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Search Results to Gregory A. Viglianti, PhD

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Research Expertise & Professional Interests Research in my laboratory focuses on two main areas: 1) co-factors that influence the mucosal transmission of HIV-1; and 2) the role of endogenous nucleic acid autoantigens as mediators of systemic lupus erythematosus. 1) Mucosal immune responses of the lower female reproductive tract to sexually transmitted pathogenic microorganisms leads to an inflammatory response that enhances the heterosexual transmission of HIV-1. Inflammation is initiated largely by signaling through members of the Toll-like family of innate immune receptors (TLR) that are activated by pathogen-encoded ligands. This inflammatory response enhances HIV-1 transmission by inducing the recruitment of target immune cells such as Langerhans/dendritic cells (LC/DC), macrophages (MØ)‚ and T lymphocytes to the mucosa and by direct activation of these cells. Recent findings have demonstrated that activation of certain nuclear receptors (NR), including peroxisome proliferator activated receptor (PPAR), liver X receptor (LXR), and glucocorticoid receptor (GR)) potently inhibits TLR-induced inflammatory gene expression in MØ, LC/DC, and epithelial cells. Studies in our laboratory are directed toward evaluating: 1) the ability of ligand-activated NR to inhibit the mucosal transmission of HIV-1, in particular LC/DC-mediated trans-infection of T cells; and 2) the molecular mechanism(s) of how ligand-activated NR inhibit TLR-induced transcription of both HIV-1 and inflammatory cytokine genes. 2) Autoimmune diseases such as systemic lupus erythematosus (SLE) are characterized by the overproduction of antibodies, many of which recognize ribonucleoprotein and/or chromatin related autoantigens. A common feature of these autoantigens is that they include DNA or RNA. Our laboratory, in collaboration with Dr. Ann Marshak-Rothstein, is defining the protein and nucleic acid composition of these immunostimulatory autoantigens and determining whether different forms of apoptosis are capable of selectively releasing these autoantigens from cells, thereby making them accessible to autoreactive B cells.
Self-Described Keywords Retrovirology: chromatin structure/function: gene regulation: HIV: autoimmunity
Self-Described Keywords Retrovirology: nuclear receptors: macrophages: dendritic cells: mucosal transmission: gene regulation: HIV: autoimmunity: Toll like receptors

One or more keywords matched the following items that are connected to Viglianti, Gregory

Item TypeName
Concept Amino Acid Sequence
Concept Base Sequence
Concept Gene Expression Regulation
Concept Genes
Concept Genes, Viral
Concept Molecular Sequence Data
Concept Nucleic Acid Conformation
Concept Repetitive Sequences, Nucleic Acid
Concept Sequence Homology, Nucleic Acid
Concept Down-Regulation
Concept Gene Products, env
Concept Gene Products, tat
Concept Genes, env
Concept Up-Regulation
Concept Gene Expression
Concept Gene Expression Regulation, Viral
Concept Genes, fos
Concept tat Gene Products, Human Immunodeficiency Virus
Concept Gene Knockdown Techniques
Academic Article Synergistic activation of simian immunodeficiency virus and human immunodeficiency virus type 1 transcription by retinoic acid and phorbol ester through an NF-kappa B-independent mechanism.
Academic Article IL-16 represses HIV-1 promoter activity.
Academic Article A lipidated anti-Tat antibody enters living cells and blocks HIV-1 viral replication.
Academic Article IL-16 anti-HIV-1 therapy.
Academic Article Retinoid-induced repression of human immunodeficiency virus type 1 core promoter activity inhibits virus replication.
Academic Article Both PU.1 and nuclear factor-kappa B mediate lipopolysaccharide- induced HIV-1 long terminal repeat transcription in macrophages.
Academic Article Feline leukemia virus subgroup C phenotype evolves through distinct alterations near the N terminus of the envelope surface glycoprotein.
Academic Article Role of TAR RNA splicing in translational regulation of simian immunodeficiency virus from rhesus macaques.
Academic Article Retinoid-dependent restriction of human immunodeficiency virus type 1 replication in monocytes/macrophages.
Academic Article Simian immunodeficiency virus displays complex patterns of RNA splicing.
Academic Article Alteration of hsp82 gene expression by the gypsy transposon and suppressor genes in Drosophila melanogaster.
Academic Article PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection.
Academic Article Functional comparison of transactivation by simian immunodeficiency virus from rhesus macaques and human immunodeficiency virus type 1.
Academic Article Fc?RIIB regulation of BCR/TLR-dependent autoreactive B-cell responses.
Academic Article Nuclear receptor signaling inhibits HIV-1 replication in macrophages through multiple trans-repression mechanisms.
Academic Article Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.
Academic Article Blimp-1, an intrinsic factor that represses HIV-1 proviral transcription in memory CD4+ T cells.
Academic Article Porphyromonas gingivalis-mediated signaling through TLR4 mediates persistent HIV infection of primary macrophages.

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  • Gene
  • Regulation