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Search Results to Haiyan Gong, MD, PhD

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Research Expertise & Professional Interests Glaucoma is a leading cause of blindness worldwide. A primary risk factor for the development and progression of primary open-angle glaucoma (POAG) is elevation of intraocular pressure (IOP), which resulted from increased aqueous outflow resistance. However, the cause of this elevated aqueous outflow resistance in POAG remains unknown. The research in our laboratory is focused on understanding the mechanisms that regulate aqueous humor outflow resistance in normal eyes and how this resistance is increased in POAG in order to provide new insights for developing new therapeutic strategies to lower IOP.
Self-Described Keywords Aqueous outflow resistance

One or more keywords matched the following items that are connected to Gong, Haiyan

Item TypeName
Concept Aqueous Humor
Concept Blood-Aqueous Barrier
Academic Article Serum proteins and aqueous outflow resistance in bovine eyes.
Academic Article Hyaluronan in the bovine ocular anterior segment, with emphasis on the outflow pathways.
Academic Article Freeze-fracture studies of interendothelial junctions in the angle of the human eye.
Academic Article Morphology of the aqueous outflow pathway.
Academic Article The role of soluble proteins in generating aqueous outflow resistance in the bovine and human eye.
Academic Article Intraocular pressure and outflow facility are unchanged following acute and chronic intracameral chondroitinase ABC and hyaluronidase in monkeys.
Academic Article Interendothelial junctions in normal human Schlemm's canal respond to changes in pressure.
Academic Article Effects of Na-K-2Cl cotransport regulators on outflow facility in calf and human eyes in vitro.
Academic Article Co-localization of junction-associated proteins of the human blood--aqueous barrier: occludin, ZO-1 and F-actin.
Academic Article The mechanism of increasing outflow facility during washout in the bovine eye.
Academic Article Comparative studies between species that do and do not exhibit the washout effect.
Academic Article The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes.
Academic Article Reduction of the available area for aqueous humor outflow and increase in meshwork herniations into collector channels following acute IOP elevation in bovine eyes.
Academic Article The washout phenomenon in aqueous outflow--why does it matter?
Academic Article Morphological and hydrodynamic correlates in monkey eyes with laser induced glaucoma.
Academic Article Relationships between increased aqueous outflow facility during washout with the changes in hydrodynamic pattern and morphology in bovine aqueous outflow pathways.
Academic Article Development of a novel two color tracer perfusion technique for the hydrodynamic study of aqueous outflow in bovine eyes.
Academic Article Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes.
Academic Article 3D visualization of aqueous humor outflow structures in-situ in humans.
Academic Article Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures.
Academic Article Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow.
Academic Article Reversible changes in aqueous outflow facility, hydrodynamics, and morphology following acute intraocular pressure variation in bovine eyes.
Academic Article Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes.
Academic Article Pilocarpine-induced flare is physiological rather than pathological.
Academic Article Functional Anatomy of the Outflow Facilities.
Academic Article Endothelial glycocalyx layer in the aqueous outflow pathway of bovine and human eyes.
Academic Article Morphological and hydrodynamic correlations with increasing outflow facility by rho-kinase inhibitor Y-27632.
Academic Article Finite element analysis of the pressure-induced deformation of Schlemm''s canal endothelial cells.
Academic Article Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms.
Academic Article Duane’s Clinical Ophthalmology
Academic Article Principles and Practice of Ophthalmology
Academic Article Duane’s Clinical Ophthalmology
Academic Article Variations in active outflow along the trabecular outflow pathway.
Grant Outflow Area and its Role in Glaucoma Pathogenesis
Grant Evaluation of the Effect of an Alcon Drug on Aqueous Flow Pattern and Morphology in the Outflow Pathway using a Serum Amyloid A induced Ocular Hypertensive Mouse Model
Grant Hydrodynamics of Aqueous Humor Outflow
Grant Does Hydrodynamic Coupling Between the JCT and Inner Wall of Schlemm’s Canal Contribute to Outflow Resistance?
Academic Article Glaucoma Research and Clinical Advances 2016-2018, Knepper P, Samples J, editors
Academic Article Increased stiffness and flow resistance of the inner wall of Schlemm''s canal in glaucomatous human eyes.
Grant Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
Grant Function of Glycocalyx in the Trabecular Outflow Pathway
Grant Evaluation of the effect of an Aerie drug (AR-13324) on aqueous flow pattern and morphology in enucleated human eyes
Grant Cellular Physiology of the Aqueous Outflow Pathway
Grant CC Ostia Herniations and Outflow Resistance in POAG Eyes
Grant Effect of Netarsudil and AR-12286 on Effective Filtration Area and Morphology of the Trabecular Outflow Pathway
Grant Cellular Physiology of the Aqueous Outflow Pathway
Grant Cellular Physiology of the Aqueous Outflow Pathway
Grant Testing Effect of Sustained Release vs. Cyclic Exposure of Bimatoprost on MMP/TIMP/ECM Expression by Outflow Cells
Grant Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
Grant Evaluation of the Effect of An Alcon Drug on Aqueous Flow Pattern and morphology in the Outflow paathway
Grant Lysosomal Enzymes in Outflow Pathway Physiology and Pathophysiology
Academic Article Current Developments in Glaucoma Surgery and MIGS

Highlights
Search Criteria
  • Aqueous
  • outflow
  • resistance