactive Protein
Concept Disease Models, Animal
Concept Eye Diseases
Concept Kidney Diseases
Concept Liver Diseases
Concept Myeloma Proteins
Concept Peripheral Nervous System Diseases
Concept Protein Binding
Concept Protein Conformation
Concept Protein Denaturation
Concept Protein Precursors
Concept Protein Processing, Post-Translational
Concept Proteins
Concept Recombinant Proteins
Concept Retinol-Binding Proteins
Concept Submandibular Gland Diseases
Concept von Willebrand Diseases
Concept Amyloid beta-Protein Precursor
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Disease-Free Survival
Concept Proto-Oncogene Proteins c-bcl-2
Concept Protein Renaturation
Concept Protein Structure, Quaternary
Concept Amyloid Neuropathies, Familial
Concept Genetic Diseases, Inborn
Concept Protein Kinase Inhibitors
Concept p38 Mitogen-Activated Protein Kinases
Concept Mutant Proteins
Concept Retinol-Binding Proteins, Plasma
Concept Protein Stability
Concept Plaque, Amyloid
Concept Protein Unfolding
Concept Protein Aggregates
Academic Article A new transthyretin variant (Ser23Asn) associated with familial amyloidosis in a Portuguese patient.
Academic Article A new amyloidogenic transthyretin variant (Val122Ala) found in a compound heterozygous patient.
Academic Article Tabulation of transthyretin (TTR) variants as of 1/1/2000.
Academic Article Betabellins 15D and 16D, de Novo designed beta-sandwich proteins that have amyloidogenic properties.
Academic Article Biophysical analysis of normal transthyretin: implications for fibril formation in senile systemic amyloidosis.
Academic Article Identification of a novel transthyretin Thr59Lys/Arg104His. A case of compound heterozygosity in a Chinese patient diagnosed with familial transthyretin amyloidosis.
Academic Article Transthyretin amyloidosis associated with a novel variant (Trp41Leu) presenting with vitreous opacities.
Academic Article Identification of S-sulfonation and S-thiolation of a novel transthyretin Phe33Cys variant from a patient diagnosed with familial transthyretin amyloidosis.
Academic Article Tabulation of human transthyretin (TTR) variants, 2003.
Academic Article Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress.
Academic Article A rare transthyretin mutation (Asp18Glu) associated with cardiomyopathy.
Academic Article Cellular response of cardiac fibroblasts to amyloidogenic light chains.
Academic Article Thermodynamic stability of a kappaI immunoglobulin light chain: relevance to multiple myeloma.
Academic Article Quantitative serum free light chain assay in the diagnostic evaluation of AL amyloidosis.
Academic Article Association of acquired von Willebrand syndrome with AL amyloidosis.
Academic Article Expression, purification, and in vitro cysteine-10 modification of native sequence recombinant human transthyretin.
Academic Article Role of endocytic inhibitory drugs on internalization of amyloidogenic light chains by cardiac fibroblasts.
Academic Article Detailed structural analysis of amyloidogenic wild-type transthyretin using a novel purification strategy and mass spectrometry.
Academic Article A new transthyretin variant (Glu61Gly) associated with cardiomyopathy.
Academic Article Heterogeneity in primary structure, post-translational modifications, and germline gene usage of nine full-length amyloidogenic kappa1 immunoglobulin light chains.
Academic Article Soft tissue, joint, and bone manifestations of AL amyloidosis: clinical presentation, molecular features, and survival.
Academic Article The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation.
Academic Article Serum transthyretin levels in senile systemic amyloidosis: effects of age, gender and ethnicity.
Academic Article Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue.
Academic Article AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequences.
Academic Article Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition.
Academic Article Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway.
Academic Article Role of glycosaminoglycan sulfation in the formation of immunoglobulin light chain amyloid oligomers and fibrils.
Academic Article Spontaneous rupture of the liver in a patient with systemic AL amyloidosis undergoing treatment with high-dose melphalan and autologous stem cell transplantation: a case report with literature review.
Academic Article Isolation and characterization of a kappa amyloid fibril protein.
Academic Article The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain.
Academic Article Preclinical development of siRNA therapeutics for AL amyloidosis.
Academic Article Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis.
Academic Article Dysregulation of miRNAs in AL amyloidosis.
Academic Article Metabolic phenotype in an AL amyloidosis transgenic mouse model.
Academic Article High-dose melphalan and autologous stem cell transplantation for AL amyloidosis: recent trends in treatment-related mortality and 1-year survival at a single institution.
Academic Article Clinical features and survival in senile systemic amyloidosis: comparison to familial transthyretin cardiomyopathy.
Academic Article Detection of high-molecular-weight amyloid serum protein complexes using biological on-line tracer sedimentation.
Academic Article A new lysozyme tyr54asn mutation causing amyloidosis in a family of Swedish ancestry with gastrointestinal symptoms.
Academic Article Circulating matrix metalloproteinases and tissue inhibitors of metalloproteinases in cardiac amyloidosis.
Academic Article Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish.
Academic Article In vitro formation of amyloid fibrils from intact beta 2-microglobulin.
Academic Article The pathogenesis and biochemistry of amyloidosis.
Academic Article The association of an elastase with amyloid fibrils.
Academic Article Nephelometric measurement of human serum prealbumin and correlation with acute-phase proteins CRP and SAA: results in familial amyloid polyneuropathy.
Academic Article Selective binding of nifedipine to amyloid fibrils.
Academic Article Lowered prealbumin levels in patients with familial amyloid polyneuropathy (FAP) and their non-affected but at risk relatives.
Academic Article Observations on the amyloid-degrading activity of serum and its relationship to human neutrophil elastase.
Academic Article Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity.
Academic Article Homozygosity for the V122I mutation in transthyretin is associated with earlier onset of cardiac amyloidosis in the African American population in the seventh decade of life.
Academic Article Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils.
Academic Article Cooperative stabilization of transthyretin by clusterin and diflunisal.
Academic Article Vertebral compression fractures as the initial presentation of AL amyloidosis: case series and review of literature.
Academic Article Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt).
Academic Article Heart Failure Resulting From Age-Related Cardiac Amyloid Disease Associated With Wild-Type Transthyretin: A Prospective, Observational Cohort Study.
Academic Article Immunoglobulin heavy light chain test quantifies clonal disease in patients with AL amyloidosis and normal serum free light chain ratio.
Academic Article Retinol binding protein 4 (RBP4) concentration identifies V122I transthyretin cardiac amyloidosis.
Academic Article Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model.
Academic Article Blood Proteomic Profiling in Inherited (ATTRm) and Acquired (ATTRwt) Forms of Transthyretin-Associated Cardiac Amyloidosis.
Academic Article Familial wild-type transthyretin cardiomyopathy.
Grant The Effects of TTR-T119M on TTR Tetramer Stability and Amyloid Fibril Formation
Academic Article In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis.
Academic Article Serum Proteomic Variability Associated with Clinical Phenotype in Familial Transthyretin Amyloidosis (ATTRm).
Academic Article Prevalence of mutant ATTR cardiac amyloidosis in elderly African Americans with heart failure.
Academic Article Monoclonal gammopathy of undetermined significance in systemic transthyretin amyloidosis (ATTR).
Academic Article Use of Serum Transthyretin as a Prognostic Indicator and Predictor of Outcome in Cardiac Amyloid Disease Associated With Wild-Type Transthyretin.
Academic Article Oxidative Post-Translational Modifications of an Amyloidogenic Immunoglobulin Light Chain Protein.
Academic Article Features of atrial fibrillation in wild-type transthyretin cardiac amyloidosis: a systematic review and clinical experience.
Academic Article Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease.
Academic Article A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics.
Academic Article Use of Ventilatory Efficiency Slope as a Marker for Increased Mortality in Wild-Type Transthyretin Cardiac Amyloidosis.
Academic Article Predictors of Mortality in Light Chain Cardiac Amyloidosis with Heart Failure.
Academic Article Alterations in the secondary structure of mutant transthyretins associated with familial amyloidotic polyneuropathy after proteolysis by neutrophil serine elastases
Academic Article A new era of amyloidosis: the trends at a major US referral centre.
Academic Article Analysis of the non-coding rs3764479 mutation in the proximal promoter of the transthyretin gene.
Academic Article Structural studies of serum clusterin in ATTRwt amyloidosis.
Academic Article Effect of diflunisal on clusterin levels in ATTRwt amyloidosis.
Academic Article Structural Characterization of Cardiac Ex Vivo Transthyretin Amyloid: Insight into the Transthyretin Misfolding Pathway In Vivo.
Academic Article Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease.
Grant Renal Immunoglobulin Light Chain Amyloidosis: Translational studies probing disease mechanism as a platform for drug development.
Grant Immunohistochemical analyses of Proclara Fusion Protein, NPT189, in Amyloid-infiltrated human heart tissues
Grant Contribution of Immunoglobulin Constant Domain to Amyloid Formation, Part 4

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  • Protein
  • misfolding
  • amyloid
  • diseases